Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection

  1. Goetzke, Carl Christoph
  2. Althof, Nadine
  3. Neumaier, Hannah Louise
  4. Heuser, Arndt
  5. Kaya, Ziya
  6. Kespohl, Meike
  7. Klingel, Karin
  8. Beling, Antje ORCID logo

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1000 Titel
  • Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection
1000 Autor/in
  1. Goetzke, Carl Christoph |
  2. Althof, Nadine |
  3. Neumaier, Hannah Louise |
  4. Heuser, Arndt |
  5. Kaya, Ziya |
  6. Kespohl, Meike |
  7. Klingel, Karin |
  8. Beling, Antje |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-02-01
1000 Erschienen in
1000 Quellenangabe
  • 116(1):7
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00395-021-00848-w |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851025/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • A preclinical model of troponin I-induced myocarditis (AM) revealed a prominent role of the immunoproteasome (ip), the main immune cell-resident proteasome isoform, in heart-directed autoimmunity. Viral infection of the heart is a known trigger of cardiac autoimmunity, with the ip enhancing systemic inflammatory responses after infection with a cardiotropic coxsackievirusB3 (CV). Here, we used ip-deficient A/J-LMP7
1000 Sacherschließung
lokal Myeloid Cells/enzymology [MeSH]
lokal Coxsackievirus Infections/enzymology [MeSH]
lokal Original Contribution
lokal Inflammation/enzymology [MeSH]
lokal Myeloid Cells/virology [MeSH]
lokal Oligopeptides/pharmacology [MeSH]
lokal Host-Pathogen Interactions [MeSH]
lokal Myocarditis/immunology [MeSH]
lokal Enterovirus B, Human/immunology [MeSH]
lokal Myocarditis
lokal Proteasome Inhibitors/pharmacology [MeSH]
lokal Myocytes, Cardiac/virology [MeSH]
lokal Myocytes, Cardiac/immunology [MeSH]
lokal Inflammation/virology [MeSH]
lokal Male [MeSH]
lokal Proteasome
lokal Inflammation/drug therapy [MeSH]
lokal Proteasome Endopeptidase Complex/metabolism [MeSH]
lokal Myocarditis/enzymology [MeSH]
lokal Myocytes, Cardiac/drug effects [MeSH]
lokal Coxsackievirus Infections/drug therapy [MeSH]
lokal Disease Models, Animal [MeSH]
lokal Myocarditis/drug therapy [MeSH]
lokal Inflammation/immunology [MeSH]
lokal Myocytes, Cardiac/enzymology [MeSH]
lokal Inflammation
lokal Myeloid Cells/immunology [MeSH]
lokal Animals [MeSH]
lokal Infection
lokal Mice, Knockout [MeSH]
lokal Enterovirus B, Human/pathogenicity [MeSH]
lokal Myocarditis/virology [MeSH]
lokal Anti-Inflammatory Agents/pharmacology [MeSH]
lokal Myeloid Cells/drug effects [MeSH]
lokal Proteolysis [MeSH]
lokal Coxsackievirus Infections/immunology [MeSH]
lokal Proteasome Endopeptidase Complex/genetics [MeSH]
lokal Cytokine
lokal Cells, Cultured [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/R29ldHprZSwgQ2FybCBDaHJpc3RvcGg=|https://frl.publisso.de/adhoc/uri/QWx0aG9mLCBOYWRpbmU=|https://frl.publisso.de/adhoc/uri/TmV1bWFpZXIsIEhhbm5haCBMb3Vpc2U=|https://frl.publisso.de/adhoc/uri/SGV1c2VyLCBBcm5kdA==|https://frl.publisso.de/adhoc/uri/S2F5YSwgWml5YQ==|https://frl.publisso.de/adhoc/uri/S2VzcG9obCwgTWVpa2U=|https://frl.publisso.de/adhoc/uri/S2xpbmdlbCwgS2FyaW4=|https://orcid.org/0000-0002-1826-5248
1000 Hinweis
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1000 Erstellt am 2023-05-11T10:57:34.103+0200
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1000 Zuletzt bearbeitet 2023-10-21T04:01:07.164+0200
1000 Objekt bearb. Sat Oct 21 04:01:07 CEST 2023
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