Download
1-s2.0-S2213231723002045-main.pdf 2,87MB
WeightNameValue
1000 Titel
  • Prevention of colitis-induced liver oxidative stress and inflammation in a transgenic mouse model with increased omega-3 polyunsaturated fatty acids
1000 Autor/in
  1. Rohwer, Nadine |
  2. Jelleschitz, Julia |
  3. Höhn, Annika |
  4. Weber, Daniela |
  5. Kühl, Anja A. |
  6. Wang, Chaoxuan |
  7. Ohno, Rei-Ichi |
  8. Kampschulte, Nadja |
  9. Pietzner, Anne |
  10. Schebb, Nils Helge |
  11. Weylandt, Karsten-H. |
  12. Grune, Tilman |
1000 Erscheinungsjahr 2023
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-06-26
1000 Erschienen in
1000 Quellenangabe
  • 64:102803
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.redox.2023.102803 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336695/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Inflammatory bowel disease (IBD) is an immune-mediated gut dysfunction, which might also be associated with an inflammatory phenotype in the liver. It is known that the nutritional intake of omega-3 polyunsaturated fatty acids (n-3 PUFA) is inversely correlated to the severity and occurrence of IBD. In order to investigate whether n-3 PUFA can also reduce liver inflammation and oxidative liver damage due to colon inflammation, we explored the dextran sulfate sodium (DSS)-induced colitis model in wild-type and fat-1 mice with endogenously increased n-3 PUFA tissue content. Besides confirming previous data of alleviated DSS-induced colitis in the fat-1 mouse model, the increase of n-3 PUFA also resulted in a significant reduction of liver inflammation and oxidative damage in colitis-affected fat-1 mice as compared to wild-type littermates. This was accompanied by a remarkable increase of established inflammation-dampening n-3 PUFA oxylipins, namely docosahexaenoic acid-derived 19,20-epoxydocosapentaenoic acid and eicosapentaenoic acid-derived 15-hydroxyeicosapentaenoic acid and 17,18-epoxyeicosatetraenoic acid. Taken together, these observations demonstrate a strong inverse correlation between the anti-inflammatory lipidome derived from n-3 PUFA and the colitis-triggered inflammatory changes in the liver by reducing oxidative liver stress.
1000 Sacherschließung
lokal Liver inflammation
lokal mice
lokal Liver oxidative stress
lokal n-3 PUFA
lokal Colitis
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/Um9od2VyLCBOYWRpbmU=|https://frl.publisso.de/adhoc/uri/SmVsbGVzY2hpdHosIEp1bGlh|https://frl.publisso.de/adhoc/uri/SMO2aG4sIEFubmlrYQ==|https://frl.publisso.de/adhoc/uri/V2ViZXIsIERhbmllbGE=|https://frl.publisso.de/adhoc/uri/S8O8aGwsIEFuamEgQS4=|https://frl.publisso.de/adhoc/uri/V2FuZywgQ2hhb3h1YW4=|https://frl.publisso.de/adhoc/uri/T2hubywgUmVpLUljaGk=|https://frl.publisso.de/adhoc/uri/S2FtcHNjaHVsdGUsIE5hZGph|https://frl.publisso.de/adhoc/uri/UGlldHpuZXIsIEFubmU=|https://frl.publisso.de/adhoc/uri/U2NoZWJiLCBOaWxzIEhlbGdl|https://frl.publisso.de/adhoc/uri/V2V5bGFuZHQsIEthcnN0ZW4tSC4=|https://frl.publisso.de/adhoc/uri/R3J1bmUsIFRpbG1hbg==
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
  2. Ministry of Science, Research and Culture of the State of Brandenburg |
1000 Fördernummer
  1. GR1240/20-1; WE2908/13-1; 491394008
  2. -
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer GR1240/20-1; WE2908/13-1; 491394008
  2. 1000 joinedFunding-child
    1000 Förderer Ministry of Science, Research and Culture of the State of Brandenburg |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6462061.rdf
1000 Erstellt am 2023-10-16T11:21:30.575+0200
1000 Erstellt von 317
1000 beschreibt frl:6462061
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Mon Oct 16 11:22:53 CEST 2023
1000 Objekt bearb. Mon Oct 16 11:22:34 CEST 2023
1000 Vgl. frl:6462061
1000 Oai Id
  1. oai:frl.publisso.de:frl:6462061 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source