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1000 Titel
  • 1‐Decanol : MAK Value Documentation in German language, 2017
1000 Titelzusatz
  • MAK-Begründungen – 1‐Decanol
1000 Beteiligung
Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe (herausgebende Körperschaft) |
1000 Autor/in
  1. Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe |
  2. Hartwig, Andrea |
  3. MAK Commission |
1000 Erscheinungsjahr 2017
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-05-31
1000 Erschienen in
1000 Quellenangabe
  • 2(2):516-536
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Verlagsversion
  • https://doi.org/10.1002/3527600418.mb11230kskd0063 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated 1‐decanol [112‐30‐1] to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. Critical effects are irritation and the tumour‐promoting potential on the skin. Neither appropriate data in humans nor inhalation or oral studies of 1‐decanol with animals are available for derivation of a MAK value. An 8‐week feeding study in Wistar rats with the structurally related 1‐dodecanol resulted in a NOAEL of 100 mg/kg body weight and day. The same NOAEL is assumed for 1‐decanol. From this NOAEL, the concentration in workplace air was calculated according to the Commission's procedure to be 245 mg 1‐decanol/m3. However, as 1‐decanol is irritating and there are no studies of effects in the respiratory tract, a comparison with structurally‐related substances is indicated as well. The RD50 values of 45 ml/m3 and 50 ml/m3 for 2‐ethylhexanol and 1‐octanol, respectively, are rather similar, which can also be assumed for 1‐decanol. Because of its similar irritating potency, the MAK value for 1‐decanol has been established at 10 ml/m3 in analogy to 2‐ethylhexanol. As local effects are critical, the substance is assigned to Peak Limitation Category I. The excursion factor of 2 is set in analogy to 2‐ethylhexanol. From a synopsis of all data, 1‐decanol is classified in Pregnancy Risk Group C, despite the small difference between MAK value and NOAEC of 15 ml/m3 for developmental toxicity. 1‐Decanol is not mutagenic in bacteria. There are no long‐term studies with 1‐decanol. Papillomas, squamous cell carcinomas and severe skin irritation occurred after 60‐week application to the skin of the mouse following initiation with 7,12‐dimethylbenz[a]anthracene. The maximum skin absorption of 10 mg is less than 25% of the systemically tolerable amount of 660 mg which is taken up by inhalation at the MAK value. There are no positive clinical findings of contact sensitization from 1‐decanol, nor are such effects expected from the structure and the comparison with homologous alcohols. Data for sensitization of the airways are not available.
1000 Sacherschließung
lokal Decylalkohol
lokal 1-Decanol
lokal Genotoxizität
lokal Fertilität
lokal Reizwirkung
lokal fruchtschädigende Wirkung
lokal Toxikokinetik
lokal (sub)akute Toxizität
lokal Decan-1-ol
lokal Kanzerogenität
lokal keimzellmutagene Wirkung
lokal allergene Wirkung
lokal (sub)chronische Toxizität
lokal sensibilisierende Wirkung
lokal Toxizität
lokal krebserzeugende Wirkung
lokal Arbeitsstoff
lokal Entwicklungstoxizität
lokal Gefahrstoff
lokal MAK Value Documentations
lokal Reproduktionstoxizität
lokal MAK-Wert
lokal Kühlschmierstoff
lokal maximale Arbeitsplatzkonzentration
lokal MAK-Begründungen
lokal Caprinalkohol
lokal Hautresorption
lokal Metabolismus
lokal Spitzenbegrenzung
1000 Fächerklassifikation (DDC)
1000 DOI 10.4126/FRL01-006457507 |
1000 Liste der Beteiligten
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1000 Label
1000 Dateien
  1. 1‐Decanol : MAK Value Documentation in German language, 2017
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6457507.rdf
1000 Erstellt am 2023-08-28T09:09:34.559+0200
1000 Erstellt von 335
1000 beschreibt frl:6457507
1000 Zuletzt bearbeitet Wed Nov 29 21:00:22 CET 2023
1000 Objekt bearb. Wed Nov 29 21:00:22 CET 2023
1000 Vgl. frl:6457507
1000 Oai Id
  1. oai:frl.publisso.de:frl:6457507 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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