The East African Community (EAC) mobile laboratory networks in Kenya, Burundi, Tanzania, Rwanda, Uganda, and South Sudan—from project implementation to outbreak response against Dengue, Ebola, COVID-19, and epidemic-prone diseases

  1. Affara, Muna
  2. Lagu, Hakim Idris
  3. Achol, Emmanuel
  4. Karamagi, Richard
  5. Omari, Neema
  6. Ochido, Grace
  7. Kezakarayagwa, Eric
  8. Kabatesi, Francine
  9. Nkeshimana, Anatole
  10. Roba, Abdi
  11. Ndia, Millicent Nyakio
  12. Abudo, Mamo U.
  13. Kabanda, Alice
  14. Mpabuka, Etienne
  15. Mwikarago, Emil Ivan
  16. Kutjok, Philip Ezekiel
  17. Samson, Donald Duku
  18. Deng, Lul Lojok
  19. Moremi, Nyambura
  20. Kelly, Maria Ezekiely
  21. Mkama, Peter Bernard Mtesigwa
  22. Magesa, Alex
  23. Balinandi, Stephen Karabyo
  24. Pimundu, Godfrey
  25. Nabadda, Susan Ndidde
  26. Puradiredja, Dewi Ismajani
  27. Hinzmann, Julia
  28. Duraffour, Sophie
  29. Gabriel, Martin
  30. Ruge, Gerd
  31. Loag, Wibke
  32. Ayiko, Rogers
  33. Sonoiya, Stanley Serser
  34. May, Juergen
  35. Katende, Michael J.
  36. Gehre, Florian

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1000 Titel
  • The East African Community (EAC) mobile laboratory networks in Kenya, Burundi, Tanzania, Rwanda, Uganda, and South Sudan—from project implementation to outbreak response against Dengue, Ebola, COVID-19, and epidemic-prone diseases
1000 Autor/in
  1. Affara, Muna |
  2. Lagu, Hakim Idris |
  3. Achol, Emmanuel |
  4. Karamagi, Richard |
  5. Omari, Neema |
  6. Ochido, Grace |
  7. Kezakarayagwa, Eric |
  8. Kabatesi, Francine |
  9. Nkeshimana, Anatole |
  10. Roba, Abdi |
  11. Ndia, Millicent Nyakio |
  12. Abudo, Mamo U. |
  13. Kabanda, Alice |
  14. Mpabuka, Etienne |
  15. Mwikarago, Emil Ivan |
  16. Kutjok, Philip Ezekiel |
  17. Samson, Donald Duku |
  18. Deng, Lul Lojok |
  19. Moremi, Nyambura |
  20. Kelly, Maria Ezekiely |
  21. Mkama, Peter Bernard Mtesigwa |
  22. Magesa, Alex |
  23. Balinandi, Stephen Karabyo |
  24. Pimundu, Godfrey |
  25. Nabadda, Susan Ndidde |
  26. Puradiredja, Dewi Ismajani |
  27. Hinzmann, Julia |
  28. Duraffour, Sophie |
  29. Gabriel, Martin |
  30. Ruge, Gerd |
  31. Loag, Wibke |
  32. Ayiko, Rogers |
  33. Sonoiya, Stanley Serser |
  34. May, Juergen |
  35. Katende, Michael J. |
  36. Gehre, Florian |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-09
1000 Erschienen in
1000 Quellenangabe
  • 19(1):160
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12916-021-02028-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266482/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!East Africa is home to 170 million people and prone to frequent outbreaks of viral haemorrhagic fevers and various bacterial diseases. A major challenge is that epidemics mostly happen in remote areas, where infrastructure for Biosecurity Level (BSL) 3/4 laboratory capacity is not available. As samples have to be transported from the outbreak area to the National Public Health Laboratories (NPHL) in the capitals or even flown to international reference centres, diagnosis is significantly delayed and epidemics emerge.!##!Main text!#!The East African Community (EAC), an intergovernmental body of Burundi, Rwanda, Tanzania, Kenya, Uganda, and South Sudan, received 10 million € funding from the German Development Bank (KfW) to establish BSL3/4 capacity in the region. Between 2017 and 2020, the EAC in collaboration with the Bernhard-Nocht-Institute for Tropical Medicine (Germany) and the Partner Countries' Ministries of Health and their respective NPHLs, established a regional network of nine mobile BSL3/4 laboratories. These rapidly deployable laboratories allowed the region to reduce sample turn-around-time (from days to an average of 8h) at the centre of the outbreak and rapidly respond to epidemics. In the present article, the approach for implementing such a regional project is outlined and five major aspects (including recommendations) are described: (i) the overall project coordination activities through the EAC Secretariat and the Partner States, (ii) procurement of equipment, (iii) the established laboratory setup and diagnostic panels, (iv) regional training activities and capacity building of various stakeholders and (v) completed and ongoing field missions. The latter includes an EAC/WHO field simulation exercise that was conducted on the border between Tanzania and Kenya in June 2019, the support in molecular diagnosis during the Tanzanian Dengue outbreak in 2019, the participation in the Ugandan National Ebola response activities in Kisoro district along the Uganda/DRC border in Oct/Nov 2019 and the deployments of the laboratories to assist in SARS-CoV-2 diagnostics throughout the region since early 2020.!##!Conclusions!#!The established EAC mobile laboratory network allows accurate and timely diagnosis of BSL3/4 pathogens in all East African countries, important for individual patient management and to effectively contain the spread of epidemic-prone diseases.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal Viral haemorrhagic fevers
lokal Hemorrhagic Fever, Ebola/therapy [MeSH]
lokal COVID-19/therapy [MeSH]
lokal Uganda/epidemiology [MeSH]
lokal Laboratories [MeSH]
lokal Dengue/prevention
lokal Hemorrhagic Fever, Ebola/prevention
lokal Dengue/epidemiology [MeSH]
lokal Global Outbreaks and Responses
lokal Mobile laboratory
lokal Hemorrhagic Fever, Ebola/epidemiology [MeSH]
lokal SARS-CoV-2 [MeSH]
lokal Ebola virus disease
lokal South Sudan/epidemiology [MeSH]
lokal Dengue fever
lokal Outbreak response
lokal Rwanda/epidemiology [MeSH]
lokal Burundi/epidemiology [MeSH]
lokal Humans [MeSH]
lokal Epidemics [MeSH]
lokal East African Community
lokal COVID-19
lokal Community Networks [MeSH]
lokal Mobile Health Units/economics [MeSH]
lokal Kenya/epidemiology [MeSH]
lokal Capacity building
lokal Public Health [MeSH]
lokal COVID-19/prevention
lokal BSL4
lokal Correspondence
lokal Tanzania/epidemiology [MeSH]
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