Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling

  1. Kresbach, Catena
  2. Bronsema, Annika
  3. Guerreiro, Helena
  4. Rutkowski, Stefan
  5. Schüller, Ulrich
  6. Winkler, Beate ORCID logo

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1000 Titel
  • Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling
1000 Autor/in
  1. Kresbach, Catena |
  2. Bronsema, Annika |
  3. Guerreiro, Helena |
  4. Rutkowski, Stefan |
  5. Schüller, Ulrich |
  6. Winkler, Beate |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-26
1000 Erschienen in
1000 Quellenangabe
  • 38(2):479-483
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00381-021-05278-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789637/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Glioblastoma (GBM) is an exceptionally aggressive brain tumor with a dismal prognosis, demanding fast and precise classification as a base for patient-specific treatment strategies. Here, we report on an adolescent patient with a histologically bona fide GBM that shows a molecular methylation profile suggesting a low-grade glioma-like subgroup. Despite an early relapse, intolerance of temozolomide, and change of treatment strategy to vinblastine and valproic acid (VPA), the patient is now in good clinical condition after more than 5 years since initial diagnosis. This case stresses the merit of methylation array data for clinical prognosis and treatment planning.
1000 Sacherschließung
lokal Adolescent [MeSH]
lokal Methylation [MeSH]
lokal Brain Neoplasms/genetics [MeSH]
lokal Humans [MeSH]
lokal Vinblastine
lokal Glioblastoma
lokal Glioblastoma/drug therapy [MeSH]
lokal Valproic Acid/therapeutic use [MeSH]
lokal Valproic acid
lokal Methylation profiling
lokal Prognosis [MeSH]
lokal Temozolomide/therapeutic use [MeSH]
lokal Brain Neoplasms/diagnostic imaging [MeSH]
lokal Brain Neoplasms/drug therapy [MeSH]
lokal Glioblastoma/diagnostic imaging [MeSH]
lokal Glioblastoma/genetics [MeSH]
lokal Case Report
lokal Vinblastine/therapeutic use [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/S3Jlc2JhY2gsIENhdGVuYQ==|https://frl.publisso.de/adhoc/uri/QnJvbnNlbWEsIEFubmlrYQ==|https://frl.publisso.de/adhoc/uri/R3VlcnJlaXJvLCBIZWxlbmE=|https://frl.publisso.de/adhoc/uri/UnV0a293c2tpLCBTdGVmYW4=|https://frl.publisso.de/adhoc/uri/U2Now7xsbGVyLCBVbHJpY2g=|https://orcid.org/0000-0002-4050-9819
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1000 Erstellt am 2023-05-11T12:03:51.001+0200
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1000 Zuletzt bearbeitet 2023-10-21T04:14:41.431+0200
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