Local radiotherapy and E7 RNA-LPX vaccination show enhanced therapeutic efficacy in preclinical models of HPV16+ cancer

  1. Salomon, Nadja
  2. Selmi, Abderaouf
  3. Grunwitz, Christian
  4. Kong, Anthony
  5. Stanganello, Eliana
  6. Neumaier, Jennifer
  7. Petschenka, Jutta
  8. Diken, Mustafa
  9. Kreiter, Sebastian
  10. Türeci, Özlem
  11. Sahin, Ugur
  12. Vascotto, Fulvia ORCID logo

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WeightNameValue
1000 Titel
  • Local radiotherapy and E7 RNA-LPX vaccination show enhanced therapeutic efficacy in preclinical models of HPV16+ cancer
1000 Autor/in
  1. Salomon, Nadja |
  2. Selmi, Abderaouf |
  3. Grunwitz, Christian |
  4. Kong, Anthony |
  5. Stanganello, Eliana |
  6. Neumaier, Jennifer |
  7. Petschenka, Jutta |
  8. Diken, Mustafa |
  9. Kreiter, Sebastian |
  10. Türeci, Özlem |
  11. Sahin, Ugur |
  12. Vascotto, Fulvia |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-12-31
1000 Erschienen in
1000 Quellenangabe
  • 71(8):1975-1988
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00262-021-03134-9 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293862/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Human papilloma virus (HPV) infection is a causative agent for several cancers types (genital, anal and head and neck region). The HPV E6 and E7 proteins are oncogenic drivers and thus are ideal candidates for therapeutic vaccination. We recently reported that a novel ribonucleic acid lipoplex (RNA-LPX)-based HPV16 vaccine, E7 RNA-LPX, mediates regression of mouse HPV16
1000 Sacherschließung
lokal Female [MeSH]
lokal Mice, Inbred C57BL [MeSH]
lokal Humans [MeSH]
lokal Papillomavirus Infections [MeSH]
lokal Animals [MeSH]
lokal Human papillomavirus 16/genetics [MeSH]
lokal Oncogene Proteins, Viral/genetics [MeSH]
lokal Tumor environment
lokal Original Article
lokal HPV16 E6/E7 cancer
lokal Mice [MeSH]
lokal Papillomavirus E7 Proteins/genetics [MeSH]
lokal Anti-tumoral CD8
lokal RNA [MeSH]
lokal Local radiotherapy
lokal RNA vaccines
lokal Vaccination [MeSH]
lokal Papillomavirus Vaccines [MeSH]
lokal CD8-Positive T-Lymphocytes [MeSH]
lokal Uterine Cervical Neoplasms [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U2Fsb21vbiwgTmFkamE=|https://frl.publisso.de/adhoc/uri/U2VsbWksIEFiZGVyYW91Zg==|https://frl.publisso.de/adhoc/uri/R3J1bndpdHosIENocmlzdGlhbg==|https://frl.publisso.de/adhoc/uri/S29uZywgQW50aG9ueQ==|https://frl.publisso.de/adhoc/uri/U3RhbmdhbmVsbG8sIEVsaWFuYQ==|https://frl.publisso.de/adhoc/uri/TmV1bWFpZXIsIEplbm5pZmVy|https://frl.publisso.de/adhoc/uri/UGV0c2NoZW5rYSwgSnV0dGE=|https://frl.publisso.de/adhoc/uri/RGlrZW4sIE11c3RhZmE=|https://frl.publisso.de/adhoc/uri/S3JlaXRlciwgU2ViYXN0aWFu|https://frl.publisso.de/adhoc/uri/VMO8cmVjaSwgw5Z6bGVt|https://frl.publisso.de/adhoc/uri/U2FoaW4sIFVndXI=|https://orcid.org/0000-0002-9839-3484
1000 Hinweis
  • DeepGreen-ID: 1e6cca78a74146679019dc275c708d42 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 @id frl:6451409.rdf
1000 Erstellt am 2023-05-11T13:23:48.774+0200
1000 Erstellt von 322
1000 beschreibt frl:6451409
1000 Zuletzt bearbeitet 2023-10-24T07:48:08.329+0200
1000 Objekt bearb. Tue Oct 24 07:48:08 CEST 2023
1000 Vgl. frl:6451409
1000 Oai Id
  1. oai:frl.publisso.de:frl:6451409 |
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