Identification of potential novel drug resistance mechanisms by genomic and transcriptomic profiling of colon cancer cells with p53 deletion

  1. Kadioglu, Onat
  2. Saeed, Mohamed
  3. Mahmoud, Nuha
  4. Azawi, Shaymaa
  5. Mrasek, Kristin
  6. Liehr, Thomas
  7. Efferth, Thomas ORCID logo

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1000 Titel
  • Identification of potential novel drug resistance mechanisms by genomic and transcriptomic profiling of colon cancer cells with p53 deletion
1000 Autor/in
  1. Kadioglu, Onat |
  2. Saeed, Mohamed |
  3. Mahmoud, Nuha |
  4. Azawi, Shaymaa |
  5. Mrasek, Kristin |
  6. Liehr, Thomas |
  7. Efferth, Thomas |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-01-30
1000 Erschienen in
1000 Quellenangabe
  • 95(3):959-974
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00204-021-02979-4 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904745/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • TP53 (p53) is a pivotal player in tumor suppression with fifty percent of all invasive tumors displaying mutations in the TP53 gene. In the present study, we characterized colon cancer cells (HCT116 p53 
1000 Sacherschließung
lokal Gene Expression Regulation, Neoplastic [MeSH]
lokal Disease Progression [MeSH]
lokal Cancer
lokal DNA Copy Number Variations/genetics [MeSH]
lokal Antineoplastic Agents/pharmacology [MeSH]
lokal Genomic instability
lokal Drug resistance
lokal DNA Repair/genetics [MeSH]
lokal Drug Resistance, Neoplasm/genetics [MeSH]
lokal HCT116 Cells [MeSH]
lokal Loss-of-function
lokal Gene Deletion [MeSH]
lokal Chromosome Aberrations [MeSH]
lokal Mutation [MeSH]
lokal Molecular Toxicology
lokal Humans [MeSH]
lokal Sequence Analysis, RNA [MeSH]
lokal Colonic Neoplasms/genetics [MeSH]
lokal Tumor Suppressor Protein p53/genetics [MeSH]
lokal Tumor suppressor
lokal Chromosomal aberrations
lokal Drug Resistance, Multiple/genetics [MeSH]
lokal Colonic Neoplasms/drug therapy [MeSH]
lokal Comparative Genomic Hybridization [MeSH]
lokal Transcriptomics
lokal Gene Expression Profiling [MeSH]
lokal Apoptosis/genetics [MeSH]
lokal In Situ Hybridization, Fluorescence [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/S2FkaW9nbHUsIE9uYXQ=|https://frl.publisso.de/adhoc/uri/U2FlZWQsIE1vaGFtZWQ=|https://frl.publisso.de/adhoc/uri/TWFobW91ZCwgTnVoYQ==|https://frl.publisso.de/adhoc/uri/QXphd2ksIFNoYXltYWE=|https://frl.publisso.de/adhoc/uri/TXJhc2VrLCBLcmlzdGlu|https://frl.publisso.de/adhoc/uri/TGllaHIsIFRob21hcw==|https://orcid.org/0000-0002-2637-1681
1000 Hinweis
  • DeepGreen-ID: ae241685b5604c46bd7a84836bf5a47c ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-05-11T14:31:31.132+0200
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1000 Zuletzt bearbeitet 2023-10-24T07:37:15.838+0200
1000 Objekt bearb. Tue Oct 24 07:37:15 CEST 2023
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  1. oai:frl.publisso.de:frl:6451705 |
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