m6A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma

  1. Fang, Han
  2. Sun, Qi
  3. Zhou, Jin
  4. Zhang, Huijuan
  5. Song, Qiong
  6. Zhang, Hua
  7. Yu, Guohua
  8. Guo, Ying
  9. Huang, Chengyu
  10. Mou, Yakui
  11. Jia, Chuanliang
  12. Song, Yingjian
  13. Liu, Aina
  14. Song, Kaiyu
  15. Lu, Congxian
  16. Tian, Ruxian
  17. Wei, Shizhuang
  18. Yang, Dengfeng
  19. Chen, Yixuan
  20. Li, Ting
  21. Wang, Kejian
  22. Yu, Yilan
  23. Lv, Yufeng
  24. Mo, Ke
  25. Sun, Ping
  26. Yu, Xiaofeng
  27. Song, Xicheng

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1000 Titel
  • m6A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma
1000 Autor/in
  1. Fang, Han |
  2. Sun, Qi |
  3. Zhou, Jin |
  4. Zhang, Huijuan |
  5. Song, Qiong |
  6. Zhang, Hua |
  7. Yu, Guohua |
  8. Guo, Ying |
  9. Huang, Chengyu |
  10. Mou, Yakui |
  11. Jia, Chuanliang |
  12. Song, Yingjian |
  13. Liu, Aina |
  14. Song, Kaiyu |
  15. Lu, Congxian |
  16. Tian, Ruxian |
  17. Wei, Shizhuang |
  18. Yang, Dengfeng |
  19. Chen, Yixuan |
  20. Li, Ting |
  21. Wang, Kejian |
  22. Yu, Yilan |
  23. Lv, Yufeng |
  24. Mo, Ke |
  25. Sun, Ping |
  26. Yu, Xiaofeng |
  27. Song, Xicheng |
1000 Erscheinungsjahr 2023
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-06-23
1000 Erschienen in
1000 Quellenangabe
  • 22(1):99
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12943-023-01791-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288689/ |
1000 Ergänzendes Material
  • https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-023-01791-1#Sec31 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Lung adenocarcinoma (LUAD) is a common type of lung cancer with a high risk of metastasis, but the exact molecular mechanisms of metastasis are not yet understood. METHODS: This study acquired single-cell transcriptomics profiling of 11 distal normal lung tissues, 11 primary LUAD tissues, and 4 metastatic LUAD tissues from the GSE131907 dataset. The lung multicellular ecosystems were characterized at a single-cell resolution, and the potential mechanisms underlying angiogenesis and metastasis of LUAD were explored. RESULTS: We constructed a global single-cell landscape of 93,610 cells from primary and metastatic LUAD and found that IGF2BP2 was specifically expressed both in a LUAD cell subpopulation (termed as LUAD_IGF2BP2), and an endothelial cell subpopulation (termed as En_IGF2BP2). The LUAD_IGF2BP2 subpopulation progressively formed and dominated the ecology of metastatic LUAD during metastatic evolution. IGF2BP2 was preferentially secreted by exosomes in the LUAD_IGF2BP2 subpopulation, which was absorbed by the En_IGF2BP2 subpopulation in the tumor microenvironment. Subsequently, IGF2BP2 improved the RNA stability of FLT4 through m6A modification, thereby activating the PI3K-Akt signaling pathway, and eventually promoting angiogenesis and metastasis. Analysis of clinical data showed that IGF2BP2 was linked with poor overall survival and relapse-free survival for LUAD patients. CONCLUSIONS: Overall, these findings provide a novel insight into the multicellular ecosystems of primary and metastatic LUAD, and demonstrate that a specific LUAD_IGF2BP2 subpopulation is a key orchestrator promoting angiogenesis and metastasis, with implications for the gene regulatory mechanisms of LUAD metastatic evolution, representing themselves as potential antiangiogenic targets.
