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1000 Titel
  • Ethylenglykoldinitrat : MAK Value Documentation in German language, 2017
1000 Titelzusatz
  • MAK-Begründungen – Ethylenglykoldinitrat
1000 Beteiligung
Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe (herausgebende Körperschaft) |
1000 Autor/in
  1. Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe |
  2. Hartwig, Andrea |
  3. MAK Commission |
1000 Erscheinungsjahr 2017
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-05-31
1000 Erschienen in
1000 Quellenangabe
  • 2(2):562-576
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Verlagsversion
  • https://doi.org/10.1002/3527600418.mb62896d0063 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) of ethylene glycol dinitrate [628‐96‐6] of 0.05 ml/m3, considering all toxicity endpoints. A detailed description of the underlying studies is given. The critical effect in volunteers after a 25‐minute exposure to 0.05 ml/m3 of a mixture of ethylene glycol dinitrate and nitroglycerin was vasodilation, as indicated by the development of headaches or decreases in blood pressure. The effects were very slight. In occupational situations it is very difficult to assess the levels of exposure to ethylene glycol dinitrate that induce symptoms and effects, not only because exposure is usually to mixtures of organic nitrate esters, but also because of both respiratory tract and skin absorption of ethylene glycol dinitrate vapours. In workers, headaches were reported at nitroglycerin concentrations of 0.03 to 0.11 ml/m3 with a NOAEC below 0.01 ml/m3 nitroglycerin. Based on this data, the MAK value for nitroglycerin was established at 0.01 ml/m3. Because of the same mode of action and the similar LOAEC of the two substances, the MAK value for ethylene glycol dinitrate has been lowered to 0.01 ml/m3. The MAK value also applies to the sum of the concentrations of the two substances in the air. As systemic effects are critical, the assignment to Peak Limitation Category I and the excursion factor of 1, due to the short half‐life, are retained. Although there are no studies on developmental toxicity, ethylene glycol dinitrate is assigned to Pregnancy Risk Group C in analogy to nitroglycerin. No data are available for genotoxicity or carcinogenicity. Skin contact may contribute significantly to systemic toxicity and ethylene glycol dinitrate continues to be designated with an “H”. Sensitization is not expected from the limited data.
1000 Sacherschließung
lokal 2-Nitrooxyethylnitrat
lokal Reizwirkung
lokal fruchtschädigende Wirkung
lokal 628-96-6
lokal Glykoldinitrat
lokal Toxikokinetik
lokal 2-nitrooxyethyl nitrate
lokal (sub)akute Toxizität
lokal Ethan-1,2-diyldinitrat
lokal Ethylenglykoldinitrat
lokal keimzellmutagene Wirkung
lokal allergene Wirkung
lokal (sub)chronische Toxizität
lokal sensibilisierende Wirkung
lokal Toxizität
lokal krebserzeugende Wirkung
lokal Arbeitsstoff
lokal Gefahrstoff
lokal MAK Value Documentations
lokal Reproduktionstoxizität
lokal Dinitroglykol
lokal MAK-Wert
lokal Nitroglykol
lokal Wirkungsmechanismus
lokal maximale Arbeitsplatzkonzentration
lokal MAK-Begründungen
lokal EGDN
lokal Hautresorption
lokal Metabolismus
lokal Spitzenbegrenzung
1000 Fächerklassifikation (DDC)
1000 DOI 10.4126/FRL01-006459453 |
1000 Liste der Beteiligten
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1000 Erstellt am 2023-08-29T14:28:18.351+0200
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1000 Zuletzt bearbeitet 2023-11-29T23:34:32.559+0100
1000 Objekt bearb. Wed Nov 29 23:34:32 CET 2023
1000 Vgl. frl:6459453
1000 Oai Id
  1. oai:frl.publisso.de:frl:6459453 |
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