Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas

  1. Kirches, Elmar
  2. Sahm, Felix
  3. Korshunov, Andrey
  4. Bluecher, Christina
  5. Waldt, Natalie
  6. Kropf, Siegfried
  7. Schrimpf, Daniel
  8. Sievers, Philipp
  9. Stichel, Damian
  10. Schüller, Ulrich
  11. Schittenhelm, Jens
  12. Riemenschneider, Markus J.
  13. Karajannis, Matthias A.
  14. Perry, Arie
  15. Pietsch, Torsten
  16. Boekhoff, Svenja
  17. Capper, David
  18. Beck, Katja
  19. Paramasivam, Nagarajan
  20. Schlesner, Matthias
  21. Brastianos, Priscilla K.
  22. Müller, Hermann L.
  23. Pfister, Stefan M.
  24. Mawrin, Christian ORCID logo

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1000 Titel
  • Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas
1000 Autor/in
  1. Kirches, Elmar |
  2. Sahm, Felix |
  3. Korshunov, Andrey |
  4. Bluecher, Christina |
  5. Waldt, Natalie |
  6. Kropf, Siegfried |
  7. Schrimpf, Daniel |
  8. Sievers, Philipp |
  9. Stichel, Damian |
  10. Schüller, Ulrich |
  11. Schittenhelm, Jens |
  12. Riemenschneider, Markus J. |
  13. Karajannis, Matthias A. |
  14. Perry, Arie |
  15. Pietsch, Torsten |
  16. Boekhoff, Svenja |
  17. Capper, David |
  18. Beck, Katja |
  19. Paramasivam, Nagarajan |
  20. Schlesner, Matthias |
  21. Brastianos, Priscilla K. |
  22. Müller, Hermann L. |
  23. Pfister, Stefan M. |
  24. Mawrin, Christian |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-09-08
1000 Erschienen in
1000 Quellenangabe
  • 142(5):873-886
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00401-021-02351-x |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500891/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • In contrast to adults, meningiomas are uncommon tumors in childhood and adolescence. Whether adult and pediatric meningiomas differ on a molecular level is unclear. Here we report detailed genomic analyses of 37 pediatric meningiomas by sequencing and DNA methylation profiling. Histologically, the series was dominated by meningioma subtypes with aggressive behavior, with 70% of patients suffering from WHO grade II or III meningiomas. The most frequent cytogenetic aberrations were loss of chromosomes 22 (23/37 [62%]), 1 (9/37 [24%]), 18 (7/37 [19%]), and 14 (5/37 [14%]). Tumors with NF2 alterations exhibited overall increased chromosomal instability. Unsupervised clustering of DNA methylation profiles revealed separation into three groups: designated group 1 composed of clear cell and papillary meningiomas, whereas group 2A comprised predominantly atypical meningiomas and group 2B enriched for rare high-grade subtypes (rhabdoid, chordoid). Meningiomas from NF2 patients clustered exclusively within groups 1 and 2A. When compared with a dataset of 105 adult meningiomas, the pediatric meningiomas largely grouped separately. Targeted panel DNA sequencing of 34 tumors revealed frequent NF2 alterations, while other typical alterations found in adult non-NF2 tumors were absent. These data demonstrate that pediatric meningiomas are characterized by molecular features distinct from adult tumors.
1000 Sacherschließung
lokal Meningeal Neoplasms/pathology [MeSH]
lokal Adolescent [MeSH]
lokal Female [MeSH]
lokal Targeted sequencing
lokal NF2
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Meningioma/genetics [MeSH]
lokal Male [MeSH]
lokal Meningeal Neoplasms/genetics [MeSH]
lokal Meningioma/pathology [MeSH]
lokal Original Paper
lokal Methylation profile
lokal Transcriptome [MeSH]
lokal Gene Expression Profiling [MeSH]
lokal Meningioma
lokal Child [MeSH]
lokal Child, Preschool [MeSH]
1000 Liste der Beteiligten
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1000 Erstellt am 2023-05-11T10:34:23.984+0200
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