Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study

  1. Röhr, Susanne ORCID logo
  2. Pabst, Alexander
  3. Riedel-Heller, Steffi G.
  4. Jessen, Frank
  5. Turana, Yuda
  6. Handajani, Yvonne S.
  7. Brayne, Carol
  8. Matthews, Fiona E.
  9. Stephan, Blossom C. M.
  10. Lipton, Richard B.
  11. Katz, Mindy J.
  12. Wang, Cuiling
  13. Guerchet, Maëlenn
  14. Preux, Pierre-Marie
  15. Mbelesso, Pascal
  16. Ritchie, Karen
  17. Ancelin, Marie-Laure
  18. Carrière, Isabelle
  19. Guaita, Antonio
  20. Davin, Annalisa
  21. Vaccaro, Roberta
  22. Kim, Ki Woong
  23. Han, Ji Won
  24. Suh, Seung Wan
  25. Shahar, Suzana
  26. Din, Normah C.
  27. Vanoh, Divya
  28. van Boxtel, Martin
  29. Köhler, Sebastian
  30. Ganguli, Mary
  31. Jacobsen, Erin P.
  32. Snitz, Beth E.
  33. Anstey, Kaarin J.
  34. Cherbuin, Nicolas
  35. Kumagai, Shuzo
  36. Chen, Sanmei
  37. Narazaki, Kenji
  38. Ng, Tze Pin
  39. Gao, Qi
  40. Gwee, Xinyi
  41. Brodaty, Henry
  42. Kochan, Nicole A.
  43. Trollor, Julian
  44. Lobo, Antonio
  45. López-Antón, Raúl
  46. Santabárbara, Javier
  47. Crawford, John D.
  48. Lipnicki, Darren M.
  49. Sachdev, Perminder S.

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1000 Titel
  • Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study
1000 Autor/in
  1. Röhr, Susanne |
  2. Pabst, Alexander |
  3. Riedel-Heller, Steffi G. |
  4. Jessen, Frank |
  5. Turana, Yuda |
  6. Handajani, Yvonne S. |
  7. Brayne, Carol |
  8. Matthews, Fiona E. |
  9. Stephan, Blossom C. M. |
  10. Lipton, Richard B. |
  11. Katz, Mindy J. |
  12. Wang, Cuiling |
  13. Guerchet, Maëlenn |
  14. Preux, Pierre-Marie |
  15. Mbelesso, Pascal |
  16. Ritchie, Karen |
  17. Ancelin, Marie-Laure |
  18. Carrière, Isabelle |
  19. Guaita, Antonio |
  20. Davin, Annalisa |
  21. Vaccaro, Roberta |
  22. Kim, Ki Woong |
  23. Han, Ji Won |
  24. Suh, Seung Wan |
  25. Shahar, Suzana |
  26. Din, Normah C. |
  27. Vanoh, Divya |
  28. van Boxtel, Martin |
  29. Köhler, Sebastian |
  30. Ganguli, Mary |
  31. Jacobsen, Erin P. |
  32. Snitz, Beth E. |
  33. Anstey, Kaarin J. |
  34. Cherbuin, Nicolas |
  35. Kumagai, Shuzo |
  36. Chen, Sanmei |
  37. Narazaki, Kenji |
  38. Ng, Tze Pin |
  39. Gao, Qi |
  40. Gwee, Xinyi |
  41. Brodaty, Henry |
  42. Kochan, Nicole A. |
  43. Trollor, Julian |
  44. Lobo, Antonio |
  45. López-Antón, Raúl |
  46. Santabárbara, Javier |
  47. Crawford, John D. |
  48. Lipnicki, Darren M. |
  49. Sachdev, Perminder S. |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-12-18
1000 Erschienen in
1000 Quellenangabe
  • 12(1):167
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s13195-020-00734-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749505/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer's disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts.!##!Methods!#!We combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence.!##!Results!#!The sample comprised 39,387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI = 23.3-24.4%) and IRT (25.6%, 95%CI = 25.1-26.1%); however, prevalence estimates varied largely between studies (QH 6.1%, 95%CI = 5.1-7.0%, to 52.7%, 95%CI = 47.4-58.0%; IRT: 7.8%, 95%CI = 6.8-8.9%, to 52.7%, 95%CI = 47.4-58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, in Asian and Black African people compared to White people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades.!##!Conclusions!#!SCD is frequent in old age. Having a quarter of older individuals with SCD warrants further investigation of its significance, as a risk stage for AD and other dementias, and of ways to help individuals with SCD who seek medical advice. Moreover, a standardized instrument to measure SCD is needed to overcome the measurement variability currently dominant in the field.
1000 Sacherschließung
lokal Female [MeSH]
lokal Prevalence
lokal Cognitive Dysfunction/epidemiology [MeSH]
lokal Subjective cognitive decline
lokal Cohort study
lokal Humans [MeSH]
lokal Aging [MeSH]
lokal Middle Aged [MeSH]
lokal Cohort Studies [MeSH]
lokal Individual participant data
lokal Epidemiology
lokal Data harmonization
lokal Male [MeSH]
lokal Research
lokal Prevalence [MeSH]
lokal Neuropsychological Tests [MeSH]
1000 Liste der Beteiligten
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