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1000 Titel
  • Triethanolamine : MAK Value Documentation, 2010
1000 Titelzusatz
  • MAK Value Documentations – Triethanolamine
1000 Beteiligung
Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe (herausgebende Körperschaft) |
1000 Autor/in
  1. Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe |
  2. Hartwig, Andrea |
  3. MAK Commission |
1000 Erscheinungsjahr 2017
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-10-27
1000 Erschienen in
1000 Quellenangabe
  • 2(4):1568-1609
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Verlagsversion
  • https://doi.org/10.1002/3527600418.mb10271kske4817 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated triethanolamine [102‐71‐6], considering all toxicological endpoints. Available publications and unpublished study reports are described in detail. After single application, triethanolamine was not found to have any relevant irritation potential for the skin or mucous membranes. The systemic toxicity of triethanolamine via all routes of exposure is low. A 28‐day inhalation study in rats with aerosol exposure revealed a LOAEC of 20 mg/m3 for inflammation of the larynx, the most sensitive toxicological end point. A benchmark calculation for focal laryngeal inflammation yielded a BMDL of 14.8 mg/m3 for male rats and 14.1 mg/m3 for female rats and the maximum concentration at the work place (MAK value) is set at 5 mg/m3 which also provides protection from systemic effects caused by triethanolamine. Since the critical effect is local, Peak Limitation Category I is designated, with an excursion factor of 4 because the effects on the larynx were observed only after prolonged exposure to 20 mg/m3 and triethanolamine had, if at all, a very low acute irritative potency. There are no conclusive studies on developmental toxicity available. Triethanolamine is therefore classified in Pregnancy Risk Group D. Triethanolamine is not genotoxic in vitro or in vivo; there is no evidence of germ cell mutagenicity. Oral and dermal studies in rats and mice yielded no evidence of a carcinogenic potential. Skin contact is not expected to contribute significantly to systemic toxicity. The sensitizing potency of triethanolamine is only very slight. Triethanolamine has therefore not been designated with “Sh” or “Sa” (for substances which cause sensitization of the skin or airways).
1000 Sacherschließung
lokal trolamine
lokal MAK value
lokal fertility
lokal metabolism
lokal developmental toxicity
lokal hazardous substance
lokal allergenic effects
lokal peak limitation
lokal (sub)chronic toxicity
lokal triethanolamine
lokal tris(2-hydroxyethyl)amine
lokal toxicity
lokal carcinogenicity
lokal toxicokinetics
lokal absorption through the skin
lokal reproductive toxicity
lokal mechanism of action
lokal 102-71-6
lokal (sub)acute toxicity
lokal MAK Value Documentations
lokal germ cell mutagenicity
lokal maximum workplace concentration
lokal 2,2′,2′′-nitrilotriethanol
lokal genotoxicity
lokal irritation
lokal occupational exposure
lokal MAK-Begründungen
lokal prenatal toxicity
lokal sensitization
1000 Fächerklassifikation (DDC)
1000 DOI 10.4126/FRL01-006456717 |
1000 Liste der Beteiligten
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1000 Label
1000 Dateien
  1. Triethanolamine : MAK Value Documentation, 2010
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6456717.rdf
1000 Erstellt am 2023-08-25T09:12:17.339+0200
1000 Erstellt von 335
1000 beschreibt frl:6456717
1000 Zuletzt bearbeitet 2023-11-29T19:51:30.635+0100
1000 Objekt bearb. Wed Nov 29 19:51:30 CET 2023
1000 Vgl. frl:6456717
1000 Oai Id
  1. oai:frl.publisso.de:frl:6456717 |
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