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1000 Titel
  • Spinal cord injury: molecular mechanisms and therapeutic interventions
1000 Autor/in
  1. Hu, Xiao |
  2. Xu, Wei |
  3. Ren, Yilong |
  4. Wang, Zhaojie |
  5. He, Xiaolie |
  6. Huang, Runzhi |
  7. Ma, Bei |
  8. Zhao, Jingwei |
  9. Zhu, Rongrong |
  10. Cheng, Liming |
1000 Erscheinungsjahr 2023
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-06-26
1000 Erschienen in
1000 Quellenangabe
  • 8(1):245
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41392-023-01477-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291001/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate. The challenges of SCI repair include its complex pathological mechanisms and the difficulties of neural regeneration in the central nervous system. In the past few decades, researchers have attempted to completely elucidate the pathological mechanism of SCI and identify effective strategies to promote axon regeneration and neural circuit remodeling, but the results have not been ideal. Recently, new pathological mechanisms of SCI, especially the interactions between immune and neural cell responses, have been revealed by single-cell sequencing and spatial transcriptome analysis. With the development of bioactive materials and stem cells, more attention has been focused on forming intermediate neural networks to promote neural regeneration and neural circuit reconstruction than on promoting axonal regeneration in the corticospinal tract. Furthermore, technologies to control physical parameters such as electricity, magnetism and ultrasound have been constantly innovated and applied in neural cell fate regulation. Among these advanced novel strategies and technologies, stem cell therapy, biomaterial transplantation, and electromagnetic stimulation have entered into the stage of clinical trials, and some of them have already been applied in clinical treatment. In this review, we outline the overall epidemiology and pathophysiology of SCI, expound on the latest research progress related to neural regeneration and circuit reconstruction in detail, and propose future directions for SCI repair and clinical applications.
1000 Sacherschließung
lokal Regeneration and repair in the nervous system
lokal Trauma
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/SHUsIFhpYW8=|https://frl.publisso.de/adhoc/uri/WHUsIFdlaQ==|https://frl.publisso.de/adhoc/uri/UmVuLCBZaWxvbmc=|https://frl.publisso.de/adhoc/uri/V2FuZywgWmhhb2ppZQ==|https://frl.publisso.de/adhoc/uri/SGUsIFhpYW9saWU=|https://frl.publisso.de/adhoc/uri/SHVhbmcsIFJ1bnpoaQ==|https://frl.publisso.de/adhoc/uri/TWEsIEJlaQ==|https://frl.publisso.de/adhoc/uri/WmhhbywgSmluZ3dlaQ==|https://frl.publisso.de/adhoc/uri/Wmh1LCBSb25ncm9uZw==|https://frl.publisso.de/adhoc/uri/Q2hlbmcsIExpbWluZw==
1000 Label
1000 Förderer
  1. National Key Research and Development Program of China |
  2. National Natural Science Foundation of China |
  3. National Natural Science Foundation of China |
1000 Fördernummer
  1. 2016YFA0100800;2021YFA1101301
  2. 82225027;81873994;81820108013;81901902;31727801;82202702;82202351
  3. 81330030
1000 Förderprogramm
  1. -
  2. -
  3. State Key Program
1000 Dateien
  1. Spinal cord injury: molecular mechanisms and therapeutic interventions
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer National Key Research and Development Program of China |
    1000 Förderprogramm -
    1000 Fördernummer 2016YFA0100800;2021YFA1101301
  2. 1000 joinedFunding-child
    1000 Förderer National Natural Science Foundation of China |
    1000 Förderprogramm -
    1000 Fördernummer 82225027;81873994;81820108013;81901902;31727801;82202702;82202351
  3. 1000 joinedFunding-child
    1000 Förderer National Natural Science Foundation of China |
    1000 Förderprogramm State Key Program
    1000 Fördernummer 81330030
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6462101.rdf
1000 Erstellt am 2023-10-20T14:34:35.115+0200
1000 Erstellt von 337
1000 beschreibt frl:6462101
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet 2023-10-24T08:49:40.324+0200
1000 Objekt bearb. Tue Oct 24 08:49:15 CEST 2023
1000 Vgl. frl:6462101
1000 Oai Id
  1. oai:frl.publisso.de:frl:6462101 |
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