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1000 Titel
  • Nitroethane : MAK value documentation, 2017
1000 Titelzusatz
  • MAK Value Documentations – Nitroethane
1000 Beteiligung
Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe (herausgebende Körperschaft) |
1000 Autor/in
  1. Deutsche Forschungsgemeinschaft. Ständige Senatskommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe |
  2. Hartwig, Andrea |
  3. MAK Commission |
1000 Erscheinungsjahr 2019
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-07-25
1000 Erschienen in
1000 Quellenangabe
  • 4(3):1178-1200
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2019
1000 Verlagsversion
  • https://doi.org/10.1002/3527600418.mb7924e6319 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) for nitroethane [79‐24‐3], considering the endpoints local and systemic toxicity as well as developmental toxicity. Nitroethane acts locally as well as systemically. A 13‐week study in rats and mice found significantly increased methaemoglobin levels accompanied by changes in the spleen as critical effects. A NOAEC was not obtained. Based on the LOAEC of 100 ml/m3 and taking into consideration the higher sensitivity of humans and the possibility of effects increasing with time, the MAK value for nitroethane is lowered to 10 ml/m3. Degeneration, inflammation and hyperplasia of the olfactory epithelium occur at higher exposure concentrations. As the critical effect is systemic, the assignment to Peak Limitation Category II is retained as well as the excursion factor of 4. Because there are no studies on developmental toxicity with pure nitroethane, the assignment to Pregnancy Risk Group D is also confirmed. Skin contact may contribute significantly to systemic toxicity and nitroethane is designated with an “H”. Sensitization is not expected from the limited data.
1000 Sacherschließung
lokal 79-24-3
lokal 1-nitroethane
lokal MAK value
lokal fertility
lokal metabolism
lokal developmental toxicity
lokal hazardous substance
lokal allergenic effects
lokal peak limitation
lokal (sub)chronic toxicity
lokal mononitroethane
lokal toxicity
lokal carcinogenicity
lokal toxicokinetics
lokal absorption through the skin
lokal reproductive toxicity
lokal mechanism of action
lokal (sub)acute toxicity
lokal MAK Value Documentations
lokal germ cell mutagenicity
lokal maximum workplace concentration
lokal genotoxicity
lokal irritation
lokal occupational exposure
lokal MAK-Begründungen
lokal prenatal toxicity
lokal nitroethane
lokal sensitization
1000 Fächerklassifikation (DDC)
1000 DOI 10.4126/FRL01-006460926 |
1000 Liste der Beteiligten
  1. SGFydHdpZywgQW5kcmVh|TUFLIENvbW1pc3Npb24=
1000 Label
1000 Dateien
  1. Nitroethane : MAK value documentation, 2017
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6460926.rdf
1000 Erstellt am 2023-08-31T09:14:44.361+0200
1000 Erstellt von 335
1000 beschreibt frl:6460926
1000 Zuletzt bearbeitet Thu Nov 30 01:59:01 CET 2023
1000 Objekt bearb. Thu Nov 30 01:59:01 CET 2023
1000 Vgl. frl:6460926
1000 Oai Id
  1. oai:frl.publisso.de:frl:6460926 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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