Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort - A comparison to the EWGSOP2 cut-off points

  1. Huemer, Marie-Theres
  2. Kluttig, Alexander
  3. Fischer, Beate
  4. Ahrens, Wolfgang ORCID logo
  5. Castell, Stefanie
  6. Ebert, Nina
  7. Gastell, Sylvia
  8. Jöckel, Karl-Heinz
  9. Kaaks, Rudolf
  10. Karch, André
  11. Keil, Thomas
  12. Kemmling, Yvonne
  13. Krist, Lilian
  14. Leitzmann, Michael
  15. Lieb, Wolfgang
  16. Meinke-Franze, Claudia
  17. Michels, Karin B.
  18. Mikolajczyk, Rafael
  19. Velásquez, Ilais Moreno
  20. Pischon, Tobias
  21. Schipf, Sabine
  22. Schmidt, Börge
  23. Schöttker, Ben
  24. Schulze, Matthias B.
  25. Stocker, Hannah
  26. Teismann, Henning
  27. Wirkner, Kerstin
  28. Drey, Micheal
  29. Peters, Annette
  30. Thorand, Barbara

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1000 Titel
  • Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort - A comparison to the EWGSOP2 cut-off points
1000 Autor/in
  1. Huemer, Marie-Theres |
  2. Kluttig, Alexander |
  3. Fischer, Beate |
  4. Ahrens, Wolfgang |
  5. Castell, Stefanie |
  6. Ebert, Nina |
  7. Gastell, Sylvia |
  8. Jöckel, Karl-Heinz |
  9. Kaaks, Rudolf |
  10. Karch, André |
  11. Keil, Thomas |
  12. Kemmling, Yvonne |
  13. Krist, Lilian |
  14. Leitzmann, Michael |
  15. Lieb, Wolfgang |
  16. Meinke-Franze, Claudia |
  17. Michels, Karin B. |
  18. Mikolajczyk, Rafael |
  19. Velásquez, Ilais Moreno |
  20. Pischon, Tobias |
  21. Schipf, Sabine |
  22. Schmidt, Börge |
  23. Schöttker, Ben |
  24. Schulze, Matthias B. |
  25. Stocker, Hannah |
  26. Teismann, Henning |
  27. Wirkner, Kerstin |
  28. Drey, Micheal |
  29. Peters, Annette |
  30. Thorand, Barbara |
1000 Erscheinungsjahr 2023
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-01-23
1000 Erschienen in
1000 Quellenangabe
  • 52(1):afac324
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1093/ageing/afac324 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879709/ |
1000 Ergänzendes Material
  • https://academic.oup.com/ageing/article/52/1/afac324/6998045#supplementary-data |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: The European Working Group on Sarcopenia in Older People (EWGSOP) updated in 2018 the cut-off points for low grip strength to assess sarcopenia based on pooled data from 12 British studies. OBJECTIVE: Comparison of the EWGSOP2 cut-off points for low grip strength to those derived from a large German sample. METHODS: We assessed the grip strength distribution across age and derived low grip strength cut-off points for men and women (peak mean -2.5 × SD) based on 200,389 German National Cohort (NAKO) participants aged 19–75 years. In 1,012 Cooperative Health Research in the Region of Augsburg (KORA)-Age participants aged 65–93 years, we calculated the age-standardised prevalence of low grip strength and time-dependent sensitivity and specificity for all-cause mortality. RESULTS: Grip strength increased in the third and fourth decade of life and declined afterwards. Calculated cut-off points for low grip strength were 29 kg for men and 18 kg for women. In KORA-Age, the age-standardised prevalence of low grip strength was 1.5× higher for NAKO-derived (17.7%) compared to EWGSOP2 (11.7%) cut-off points. NAKO-derived cut-off points yielded a higher sensitivity and lower specificity for all-cause mortality. CONCLUSIONS: Cut-off points for low grip strength from German population-based data were 2 kg higher than the EWGSOP2 cut-off points. Higher cut-off points increase the sensitivity, thereby suggesting an intervention for more patients at risk, while other individuals might receive additional diagnostics/treatment without the urgent need. Research on the effectiveness of intervention in patients with low grip strength defined by different cut-off points is needed.
1000 Sacherschließung
lokal mortality
lokal cut-off points
lokal probable sarcopenia
lokal grip strength
lokal European Working Group on Sarcopenia in Older People (EWGSOP)
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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  1. Bundesministerium für Bildung und Forschung |
  2. Federal States of Germany |
  3. Helmholtz-Gemeinschaft |
  4. Helmholtz Zentrum München |
1000 Fördernummer
  1. 01ER1301A/B/C; 01ER1511D; 01ET0713; 01ET1003A
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    1000 Fördernummer 01ER1301A/B/C; 01ER1511D; 01ET0713; 01ET1003A
  2. 1000 joinedFunding-child
    1000 Förderer Federal States of Germany |
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    1000 Förderer Helmholtz-Gemeinschaft |
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    1000 Förderer Helmholtz Zentrum München |
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1000 Erstellt am 2023-05-15T11:03:14.093+0200
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