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1000 Titel
  • Decreased inflammatory cytokine production of antigen-specific CD4+ T cells in NMDA receptor encephalitis
1000 Autor/in
  1. Dao, Le-Minh |
  2. Machule, Marie-Luise |
  3. Bacher, Petra |
  4. Hoffmann, Julius |
  5. Ly, Lam-Thanh |
  6. Wegner, Florian |
  7. Scheffold, Alexander |
  8. Prüss, Harald |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-01-13
1000 Erschienen in
1000 Quellenangabe
  • 268(6):2123-2131
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00415-020-10371-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179900/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis is the most common autoimmune encephalitis with psychosis, amnesia, seizures and dyskinesias. The disease is mediated by pathogenic autoantibodies against the NR1 subunit that disrupt NMDAR function. Antibody infusion into mouse brains can recapitulate encephalitis symptoms, while active immunization resulted also in strong T cell infiltration into the hippocampus. However, whether T cells react against NMDAR and their specific contribution to disease development are poorly understood. Here we characterized the ex vivo frequency and phenotype of circulating CD4
1000 Sacherschließung
lokal Anti-N-Methyl-D-Aspartate Receptor Encephalitis [MeSH]
lokal Antigen-reactive T cell enrichment
lokal LGI1
lokal Receptors, N-Methyl-D-Aspartate [MeSH]
lokal Humans [MeSH]
lokal CD4-Positive T-Lymphocytes [MeSH]
lokal Cytokines [MeSH]
lokal Encephalitis [MeSH]
lokal Animals [MeSH]
lokal Cytokines
lokal NMDAR encephalitis
lokal Mice [MeSH]
lokal Autoantibodies [MeSH]
lokal T-Lymphocytes [MeSH]
lokal Autoantibodies
lokal Original Communication
lokal T cells
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/RGFvLCBMZS1NaW5o|https://frl.publisso.de/adhoc/uri/TWFjaHVsZSwgTWFyaWUtTHVpc2U=|https://frl.publisso.de/adhoc/uri/QmFjaGVyLCBQZXRyYQ==|https://frl.publisso.de/adhoc/uri/SG9mZm1hbm4sIEp1bGl1cw==|https://frl.publisso.de/adhoc/uri/THksIExhbS1UaGFuaA==|https://frl.publisso.de/adhoc/uri/V2VnbmVyLCBGbG9yaWFu|https://frl.publisso.de/adhoc/uri/U2NoZWZmb2xkLCBBbGV4YW5kZXI=|https://orcid.org/0000-0002-8283-7976
1000 Hinweis
  • DeepGreen-ID: 370db62bca534e9b8de40aa1d7758552 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 @id frl:6450304.rdf
1000 Erstellt am 2023-05-09T11:54:27.715+0200
1000 Erstellt von 322
1000 beschreibt frl:6450304
1000 Zuletzt bearbeitet Sat Oct 21 03:06:21 CEST 2023
1000 Objekt bearb. Sat Oct 21 03:06:21 CEST 2023
1000 Vgl. frl:6450304
1000 Oai Id
  1. oai:frl.publisso.de:frl:6450304 |
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