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1000
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Abstract/Summary
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The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the work place (MAK value), the Pregnancy Risk Group and the absorption through the skin of di(tert‐dodecyl)polysulfide [68583‐56‐2; 68425‐15‐0] (di(tert‐dodecyl)pentasulfide [31565‐23‐8]). The systemic toxicity is low and the substance is at most minimally irritating to skin and eye. Acidophilic globuli are present in the kidney of male rats in an oral 28‐day study at 50 mg/kg body weight and day, resulting from an α2u‐globulin mediated kidney toxicity which, however, is not relevant for humans. Based on this the NOAEL of 1000 mg/kg body weight and day, the MAK value would be 200 mg/m3. However, the substance isa poorly water‐soluble liquid and an accumulation in the lung is expected. Most of the molecule consists of hydrocarbon chains resulting in characteristics similar to severely refined mineral oil, for which a MAK value of 5 mg/m3 had been set as the respirable fraction (R) based on inhalation studies. Therefore, the MAK‐value for di(tert‐dodecyl)polysulfide is also set at 5 mg/m3 R. Peak Limitation is designated as well by analogy with severely refined mineral oil with Category II and excursion factor of 4. New data on developmental toxicity are not available. As the MAK value is lowered, Pregnancy Risk Group C is retained. Skin contact is not expected to contribute significantly to systemic toxicity.
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