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1000 Titel
  • Verzögerte Prostatektomie nach Active Surveillance – eine prospektive Patientenbeobachtung
1000 Titelzusatz
  • Deferred prostatectomy after active surveillance—results from a single center
1000 Autor/in
  1. Al-Kailani, Zaid |
  2. Linxweiler, Johannes |
  3. Siemer, Stefan |
  4. Stöckle, Michael |
  5. Saar, Matthias |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-11-08
1000 Erschienen in
1000 Quellenangabe
  • 61(7):753-758
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00120-021-01705-3 |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Follow-up during Active Surveillance (AS) may result in psychological burden and discomfort due to the constant clinical monitoring. Therefore, successful implementation of AS is to some extent a challenge for the patient and the caregiver.!##!Materials and methods!#!In this monocentric study, we analyzed the reasons for termination of AS and the rate of the postoperative adverse pathology (AP) in patients who underwent deferred radical prostatectomy (RP) after AS. These results were compared with AS candidates who underwent immediate RP. P-values were calculated with the Χ!##!Results!#!After 21 months of follow-up during AS, a deferred RP was performed in 74 patients. On the other hand, 214 patients underwent immediate RP. AP (Gleason score ≥7b, ≥pT3a, R1 and N+) was common in the AS group and this was statistically significant (45% vs. 29%, P-value <0.001).!##!Conclusion!#!These findings reflect many deficits in the current AS protocols. Using the available tools to apply AS in the routine clinical practice setting may be not adequate to afford oncological safety. This requires the development of new diagnostic tools like new imaging techniques and innovative biomarkers that provide the clinician with more accurate data about disease progression and subsequent help to achieve better outcomes in active surveillance candidates.
1000 Sacherschließung
lokal Deferred prostatectomy
lokal Upgrading
lokal Watchful Waiting [MeSH]
lokal Niedrig-Risiko-Prostatakarzinom
lokal Neoplasm Grading [MeSH]
lokal Prostate [MeSH]
lokal Humans [MeSH]
lokal Adverse pathology
lokal Prostate-Specific Antigen [MeSH]
lokal Low-risk prostate cancer
lokal Ungünstige Pathologie
lokal Verzögerter Prostatektomie
lokal Originalien
lokal Male [MeSH]
lokal Upstaging
lokal Prostatectomy/methods [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/QWwtS2FpbGFuaSwgWmFpZA==|https://frl.publisso.de/adhoc/uri/TGlueHdlaWxlciwgSm9oYW5uZXM=|https://frl.publisso.de/adhoc/uri/U2llbWVyLCBTdGVmYW4=|https://frl.publisso.de/adhoc/uri/U3TDtmNrbGUsIE1pY2hhZWw=|https://frl.publisso.de/adhoc/uri/U2FhciwgTWF0dGhpYXM=
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1000 Erstellt am 2023-05-12T10:47:37.491+0200
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1000 Zuletzt bearbeitet 2023-10-24T08:36:12.243+0200
1000 Objekt bearb. Tue Oct 24 08:36:12 CEST 2023
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