Clinical determinants of long-term survival in metastatic uveal melanoma

  1. Koch, Elias A. T.
  2. Petzold, Anne
  3. Wessely, Anja
  4. Dippel, Edgar
  5. Erdmann, Michael
  6. Heinzerling, Lucie
  7. Hohberger, Bettina
  8. Knorr, Harald
  9. Leiter, Ulrike
  10. Meier, Friedegund
  11. Mohr, Peter
  12. Rahimi, Farnaz
  13. Schell, Beatrice
  14. Schlaak, Max
  15. Terheyden, Patrick
  16. Schuler-Thurner, Beatrice
  17. Ugurel, Selma
  18. Utikal, Jochen
  19. Vera, Julio
  20. Weichenthal, Michael
  21. Ziller, Fabian
  22. Berking, Carola
  23. Heppt, Markus V ORCID logo

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1000 Titel
  • Clinical determinants of long-term survival in metastatic uveal melanoma
1000 Autor/in
  1. Koch, Elias A. T. |
  2. Petzold, Anne |
  3. Wessely, Anja |
  4. Dippel, Edgar |
  5. Erdmann, Michael |
  6. Heinzerling, Lucie |
  7. Hohberger, Bettina |
  8. Knorr, Harald |
  9. Leiter, Ulrike |
  10. Meier, Friedegund |
  11. Mohr, Peter |
  12. Rahimi, Farnaz |
  13. Schell, Beatrice |
  14. Schlaak, Max |
  15. Terheyden, Patrick |
  16. Schuler-Thurner, Beatrice |
  17. Ugurel, Selma |
  18. Utikal, Jochen |
  19. Vera, Julio |
  20. Weichenthal, Michael |
  21. Ziller, Fabian |
  22. Berking, Carola |
  23. Heppt, Markus V |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-10-28
1000 Erschienen in
1000 Quellenangabe
  • 71(6):1467-1477
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00262-021-03090-4 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123041/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • This study aimed to identify prognostic factors in patients with metastatic uveal melanoma (UM) that were associated with long-term survival in a real-world setting. A total of 94 patients with metastatic UM were included from German skin cancer centers and the German national skin cancer registry (ADOReg). Data were analyzed for the response to treatment, progression-free survival, and overall survival (OS). Prognostic factors were explored with univariate Cox regression, log-rank, and χ2-tests. Identified factors were subsequently validated after the population was divided into two cohorts of short-term survival (< 2 years OS, cohort A, n = 50) and long-term survival (> 2 years OS, cohort B, n = 44). A poor ECOG performance status (hazard ratio [HR] 2.0, 95% confidence interval [CI] 1.0-3.9) and elevated serum LDH (HR 2.0, 95% CI 1.0-3.8) were associated with a poor OS, whereas a good response to immune checkpoint blockade (ICB, p < 0.001), radiation therapy (p < 0.001), or liver-directed treatments (p = 0.01) were associated with a prolonged OS. Long-term survivors (cohort B) showed a higher median number of organs affected by metastasis (p < 0.001), while patients with liver metastases only were more common in cohort A (40% vs. 9%; p = 0.002). A partial response to ICB was observed in 16% (12/73), being 21% (8/38) for combined ICB, 17% (1/6) for single CTLA4 inhibition, and 10% (3/29) for single PD1 inhibition. One complete response occurred in cohort B with combined ICB. We conclude that the response to ICB and the presence of extrahepatic disease were favorable prognostic factors for long-term survival.
1000 Sacherschließung
lokal Immune checkpoint blockade
lokal Humans [MeSH]
lokal Immune Checkpoint Inhibitors [MeSH]
lokal Retrospective Studies [MeSH]
lokal Skin Neoplasms/pathology [MeSH]
lokal Uveal Neoplasms [MeSH]
lokal Original Article
lokal Liver-directed treatment
lokal Long-term survival
lokal Uveal melanoma
lokal Melanoma/drug therapy [MeSH]
lokal Registry
lokal Liver metastases
1000 Liste der Beteiligten
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1000 Hinweis
  • DeepGreen-ID: ad28ecae593541bf96cc07bbb5dd9586 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-05-11T13:25:14.281+0200
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1000 Zuletzt bearbeitet Sat Oct 21 04:50:42 CEST 2023
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