The interplay of family history of depression and early trauma: Associations with lifetime and current depression in the German National Cohort (NAKO)

  1. Streit, Fabian
  2. Völker, Maja P.
  3. Klinger-König, Johanna
  4. Zillich, Lea
  5. Frank, Josef
  6. Reinhard, Iris
  7. Foo, Jerome Clifford
  8. Witt, Stephanie
  9. Sirignano, Lea
  10. Becher, Heiko
  11. Obi, Nadia
  12. Riedel, Oliver ORCID logo
  13. Do, Stefanie
  14. Castell, Stefanie
  15. Hassenstein, Max J.
  16. Karch, André
  17. Stang, Andreas
  18. Schmidt, Börge
  19. Schikowski, Tamara
  20. Stahl-Pehe, Anna
  21. Brenner, Hermann
  22. Perna, Laura
  23. Greiser, Karin Halina
  24. Kaaks, Rudolf
  25. Michels, Karin
  26. Franzke, Claus-Werner
  27. Peters, Annette
  28. Fischer, Beate
  29. Konzok, Julian
  30. Mikolajczyk, Rafael
  31. Führer, Amand
  32. Keil, Thomas
  33. Fricke, Julia
  34. Willich, Stefan N.
  35. Pischon, Tobias
  36. Völzke, Henry
  37. Meinke-Franze, Claudia
  38. Hoffmann, Wolfgang
  39. Löffler, Markus
  40. Wirkner, Kerstin
  41. Berger, Klaus
  42. Grabe, Hans J.
  43. Rietschel, Marcella

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Streit-et-al_2023_The interplay of family history of depression and early trauma.pdf 4,76MB
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1000 Titel
  • The interplay of family history of depression and early trauma: Associations with lifetime and current depression in the German National Cohort (NAKO)
1000 Autor/in
  1. Streit, Fabian |
  2. Völker, Maja P. |
  3. Klinger-König, Johanna |
  4. Zillich, Lea |
  5. Frank, Josef |
  6. Reinhard, Iris |
  7. Foo, Jerome Clifford |
  8. Witt, Stephanie |
  9. Sirignano, Lea |
  10. Becher, Heiko |
  11. Obi, Nadia |
  12. Riedel, Oliver |
  13. Do, Stefanie |
  14. Castell, Stefanie |
  15. Hassenstein, Max J. |
  16. Karch, André |
  17. Stang, Andreas |
  18. Schmidt, Börge |
  19. Schikowski, Tamara |
  20. Stahl-Pehe, Anna |
  21. Brenner, Hermann |
  22. Perna, Laura |
  23. Greiser, Karin Halina |
  24. Kaaks, Rudolf |
  25. Michels, Karin |
  26. Franzke, Claus-Werner |
  27. Peters, Annette |
  28. Fischer, Beate |
  29. Konzok, Julian |
  30. Mikolajczyk, Rafael |
  31. Führer, Amand |
  32. Keil, Thomas |
  33. Fricke, Julia |
  34. Willich, Stefan N. |
  35. Pischon, Tobias |
  36. Völzke, Henry |
  37. Meinke-Franze, Claudia |
  38. Hoffmann, Wolfgang |
  39. Löffler, Markus |
  40. Wirkner, Kerstin |
  41. Berger, Klaus |
  42. Grabe, Hans J. |
  43. Rietschel, Marcella |
1000 Erscheinungsjahr 2023
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-05-23
1000 Erschienen in
1000 Quellenangabe
  • 3:1099235
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fepid.2023.1099235 |
1000 Ergänzendes Material
  • https://www.frontiersin.org/articles/10.3389/fepid.2023.1099235/full#h13 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • INTRODUCTION: Family history of depression and childhood maltreatment are established risk factors for depression. However, how these factors are interrelated and jointly influence depression risk is not well understood. The present study investigated (i) if childhood maltreatment is associated with a family history of depression (ii) if family history and childhood maltreatment are associated with increased lifetime and current depression, and whether both factors interact beyond their main effects, and (iii) if family history affects lifetime and current depression via childhood maltreatment. METHODS: Analyses were based on a subgroup of the first 100,000 participants of the German National Cohort (NAKO), with complete information (58,703 participants, mean age = 51.2 years, 53% female). Parental family history of depression was assessed via self-report, childhood maltreatment with the Childhood Trauma Screener (CTS), lifetime depression with self-reported physician's diagnosis and the Mini-International Neuropsychiatric Interview (MINI), and current depressive symptoms with the depression scale of the Patient Health Questionnaire (PHQ-9). Generalized linear models were used to test main and interaction effects. Mediation was tested using causal mediation analyses. RESULTS: Higher frequencies of the childhood maltreatment measures were found in subjects reporting a positive family history of depression. Family history and childhood maltreatment were independently associated with increased depression. No statistical interactions of family history and childhood maltreatment were found for the lifetime depression measures. For current depressive symptoms (PHQ-9 sum score), an interaction was found, with stronger associations of childhood maltreatment and depression in subjects with a positive family history. Childhood maltreatment was estimated to mediate 7%–12% of the effect of family history on depression, with higher mediated proportions in subjects whose parents had a depression onset below 40 years. Abuse showed stronger associations with family history and depression, and higher mediated proportions of family history effects on depression than neglect. DISCUSSION: The present study confirms the association of childhood maltreatment and family history with depression in a large population-based cohort. While analyses provide little evidence for the joint effects of both risk factors on depression beyond their individual effects, results are consistent with family history affecting depression via childhood maltreatment to a small extent.
1000 Sacherschließung
lokal genetics
lokal family history
lokal maltreatment
lokal childhood trauma
lokal depression
lokal abuse
lokal neglect
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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  2. The federal states |
  3. The Helmholtz Association |
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  1. 01ER1301A/B/C; 01ER1511D; 01ER1801A/B/C/D; 01EW1810; 01EW1904
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    1000 Förderer Bundesministerium für Bildung und Forschung |
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    1000 Fördernummer 01ER1301A/B/C; 01ER1511D; 01ER1801A/B/C/D; 01EW1810; 01EW1904
  2. 1000 joinedFunding-child
    1000 Förderer The federal states |
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  3. 1000 joinedFunding-child
    1000 Förderer The Helmholtz Association |
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