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1000 Titel
  • 1‐Chloro‐2,3‐epoxypropane (Epichlorohydrin) : BAT Value Documentation, 2017
1000 Titelzusatz
  • Assessment Values in Biological Material – 1‐Chloro‐2,3‐epoxypropane (Epichlorohydrin)
1000 Beteiligung
Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe (herausgebende Körperschaft) |
1000 Autor/in
  1. Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe |
  2. Göen, Thomas |
  3. Bader, Michael |
  4. Drexler, Hans |
  5. Hartwig, Andrea |
  6. MAK Commission |
1000 Erscheinungsjahr 2018
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-02-15
1000 Erschienen in
1000 Quellenangabe
  • 3(1):295-305
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Verlagsversion
  • https://doi.org/10.1002/3527600418.bb10689e2318 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated EKA (exposure equivalents for carcinogenic substances) for epichlorohydrin (CAS‐No 106‐89‐8) in 2017. Available publications are described in detail. In rodents, epichlorohydrin induces malignant lymphomas, hyperplasias, forestomach papillomas and carcinomas, subcutaneous fibromas and lung and pituitary tumours. Epichlorohydrin was classified in category 2 for carcinogenic substances. The substance can easily pass through the skin, so biological monitoring is indicated for a valid individual risk assessment. In several biomonitoring studies the mercapturic acids derivatives N‐acetyl‐S‐(3‐chloro‐2‐hydroxypropyl)‐L‐cysteine (CHPMA) and N‐acetyl‐S‐(2,3‐dihydroxypropyl)‐L‐cysteine (DHPMA) in urine as well as the hemoglobin adducts N‐(3‐chloro‐2‐hydroxypropyl)valine and N‐(2,3‐dihydroxypropyl)valine are suggested as biomarkers after epichlorohydrin exposure. Validated analytical procedures for their quantification are available. Data of a correlation of epichlorohydrin in the air and the CHPMA‐excretion in urine were considered for the evaluation of exposure equivalents for carcinogenic substances. Sampling time is at the end of exposure or end of shift and after long term exposure at the end of the shift after several shifts.
1000 Sacherschließung
lokal 1-chloro-2,3-epoxypropane
lokal epichlorohydrin
lokal 2-(chloromethyl)oxirane
lokal EKA (exposure equivalents for carcinogenic substances)
lokal Beurteilungswerte in biologischem Material
lokal biological tolerance value
lokal gamma-chloropropylene oxide
lokal occupational exposure
lokal BAT value
lokal Assessment Values in Biological Material
lokal (D,L)-alpha-epichlorohydrin
lokal toxicity
1000 Fächerklassifikation (DDC)
1000 DOI 10.4126/FRL01-006454451 |
1000 Liste der Beteiligten
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1000 Erstellt am 2023-08-23T09:19:33.538+0200
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1000 Zuletzt bearbeitet Wed Nov 29 17:02:08 CET 2023
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1000 Oai Id
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