1000 Sacherschließung
lokal N6-methyladenosine
lokal IGF2BP2
lokal Metastasis
lokal Exosomes
lokal Angiogenesis
lokal Single-cell RNA sequencing
lokal Lung adenocarcinoma
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/RmFuZywgSGFu|https://frl.publisso.de/adhoc/uri/U3VuLCBRaQ==|https://frl.publisso.de/adhoc/uri/WmhvdSwgSmlu|https://frl.publisso.de/adhoc/uri/WmhhbmcsIEh1aWp1YW4=|https://frl.publisso.de/adhoc/uri/U29uZywgUWlvbmc=|https://frl.publisso.de/adhoc/uri/WmhhbmcsIEh1YQ==|https://frl.publisso.de/adhoc/uri/WXUsIEd1b2h1YQ==|https://frl.publisso.de/adhoc/uri/R3VvLCBZaW5n|https://frl.publisso.de/adhoc/uri/SHVhbmcsIENoZW5neXU=|https://frl.publisso.de/adhoc/uri/TW91LCBZYWt1aQ==|https://frl.publisso.de/adhoc/uri/SmlhLCBDaHVhbmxpYW5n|https://frl.publisso.de/adhoc/uri/U29uZywgWWluZ2ppYW4=|https://frl.publisso.de/adhoc/uri/TGl1LCBBaW5h|https://frl.publisso.de/adhoc/uri/U29uZywgS2FpeXU=|https://frl.publisso.de/adhoc/uri/THUsIENvbmd4aWFu|https://frl.publisso.de/adhoc/uri/VGlhbiwgUnV4aWFu|https://frl.publisso.de/adhoc/uri/V2VpLCBTaGl6aHVhbmc=|https://frl.publisso.de/adhoc/uri/WWFuZywgRGVuZ2Zlbmc=|https://frl.publisso.de/adhoc/uri/Q2hlbiwgWWl4dWFu|https://frl.publisso.de/adhoc/uri/TGksIFRpbmc=|https://frl.publisso.de/adhoc/uri/V2FuZywgS2VqaWFu|https://frl.publisso.de/adhoc/uri/WXUsIFlpbGFu|https://frl.publisso.de/adhoc/uri/THYsIFl1ZmVuZw==|https://frl.publisso.de/adhoc/uri/IE1vLCBLZQ==|https://frl.publisso.de/adhoc/uri/U3VuLCBQaW5n|https://frl.publisso.de/adhoc/uri/WXUsIFhpYW9mZW5n|https://frl.publisso.de/adhoc/uri/U29uZywgWGljaGVuZw==
1000 Label
1000 Förderer
  1. Taishan Scholar Project of Shandong Province |
  2. The Natural Science Fund of Shandong Province |
  3. The Science and Technology Innovation Development Plan of Yantai |
  4. China Scholarship Council |
  5. The National Natural Science Fund of China |
  6. Key Technology Research and Development Program of Shandong Province |
1000 Fördernummer
  1. ts20190991
  2. ZR2021MH323
  3. 2022YD037
  4. 201909370036
  5. 82103646
  6. 2022CXPT023
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
  5. -
  6. Major Science and Technology Innovation Project
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Taishan Scholar Project of Shandong Province |
    1000 Förderprogramm -
    1000 Fördernummer ts20190991
  2. 1000 joinedFunding-child
    1000 Förderer The Natural Science Fund of Shandong Province |
    1000 Förderprogramm -
    1000 Fördernummer ZR2021MH323
  3. 1000 joinedFunding-child
    1000 Förderer The Science and Technology Innovation Development Plan of Yantai |
    1000 Förderprogramm -
    1000 Fördernummer 2022YD037
  4. 1000 joinedFunding-child
    1000 Förderer China Scholarship Council |
    1000 Förderprogramm -
    1000 Fördernummer 201909370036
  5. 1000 joinedFunding-child
    1000 Förderer The National Natural Science Fund of China |
    1000 Förderprogramm -
    1000 Fördernummer 82103646
  6. 1000 joinedFunding-child
    1000 Förderer Key Technology Research and Development Program of Shandong Province |
    1000 Förderprogramm Major Science and Technology Innovation Project
    1000 Fördernummer 2022CXPT023
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6461961.rdf
1000 Erstellt am 2023-09-26T15:11:40.500+0200
1000 Erstellt von 337
1000 beschreibt frl:6461961
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Wed Sep 27 08:12:42 CEST 2023
1000 Objekt bearb. Wed Sep 27 08:12:07 CEST 2023
1000 Vgl. frl:6461961
1000 Oai Id
  1. oai:frl.publisso.de:frl:6461961 |
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