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1000 Titel
  • Criteria for designation with an “H” : MAK Value Documentation, 2014
1000 Titelzusatz
  • MAK Value Documentations – Criteria for designation with an “H”
1000 Beteiligung
Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe (herausgebende Körperschaft) |
1000 Autor/in
  1. Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe |
  2. Hartwig, Andrea |
  3. MAK Commission |
1000 Erscheinungsjahr 2017
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-07-26
1000 Erschienen in
1000 Quellenangabe
  • 2(3):1112-1118
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Verlagsversion
  • https://doi.org/10.1002/3527600418.mb0hmrkkrie5617 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated criteria to designate substances with an “H” which can be absorbed via the skin in such amounts as to contribute significantly to systemic toxicity. Information on the uptake via the skin can be obtained from studies in humans, animals and from in vitro models preferably with human skin. Ideally, these data allow the calculation of a flux, i.e. the amount absorbed per cm2 skin and hour. If these experimental studies are lacking, fluxes based on physicochemical data are calculated with three mathematical models for an aqueous saturated solution or a read‐across to similar substances with a better database is used. For gaseous substances, the water solubility of the substance is calculated at a substance concentration in the gas phase that corresponds to the MAK value and the flux is modelled. An exposure time of one hour and an exposed skin area of 2000 cm2 which corresponds to the area of both hands and forearms is used as a practical exposure model for liquids. For gases, the exposure time is taken as 8 hours and the exposed skin area as 1.8 m2. With the obtained fluxes, the body burden is calculated and if it exceeds 25% of the chronic systemic NOAEL for workers, the substance is designated with an “H”. If the substance is genotoxic and no systemic NOAEL could be deduced, a qualitative proof of uptake is enough for the designation with an “H”.
1000 Sacherschließung
lokal maximum workplace concentration
lokal skin penetration
lokal evaluation
lokal occupational exposure
lokal MAK-Begründungen
lokal skin absorption
lokal MAK Value Documentations
lokal criteria
lokal exposure models
1000 Fächerklassifikation (DDC)
1000 DOI 10.4126/FRL01-006456411 |
1000 Liste der Beteiligten
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1000 Erstellt am 2023-08-25T07:44:17.000+0200
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1000 Zuletzt bearbeitet Wed Nov 29 19:32:51 CET 2023
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