Genomic basis for skin phenotype and cold adaptation in the extinct Steller’s sea cow

  1. Le Duc, Diana ORCID logo
  2. Velluva, Akhil ORCID logo
  3. Cassatt-Johnstone, Molly ORCID logo
  4. Olsen, Remi-Andre
  5. Baleka, Sina ORCID logo
  6. Lin, Chen-Ching
  7. Lemke, Johannes ORCID logo
  8. Southon, John R.
  9. Burdin, Alexander ORCID logo
  10. Wang, Ming-Shan
  11. Grunewald, Sonja ORCID logo
  12. Rosendahl, Wilfried
  13. Joger, Ulrich
  14. Rutschmann, Sereina
  15. Hildebrandt, Thomas Bernd ORCID logo
  16. Fritsch, Guido ORCID logo
  17. Estes, James ORCID logo
  18. Kelso, Janet ORCID logo
  19. Dalén, Love ORCID logo
  20. Hofreiter, Michael ORCID logo
  21. Shapiro, Beth ORCID logo
  22. Schöneberg, Torsten ORCID logo

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WeightNameValue
1000 Titel
  • Genomic basis for skin phenotype and cold adaptation in the extinct Steller’s sea cow
1000 Autor/in
  1. Le Duc, Diana |
  2. Velluva, Akhil |
  3. Cassatt-Johnstone, Molly |
  4. Olsen, Remi-Andre |
  5. Baleka, Sina |
  6. Lin, Chen-Ching |
  7. Lemke, Johannes |
  8. Southon, John R. |
  9. Burdin, Alexander |
  10. Wang, Ming-Shan |
  11. Grunewald, Sonja |
  12. Rosendahl, Wilfried |
  13. Joger, Ulrich |
  14. Rutschmann, Sereina |
  15. Hildebrandt, Thomas Bernd |
  16. Fritsch, Guido |
  17. Estes, James |
  18. Kelso, Janet |
  19. Dalén, Love |
  20. Hofreiter, Michael |
  21. Shapiro, Beth |
  22. Schöneberg, Torsten |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-02-04
1000 Erschienen in
1000 Quellenangabe
  • 8(5):eabl6496
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1126/sciadv.abl6496 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816345/ |
1000 Ergänzendes Material
  • https://www.science.org/doi/10.1126/sciadv.abl6496#supplementary-materials |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Steller's sea cow, an extinct sirenian and one of the largest Quaternary mammals, was described by Georg Steller in 1741 and eradicated by humans within 27 years. Here, we complement Steller's descriptions with paleogenomic data from 12 individuals. We identified convergent evolution between Steller's sea cow and cetaceans but not extant sirenians, suggesting a role of several genes in adaptation to cold aquatic (or marine) environments. Among these are inactivations of lipoxygenase genes, which in humans and mouse models cause ichthyosis, a skin disease characterized by a thick, hyperkeratotic epidermis that recapitulates Steller's sea cows' reportedly bark-like skin. We also found that Steller's sea cows' abundance was continuously declining for tens of thousands of years before their description, implying that environmental changes also contributed to their extinction.
1000 Sacherschließung
lokal Female [MeSH]
lokal Mice [MeSH]
lokal Mammals [MeSH]
lokal Multidisciplinary
lokal Dugong [MeSH]
lokal Phenotype [MeSH]
lokal Cattle [MeSH]
lokal Animals [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-7289-2552|https://orcid.org/0000-0003-0859-3624|https://orcid.org/0000-0001-7278-8333|https://frl.publisso.de/adhoc/uri/T2xzZW4sIFJlbWktQW5kcmU=|https://orcid.org/0000-0002-8850-9420|https://frl.publisso.de/adhoc/uri/TGluLCBDaGVuLUNoaW5n|https://orcid.org/0000-0002-4435-6610|https://frl.publisso.de/adhoc/uri/U291dGhvbiwgSm9obiBSLg==|https://orcid.org/0000-0001-5701-1008|https://frl.publisso.de/adhoc/uri/V2FuZywgTWluZy1TaGFu|https://orcid.org/0000-0002-2165-6274|https://frl.publisso.de/adhoc/uri/Um9zZW5kYWhsLCBXaWxmcmllZA==|https://frl.publisso.de/adhoc/uri/Sm9nZXIsIFVscmljaA==|https://frl.publisso.de/adhoc/uri/UnV0c2NobWFubiwgU2VyZWluYQ==|https://orcid.org/0000-0001-8685-4733|https://orcid.org/0000-0002-1296-9586|https://orcid.org/0000-0002-3632-4555|https://orcid.org/0000-0002-3618-322X|https://orcid.org/0000-0001-8270-7613|https://orcid.org/0000-0003-0441-4705|https://orcid.org/0000-0002-2733-7776|https://orcid.org/0000-0001-5313-0237
1000 Label
1000 Förderer
  1. Science for Life Laboratory |
  2. Knut och Alice Wallenbergs Stiftelse |
  3. National Genomics Infrastructure |
  4. Vetenskapsrådet |
  5. Uppsala Multidisciplinary Center for Advanced Computational Science |
1000 Fördernummer
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  2. -
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1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Science for Life Laboratory |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Knut och Alice Wallenbergs Stiftelse |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer National Genomics Infrastructure |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Vetenskapsrådet |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Uppsala Multidisciplinary Center for Advanced Computational Science |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 Erstellt am 2023-06-07T08:09:11.750+0200
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1000 Zuletzt bearbeitet Wed Jun 07 08:27:33 CEST 2023
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