Small cell lung cancer stem cells display mesenchymal properties and exploit immune checkpoint pathways in activated cytotoxic T lymphocytes

  1. Kursunel, M. Alper ORCID logo
  2. Taskiran, Ekim Z.
  3. Tavukcuoglu, Ece
  4. Yanik, Hamdullah
  5. Demirag, Funda
  6. Karaosmanoglu, Beren
  7. Ozbay, Feyza Gul
  8. Uner, Aysegul
  9. Esendagli, Dorina
  10. Kizilgoz, Derya
  11. Yilmaz, Ulku
  12. Esendagli, Gunes

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WeightNameValue
1000 Titel
  • Small cell lung cancer stem cells display mesenchymal properties and exploit immune checkpoint pathways in activated cytotoxic T lymphocytes
1000 Autor/in
  1. Kursunel, M. Alper |
  2. Taskiran, Ekim Z. |
  3. Tavukcuoglu, Ece |
  4. Yanik, Hamdullah |
  5. Demirag, Funda |
  6. Karaosmanoglu, Beren |
  7. Ozbay, Feyza Gul |
  8. Uner, Aysegul |
  9. Esendagli, Dorina |
  10. Kizilgoz, Derya |
  11. Yilmaz, Ulku |
  12. Esendagli, Gunes |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-06
1000 Erschienen in
1000 Quellenangabe
  • 71(2):445-459
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00262-021-02998-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783896/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Small cell lung cancer (SCLC) is an aggressive tumor type with early dissemination and distant metastasis capacity. Even though optimal chemotherapy responses are observed initially in many patients, therapy resistance is almost inevitable. Accordingly, SCLC has been regarded as an archetype for cancer stem cell (CSC) dynamics. To determine the immune-modulatory influence of CSC in SCLC, this study focused on the characterization of CD44
1000 Sacherschließung
lokal Neoplastic Stem Cells/pathology [MeSH]
lokal Cancer stem cell
lokal Neoplastic Stem Cells/metabolism [MeSH]
lokal Apoptosis [MeSH]
lokal B7-H1 Antigen/metabolism [MeSH]
lokal Original Article
lokal Tumor Cells, Cultured [MeSH]
lokal TIM-3
lokal Lung Neoplasms/immunology [MeSH]
lokal Small Cell Lung Carcinoma/pathology [MeSH]
lokal CD8-Positive T-Lymphocytes/immunology [MeSH]
lokal LAG3
lokal Mesenchymal Stem Cells/immunology [MeSH]
lokal Cell Proliferation [MeSH]
lokal Mesenchymal Stem Cells/pathology [MeSH]
lokal T-Lymphocytes, Cytotoxic/immunology [MeSH]
lokal Neoplastic Stem Cells/immunology [MeSH]
lokal Humans [MeSH]
lokal Small Cell Lung Carcinoma/metabolism [MeSH]
lokal Hyaluronan Receptors/metabolism [MeSH]
lokal Programmed Cell Death 1 Ligand 2 Protein/metabolism [MeSH]
lokal PD-1
lokal Mesenchymal Stem Cells/metabolism [MeSH]
lokal Immunotherapy
lokal Lung Neoplasms/pathology [MeSH]
lokal Lung cancer
lokal Lung Neoplasms/metabolism [MeSH]
lokal Small Cell Lung Carcinoma/immunology [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-2483-1920|https://frl.publisso.de/adhoc/uri/VGFza2lyYW4sIEVraW0gWi4=|https://frl.publisso.de/adhoc/uri/VGF2dWtjdW9nbHUsIEVjZQ==|https://frl.publisso.de/adhoc/uri/WWFuaWssIEhhbWR1bGxhaA==|https://frl.publisso.de/adhoc/uri/RGVtaXJhZywgRnVuZGE=|https://frl.publisso.de/adhoc/uri/S2FyYW9zbWFub2dsdSwgQmVyZW4=|https://frl.publisso.de/adhoc/uri/T3piYXksIEZleXphIEd1bA==|https://frl.publisso.de/adhoc/uri/VW5lciwgQXlzZWd1bA==|https://frl.publisso.de/adhoc/uri/RXNlbmRhZ2xpLCBEb3JpbmE=|https://frl.publisso.de/adhoc/uri/S2l6aWxnb3osIERlcnlh|https://frl.publisso.de/adhoc/uri/WWlsbWF6LCBVbGt1|https://frl.publisso.de/adhoc/uri/RXNlbmRhZ2xpLCBHdW5lcw==
1000 Hinweis
  • DeepGreen-ID: 64223da24d0c4310af3bf164b1742fe0 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-05-11T13:25:43.868+0200
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1000 Zuletzt bearbeitet 2023-10-21T04:50:55.822+0200
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