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1000 Titel
  • 2‐Phenoxyethanol : MAK Value Documentation, 2017 MAK Value Documentation, 2017
1000 Titelzusatz
  • MAK Value Documentations – 2‐Phenoxyethanol
1000 Beteiligung
Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe (herausgebende Körperschaft) |
1000 Autor/in
  1. Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe |
  2. Hartwig, Andrea |
  3. MAK Commission |
1000 Erscheinungsjahr 2019
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-01-30
1000 Erschienen in
1000 Quellenangabe
  • 4(1):73-116
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2019
1000 Verlagsversion
  • https://doi.org/10.1002/3527600418.mb12299kske6319 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated 2‐phenoxyethanol [122‐99‐6], considering all toxicity endpoints. Available publications and study reports are described in detail. In a 14‐day inhalation study with rats, critical effects of 2‐phenoxyethanol were hyperplasia, degeneration and metaplasia of the respiratory epithelium in the nasal cavity beginning at 246 mg/m3. The NOAEC was 48.2 mg/m3 (8.4 ml/m3). Since 2014, the Commission uses an empirical approach to set maximum concentrations at the workplace (MAK values) for substances with critical effects on the upper respiratory tract or the eyes. Based on this approach, a MAK value of 1 ml/m3 has been derived. The assignment to Peak Limitation Category I, because local effects are critical, and the excursion factor of 2 have been confirmed. No developmental toxicity was detected in rats (oral) or rabbits (dermal) up to doses of 1000 or 600 mg/kg body weight and day, resp. In an oral two‐generation study in mice, the NOAEL for foetotoxicity was about 400 mg/kg body weight and day. The differences between the NOAEL for rats, mice and rabbits scaled to an inhalation concentration at the workplace and the MAK value are considered so large that damage to the embryo or foetus is unlikely when the MAK value is observed. Therefore, classification in Pregnancy Risk Group C is confirmed. 2‐Phenoxyethanol is not regarded to be genotoxic or carcinogenic. Sensitization is not expected based on results of animal studies and experience in humans. Skin contact is not expected to contribute significantly to the systemic toxicity.
1000 Sacherschließung
lokal MAK value
lokal 2-phenoxyethanol
lokal fertility
lokal metabolism
lokal developmental toxicity
lokal hazardous substance
lokal allergenic effects
lokal peak limitation
lokal (sub)chronic toxicity
lokal toxicity
lokal carcinogenicity
lokal toxicokinetics
lokal absorption through the skin
lokal reproductive toxicity
lokal mechanism of action
lokal (sub)acute toxicity
lokal MAK Value Documentations
lokal germ cell mutagenicity
lokal maximum workplace concentration
lokal genotoxicity
lokal irritation
lokal occupational exposure
lokal MAK-Begründungen
lokal prenatal toxicity
lokal sensitization
1000 Fächerklassifikation (DDC)
1000 DOI 10.4126/FRL01-006457691 |
1000 Liste der Beteiligten
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1000 Oai Id
  1. oai:frl.publisso.de:frl:6457691 |
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