Immunoglobulin G N-Glycosylation Signatures in Incident Type 2 Diabetes and Cardiovascular Disease

  1. Birukov, Anna
  2. Plavša, Branimir
  3. Eichelman, Fabian
  4. Kuxhaus, Olga
  5. Hoshi, Rosangela Akemi
  6. Rudman, Nadja
  7. Štambuk, Tamara
  8. Trbojević-Akmačić, Irena
  9. Schiborn, Catarina
  10. Morze, Jakub
  11. Mihelčić, Matea
  12. Cindrić, Ana
  13. Liu, Yanyan
  14. Demler, Olga
  15. Perola, Markus
  16. Mora, Samia
  17. Schulze, Matthias B. ORCID logo
  18. Lauc, Gordan
  19. Wittenbecher, Clemens ORCID logo

WeightNameValue
1000 Titel
  • Immunoglobulin G N-Glycosylation Signatures in Incident Type 2 Diabetes and Cardiovascular Disease
1000 Autor/in
  1. Birukov, Anna |
  2. Plavša, Branimir |
  3. Eichelman, Fabian |
  4. Kuxhaus, Olga |
  5. Hoshi, Rosangela Akemi |
  6. Rudman, Nadja |
  7. Štambuk, Tamara |
  8. Trbojević-Akmačić, Irena |
  9. Schiborn, Catarina |
  10. Morze, Jakub |
  11. Mihelčić, Matea |
  12. Cindrić, Ana |
  13. Liu, Yanyan |
  14. Demler, Olga |
  15. Perola, Markus |
  16. Mora, Samia |
  17. Schulze, Matthias B. |
  18. Lauc, Gordan |
  19. Wittenbecher, Clemens |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-10-25
1000 Erschienen in
1000 Quellenangabe
  • 45(11):2729-2736
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679264/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • OBJECTIVE: N-glycosylation is a functional posttranslational modification of immunoglobulins (Igs). We hypothesized that specific IgG N-glycans are associated with incident type 2 diabetes and cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS: We performed case-cohort studies within the population-based European Prospective Investigation into Cancer and Nutrition (EPIC)–Potsdam cohort (2,127 in the type 2 diabetes subcohort [741 incident cases]; 2,175 in the CVD subcohort [417 myocardial infarction and stroke cases]). Relative abundances of 24 IgG N-glycan peaks (IgG-GPs) were measured by ultraperformance liquid chromatography, and eight glycosylation traits were derived based on structural similarity. End point–associated IgG-GPs were preselected with fractional polynomials, and prospective associations were estimated in confounder-adjusted Cox models. Diabetes risk associations were validated in three independent studies. RESULTS: After adjustment for confounders and multiple testing correction, IgG-GP7, IgG-GP8, IgG-GP9, IgG-GP11, and IgG-GP19 were associated with type 2 diabetes risk. A score based on these IgG-GPs was associated with a higher diabetes risk in EPIC-Potsdam and independent validation studies (843 total cases, 3,149 total non-cases, pooled estimate per SD increase 1.50 [95% CI 1.37–1.64]). Associations of IgG-GPs with CVD risk differed between men and women. In women, IgG-GP9 was inversely associated with CVD risk (hazard ratio [HR] per SD 0.80 [95% CI 0.65–0.98]). In men, a weighted score based on IgG-GP19 and IgG-GP23 was associated with higher CVD risk (HR per SD 1.47 [95% CI 1.20–1.80]). In addition, several derived traits were associated with cardiometabolic disease incidence. CONCLUSIONS: Selected IgG N-glycans are associated with cardiometabolic risk beyond classic risk factors, including clinical biomarkers.
