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1000 Titel
  • Comparison of the composition of lymphocyte subpopulations in non-relapse and relapse patients with squamous cell carcinoma of the head and neck before, during radiochemotherapy and in the follow-up period: a multicenter prospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)
1000 Autor/in
  1. Niu, Minli |
  2. Combs, Stephanie E. |
  3. Linge, Annett |
  4. Krause, Mechthild |
  5. Baumann, Michael |
  6. Lohaus, Fabian |
  7. Ebert, Nadja |
  8. Tinhofer, Ingeborg |
  9. Budach, Volker |
  10. von der Grün, Jens |
  11. Rödel, Franz |
  12. Grosu, Anca-Ligia |
  13. Multhoff, Gabriele |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-31
1000 Erschienen in
1000 Quellenangabe
  • 16(1):141
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s13014-021-01868-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325802/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Radiochemotherapy (RCT) has been shown to induce changes in immune cell homeostasis which might affect antitumor immune responses. In the present study, we aimed to compare the composition and kinetics of major lymphocyte subsets in the periphery of patients with non-locoregional recurrent (n = 23) and locoregional recurrent (n = 9) squamous cell carcinoma of the head and neck (SCCHN) upon primary RCT.!##!Methods!#!EDTA-blood of non-locoregional recurrent SCCHN patients was collected before (t0), after application of 20-30 Gy (t1), in the follow-up period 3 (t2) and 6 months (t3) after RCT. In patients with locoregional recurrence blood samples were taken at t0, t1, t2 and at the time of recurrence (t5). EDTA-blood of age-related, healthy volunteers (n = 22) served as a control (Ctrl). Major lymphocyte subpopulations were phenotyped by multiparameter flow cytometry.!##!Results!#!Patients with non-recurrent SCCHN had significantly lower proportions of CD19!##!Conclusion!#!Monitoring the kinetics of lymphocyte subpopulations especially activatory NK cells before and after RCT might provide a clue with respect to the development of an early locoregional recurrence in patients with SCCHN. However, studies with larger patient cohorts are needed.!##!Trial registration!#!Observational Study on Biomarkers in Head and Neck Cancer (HNprädBio), NCT02059668. Registered on 11 February 2014, https://clinicaltrials.gov/ct2/show/NCT02059668 .
1000 Sacherschließung
lokal Aged, 80 and over [MeSH]
lokal Aged [MeSH]
lokal Squamous Cell Carcinoma of Head and Neck/pathology [MeSH]
lokal Lymphocyte subpopulations
lokal Neoplasm Recurrence, Local/pathology [MeSH]
lokal Prediction of locoregional recurrence
lokal Male [MeSH]
lokal Lymphocyte Subsets/immunology [MeSH]
lokal Killer Cells, Natural/immunology [MeSH]
lokal Case-Control Studies [MeSH]
lokal Squamous Cell Carcinoma of Head and Neck/therapy [MeSH]
lokal CD8-Positive T-Lymphocytes/immunology [MeSH]
lokal Neoplasm Recurrence, Local/therapy [MeSH]
lokal Head and Neck Neoplasms/immunology [MeSH]
lokal Female [MeSH]
lokal Follow-Up Studies [MeSH]
lokal Squamous Cell Carcinoma of Head and Neck/immunology [MeSH]
lokal Radiochemotherapy
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Prospective Studies [MeSH]
lokal Chemoradiotherapy/methods [MeSH]
lokal Head and Neck Neoplasms/therapy [MeSH]
lokal Clinical Radiation Oncology
lokal Middle Aged [MeSH]
lokal Neoplasm Recurrence, Local/immunology [MeSH]
lokal Immunophenotyping
lokal SCCHN
lokal Research
lokal Prognosis [MeSH]
lokal NK cell subsets
lokal Head and Neck Neoplasms/pathology [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-3870-6140|https://frl.publisso.de/adhoc/uri/Q29tYnMsIFN0ZXBoYW5pZSBFLg==|https://frl.publisso.de/adhoc/uri/TGluZ2UsIEFubmV0dA==|https://frl.publisso.de/adhoc/uri/S3JhdXNlLCBNZWNodGhpbGQ=|https://frl.publisso.de/adhoc/uri/QmF1bWFubiwgTWljaGFlbA==|https://frl.publisso.de/adhoc/uri/TG9oYXVzLCBGYWJpYW4=|https://frl.publisso.de/adhoc/uri/RWJlcnQsIE5hZGph|https://frl.publisso.de/adhoc/uri/VGluaG9mZXIsIEluZ2Vib3Jn|https://frl.publisso.de/adhoc/uri/QnVkYWNoLCBWb2xrZXI=|https://frl.publisso.de/adhoc/uri/dm9uIGRlciBHcsO8biwgSmVucw==|https://frl.publisso.de/adhoc/uri/UsO2ZGVsLCBGcmFueg==|https://frl.publisso.de/adhoc/uri/R3Jvc3UsIEFuY2EtTGlnaWE=|https://frl.publisso.de/adhoc/uri/TXVsdGhvZmYsIEdhYnJpZWxl
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