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1000 Titel
  • Occurrence of acute infarct-like myocarditis following COVID-19 vaccination: just an accidental co-incidence or rather vaccination-associated autoimmune myocarditis?
1000 Autor/in
  1. Chamling, Bishwas |
  2. Vehof, Volker |
  3. Drakos, Stefanos |
  4. Weil, Mareike |
  5. Stalling, Philipp |
  6. Vahlhaus, Christian |
  7. Mueller, Patrick |
  8. Bietenbeck, Michael |
  9. Reinecke, Holger |
  10. Meier, Claudia |
  11. Yilmaz, Ali |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-31
1000 Erschienen in
1000 Quellenangabe
  • 110(11):1850-1854
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00392-021-01916-w |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325525/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Objectives!#!Optimizing valve implantation depth (ID) plays a crucial role in minimizing conduction disturbances and achieving optimal functional integrity. Until now, the impact of intraprocedural fast (FP) or rapid ventricular pacing (RP) on the implantation depth has not been investigated. Therefore, we aimed to (1) evaluate the impact of different pacing maneuvers on ID, and (2) identify the independent predictors of deep ID.!##!Methods!#!473 TAVR patients with newer-generation self-expanding devices were retrospectively enrolled and one-to-one propensity-score-matching was performed, resulting in a matching of 189 FP and RP patients in each cohort. The final ID was analyzed, and the underlying functional, anatomical, and procedural conditions were evaluated by univariate and multivariate analysis.!##!Results!#!The highest ID was reached under RP in severe aortic valve calcification and valve size 26 mm. Multivariate analysis identified left ventricular outflow (LVOT) calcification [OR 0.50 (0.31-0.81) p = 0.005*], a 'flare' aortic root [OR 0.42 (0.25-0.71), p = 0.001*], and RP (OR 0.49 [0.30-0.79], p = 0.004*) as independent highly preventable predictors of a deep ID. In a model of protective factors, ID was significantly reduced with the number of protective criteria (0-2 criteria: - 5.7 mm ± 2.6 vs. 3-4 criteria - 4.3 mm ± 2.0; p < 0.0001*).!##!Conclusion!#!Data from this retrospective analysis indicate that RP is an independent predictor to reach a higher implantation depth using self-expanding devices. Randomized studies should prove for validation compared to fast and non-pacing maneuvers during valve delivery and their impact on implantation depth.!##!Trail registration!#!Clinical Trial registration: NCT01805739.!##!Study design!#!Evaluation of the impact of different pacing maneuvers (fast ventricular pacing-FP vs. rapid ventricular pacing-RP) on implantation depth (ID). After one-to-one-propensity-score-matching, independent protective and risk factors for a very deep ID beneath 6 mm toward the LVOT (< - 6 mm) were identified. Stent frame pictures as a courtesy by Medtronic
1000 Sacherschließung
lokal COVID-19 Vaccines/administration
gnd 1206347392 COVID-19
lokal COVID-19 vaccination
lokal Female [MeSH]
lokal Aged [MeSH]
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Autoimmune Diseases/diagnosis [MeSH]
lokal Myocarditis
lokal Autoimmune Diseases/etiology [MeSH]
lokal CMR
lokal COVID-19 Vaccines/adverse effects [MeSH]
lokal Letter to the Editors
lokal Young Adult [MeSH]
lokal Myocarditis/etiology [MeSH]
lokal Myocarditis/diagnosis [MeSH]
lokal Side effect
lokal Vaccination/adverse effects [MeSH]
lokal Myocardial infarction
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-3101-343X|https://frl.publisso.de/adhoc/uri/VmVob2YsIFZvbGtlcg==|https://frl.publisso.de/adhoc/uri/RHJha29zLCBTdGVmYW5vcw==|https://frl.publisso.de/adhoc/uri/V2VpbCwgTWFyZWlrZQ==|https://frl.publisso.de/adhoc/uri/U3RhbGxpbmcsIFBoaWxpcHA=|https://frl.publisso.de/adhoc/uri/VmFobGhhdXMsIENocmlzdGlhbg==|https://frl.publisso.de/adhoc/uri/TXVlbGxlciwgUGF0cmljaw==|https://frl.publisso.de/adhoc/uri/QmlldGVuYmVjaywgTWljaGFlbA==|https://frl.publisso.de/adhoc/uri/UmVpbmVja2UsIEhvbGdlcg==|https://frl.publisso.de/adhoc/uri/TWVpZXIsIENsYXVkaWE=|https://frl.publisso.de/adhoc/uri/WWlsbWF6LCBBbGk=
1000 Hinweis
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1000 Erstellt am 2023-05-11T11:24:55.879+0200
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1000 Zuletzt bearbeitet 2023-10-14T01:09:18.093+0200
1000 Objekt bearb. Sat Oct 14 01:09:18 CEST 2023
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