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/QmlydWtvdiwgQW5uYQ==|https://frl.publisso.de/adhoc/uri/UGxhdsWhYSwgQnJhbmltaXI=|https://frl.publisso.de/adhoc/uri/RWljaGVsbWFuLCBGYWJpYW4=|https://frl.publisso.de/adhoc/uri/S3V4aGF1cywgT2xnYQ==|https://frl.publisso.de/adhoc/uri/SG9zaGksIFJvc2FuZ2VsYSBBa2VtaQ==|https://frl.publisso.de/adhoc/uri/UnVkbWFuLCBOYWRqYQ==|https://frl.publisso.de/adhoc/uri/xaB0YW1idWssIFRhbWFyYQ==|https://frl.publisso.de/adhoc/uri/VHJib2pldmnEhy1Ba21hxI1pxIcsIElyZW5h|https://frl.publisso.de/adhoc/uri/U2NoaWJvcm4sIENhdGFyaW5h|https://frl.publisso.de/adhoc/uri/TW9yemUsIEpha3Vi|https://frl.publisso.de/adhoc/uri/TWloZWzEjWnEhywgTWF0ZWE=|https://frl.publisso.de/adhoc/uri/Q2luZHJpxIcsIEFuYQ==|https://frl.publisso.de/adhoc/uri/TGl1LCBZYW55YW4=|https://frl.publisso.de/adhoc/uri/RGVtbGVyLCBPbGdh|https://frl.publisso.de/adhoc/uri/UGVyb2xhLCBNYXJrdXM=|https://frl.publisso.de/adhoc/uri/TW9yYSwgU2FtaWE=|https://orcid.org/0000-0002-0830-5277|https://frl.publisso.de/adhoc/uri/TGF1YywgR29yZGFu|https://orcid.org/0000-0001-7792-877X
1000 Label
1000 Förderer
  1. Fundação Lemann |
  2. European Union |
  3. Federal Ministry of Science, Germany |
  4. European Structural and Investment Funds: Research and Development |
  5. Deutsche Forschungsgemeinschaft |
  6. National Institute of Diabetes and Digestive and Kidney Diseases |
  7. National Heart, Lung, and Blood Institute |
  8. Croatian National Centre of Research Excellence |
  9. Centre of Competence |
  10. Bundesministerium für Bildung und Forschung |
  11. State of Brandenburg |
  12. European Community |
  13. Deutsche Krebshilfe |
  14. SciLifeLab & Wallenberg Data Driven Life Science Program |
  15. Horizon 2020 |
1000 Fördernummer
  1. -
  2. 05F02; SOC 95201408
  3. EA 9401
  4. -
  5. WI5132/1-1
  6. DK112940
  7. HL 117861; K24 HL136852; R01 HL134811
  8. KK.01.1.1.01.0010
  9. KK.01.2.2.03.0006
  10. 82DZD00302; 82DZD03D03
  11. 82DZD00302; 82DZD03D03
  12. 05F02; SOC 98200769
  13. 70-2488-Ha
  14. KAW 2020.0239
  15. 721815; 722095
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
  5. -
  6. -
  7. -
  8. -
  9. -
  10. -
  11. -
  12. -
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  14. -
  15. -
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Fundação Lemann |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer European Union |
    1000 Förderprogramm -
    1000 Fördernummer 05F02; SOC 95201408
  3. 1000 joinedFunding-child
    1000 Förderer Federal Ministry of Science, Germany |
    1000 Förderprogramm -
    1000 Fördernummer EA 9401
  4. 1000 joinedFunding-child
    1000 Förderer European Structural and Investment Funds: Research and Development |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer WI5132/1-1
  6. 1000 joinedFunding-child
    1000 Förderer National Institute of Diabetes and Digestive and Kidney Diseases |
    1000 Förderprogramm -
    1000 Fördernummer DK112940
  7. 1000 joinedFunding-child
    1000 Förderer National Heart, Lung, and Blood Institute |
    1000 Förderprogramm -
    1000 Fördernummer HL 117861; K24 HL136852; R01 HL134811
  8. 1000 joinedFunding-child
    1000 Förderer Croatian National Centre of Research Excellence |
    1000 Förderprogramm -
    1000 Fördernummer KK.01.1.1.01.0010
  9. 1000 joinedFunding-child
    1000 Förderer Centre of Competence |
    1000 Förderprogramm -
    1000 Fördernummer KK.01.2.2.03.0006
  10. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Bildung und Forschung |
    1000 Förderprogramm -
    1000 Fördernummer 82DZD00302; 82DZD03D03
  11. 1000 joinedFunding-child
    1000 Förderer State of Brandenburg |
    1000 Förderprogramm -
    1000 Fördernummer 82DZD00302; 82DZD03D03
  12. 1000 joinedFunding-child
    1000 Förderer European Community |
    1000 Förderprogramm -
    1000 Fördernummer 05F02; SOC 98200769
  13. 1000 joinedFunding-child
    1000 Förderer Deutsche Krebshilfe |
    1000 Förderprogramm -
    1000 Fördernummer 70-2488-Ha
  14. 1000 joinedFunding-child
    1000 Förderer SciLifeLab & Wallenberg Data Driven Life Science Program |
    1000 Förderprogramm -
    1000 Fördernummer KAW 2020.0239
  15. 1000 joinedFunding-child
    1000 Förderer Horizon 2020 |
    1000 Förderprogramm -
    1000 Fördernummer 721815; 722095
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6452654.rdf
1000 Erstellt am 2023-05-25T09:41:26.171+0200
1000 Erstellt von 317
1000 beschreibt frl:6452654
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet 2023-05-25T09:41:44.427+0200
1000 Objekt bearb. Thu May 25 09:41:44 CEST 2023
1000 Vgl. frl:6452654
1000 Oai Id
  1. oai:frl.publisso.de:frl:6452654 |
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