Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice

  1. Gregorius, Jonas ORCID logo
  2. Wang, Chen
  3. Stambouli, Oumaima
  4. Hussner, Tanja
  5. Qi, Yachao
  6. Tertel, Tobias
  7. Börger, Verena
  8. Mohamud Yusuf, Ayan
  9. Hagemann, Nina
  10. Yin, Dongpei
  11. Dittrich, Robin
  12. Mouloud, Yanis
  13. Mairinger, Fabian D.
  14. Magraoui, Fouzi El
  15. Popa-Wagner, Aurel
  16. Kleinschnitz, Christoph
  17. Doeppner, Thorsten R.
  18. Gunzer, Matthias
  19. Meyer, Helmut E.
  20. Giebel, Bernd
  21. Hermann, Dirk M.

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1000 Titel
  • Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice
1000 Autor/in
  1. Gregorius, Jonas |
  2. Wang, Chen |
  3. Stambouli, Oumaima |
  4. Hussner, Tanja |
  5. Qi, Yachao |
  6. Tertel, Tobias |
  7. Börger, Verena |
  8. Mohamud Yusuf, Ayan |
  9. Hagemann, Nina |
  10. Yin, Dongpei |
  11. Dittrich, Robin |
  12. Mouloud, Yanis |
  13. Mairinger, Fabian D. |
  14. Magraoui, Fouzi El |
  15. Popa-Wagner, Aurel |
  16. Kleinschnitz, Christoph |
  17. Doeppner, Thorsten R. |
  18. Gunzer, Matthias |
  19. Meyer, Helmut E. |
  20. Giebel, Bernd |
  21. Hermann, Dirk M. |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-06-08
1000 Erschienen in
1000 Quellenangabe
  • 116(1):40
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00395-021-00881-9 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187185/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Obtained from the right cell-type, mesenchymal stromal cell (MSC)-derived small extracellular vesicles (sEVs) promote stroke recovery. Within this process, microvascular remodeling plays a central role. Herein, we evaluated the effects of MSC-sEVs on the proliferation, migration, and tube formation of human cerebral microvascular endothelial cells (hCMEC/D3) in vitro and on post-ischemic angiogenesis, brain remodeling and neurological recovery after middle cerebral artery occlusion (MCAO) in mice. In vitro, sEVs obtained from hypoxic (1% O
1000 Sacherschließung
lokal Neuronal survival
lokal Angiogenic Proteins/genetics [MeSH]
lokal Mice, Inbred C57BL [MeSH]
lokal Original Contribution
lokal Cell Movement [MeSH]
lokal Tube formation
lokal Angiogenic Proteins/metabolism [MeSH]
lokal Infarction, Middle Cerebral Artery/metabolism [MeSH]
lokal Male [MeSH]
lokal Extracellular Vesicles/metabolism [MeSH]
lokal Neovascularization, Physiologic [MeSH]
lokal MicroRNAs/genetics [MeSH]
lokal Polymorphonuclear neutrophil
lokal Disease Models, Animal [MeSH]
lokal Infarction, Middle Cerebral Artery/surgery [MeSH]
lokal Cell Hypoxia [MeSH]
lokal Endothelial Cells/metabolism [MeSH]
lokal Cell Proliferation [MeSH]
lokal Infarction, Middle Cerebral Artery/physiopathology [MeSH]
lokal Recovery of Function [MeSH]
lokal Humans [MeSH]
lokal Microvascular network characteristics
lokal MicroRNAs/metabolism [MeSH]
lokal Neurons/metabolism [MeSH]
lokal Extracellular Vesicles/transplantation [MeSH]
lokal Microvessels/physiopathology [MeSH]
lokal Animals [MeSH]
lokal Endothelial migration
lokal Time Factors [MeSH]
lokal Mesenchymal Stem Cells/metabolism [MeSH]
lokal Microvessels/metabolism [MeSH]
lokal Brain/blood supply [MeSH]
lokal Vascular Remodeling [MeSH]
lokal Neurons/pathology [MeSH]
lokal Signal Transduction [MeSH]
lokal Cells, Cultured [MeSH]
lokal Microvascular remodeling
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-6416-8289|https://frl.publisso.de/adhoc/uri/V2FuZywgQ2hlbg==|https://frl.publisso.de/adhoc/uri/U3RhbWJvdWxpLCBPdW1haW1h|https://frl.publisso.de/adhoc/uri/SHVzc25lciwgVGFuamE=|https://frl.publisso.de/adhoc/uri/UWksIFlhY2hhbw==|https://frl.publisso.de/adhoc/uri/VGVydGVsLCBUb2JpYXM=|https://frl.publisso.de/adhoc/uri/QsO2cmdlciwgVmVyZW5h|https://frl.publisso.de/adhoc/uri/TW9oYW11ZCBZdXN1ZiwgQXlhbg==|https://frl.publisso.de/adhoc/uri/SGFnZW1hbm4sIE5pbmE=|https://frl.publisso.de/adhoc/uri/WWluLCBEb25ncGVp|https://frl.publisso.de/adhoc/uri/RGl0dHJpY2gsIFJvYmlu|https://frl.publisso.de/adhoc/uri/TW91bG91ZCwgWWFuaXM=|https://frl.publisso.de/adhoc/uri/TWFpcmluZ2VyLCBGYWJpYW4gRC4=|https://frl.publisso.de/adhoc/uri/TWFncmFvdWksIEZvdXppwqBFbA==|https://frl.publisso.de/adhoc/uri/UG9wYS1XYWduZXIsIEF1cmVs|https://frl.publisso.de/adhoc/uri/S2xlaW5zY2huaXR6LCBDaHJpc3RvcGg=|https://frl.publisso.de/adhoc/uri/RG9lcHBuZXIsIFRob3JzdGVuIFIu|https://frl.publisso.de/adhoc/uri/R3VuemVyLCBNYXR0aGlhcw==|https://frl.publisso.de/adhoc/uri/TWV5ZXIsIEhlbG11dCBFLg==|https://frl.publisso.de/adhoc/uri/R2llYmVsLCBCZXJuZA==|https://frl.publisso.de/adhoc/uri/SGVybWFubiwgRGlyayBNLg==
1000 Hinweis
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1000 Erstellt am 2023-05-11T10:55:09.192+0200
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1000 Zuletzt bearbeitet Sat Oct 21 03:59:40 CEST 2023
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