The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study

  1. Flaatten, Hans
  2. Wernly, Bernhard
  3. Artigas, Antonio
  4. Beil, Michael
  5. van Heerden, Peter Vernon
  6. Szczeklik, Wojciech
  7. Elhadi, Muhammed
  8. Zafeiridis, Tilemachos
  9. Moreno, Rui
  10. Cecconi, Maurizio
  11. Boumendil, Ariane
  12. Abosheaishaa, Hazem Maarouf
  13. Abualqumboz, Enas M. Y.
  14. Ahmed, Abdullah Khudhur
  15. Ahmed, Hazem
  16. Aidoni, Zoi
  17. Aldecoa, Cesar
  18. Alexandru, Nica
  19. Ali, Yasmin Khairy NasrEldin Mohamed
  20. Al-Sadawi, Mohammed
  21. Andersen, Kasper
  22. Andersen, Finn H.
  23. Assis, Rui
  24. Azab, Mohammed A.
  25. Azzam, Ahmed Y.
  26. Badawy, Mohamed Raafat
  27. Balleby, Ida Riise
  28. Barth, Eberhard
  29. Ben-HAmouda, Nawfel
  30. Besch, Guillaume
  31. Besset, Sebastien
  32. Bjerregaard, Anders Thais
  33. Brix, Helene
  34. Bruno, Raphael Romano
  35. Brushoej, Jens
  36. Bundgaard, Helle
  37. Burtin, Philippe
  38. Caillard, Anais
  39. Canas-Perez, Isabel
  40. Charron, Cyril
  41. Chrisanthopoulou, Evangelia
  42. Comellini, Vittoria
  43. Cornet, Alex
  44. Cubero, Patricia Jimeno
  45. Czuczwar, Miroslaw
  46. Dauger, Stéphane
  47. Diaz-Rodriguez, Cristina
  48. Dieperink, Willem
  49. Dindane, Zouhir
  50. Djibré, Michel
  51. Dormans, Tom
  52. Dullenkopf, Alexander
  53. Dumas, Guillaume
  54. Elgazzar, Yumna A.
  55. Eller, Philipp
  56. Elsaka, Ahmed
  57. Evers, Mirjam
  58. Faltlhauser, Andreas
  59. Ferreira, Aida Fernández
  60. Fjølner, Jesper
  61. Fleury, Yvan
  62. Galbois, Arnaud
  63. Garcon, Pierre
  64. Garnier, Marc
  65. Gawda, Ryszard
  66. Ghannam, Abdelilah
  67. Goebel, Ulrich
  68. Gomà, Gemma
  69. Goncalves, Bruno
  70. Gordinho, André
  71. Groenendijk, Martijn
  72. Guerot, Emmanuel
  73. Guidet, Bertrand
  74. Gurjar, Mohan
  75. Haake, Hendrik
  76. Haas, Lenneke
  77. Habib, Ayman Abdelmawgoad
  78. Hahn, Michael
  79. Hansen, Maria Aagaard
  80. Hilles, Momin Majed Yousuf
  81. Hussein, Aliae A. R. Mohamed
  82. Iglesias, David
  83. Joannidis, Michael
  84. Jung, Christian
  85. Jurcisin, Igor
  86. Kabitz, Hans-Joachim
  87. Kelm, Malte
  88. Kindgen-Milles, Detlef
  89. Klimkiewicz, Jakub
  90. Kuhn, Karl Friedrich
  91. Kunstein, Anselm
  92. Kurt, Muhammed
  93. De Lange, Dylan W.
  94. Leaver, Susannah
  95. Lutz, Matthias
  96. Mahmoodpoor, Ata
  97. Maizel, Julien
  98. Marin, Nathalie
  99. Marsh, Brian
  100. Megarbane, Buno
  101. Mesotten, Dieter
  102. Meybohm, Patrick
  103. Meyer, Christian
  104. Mira, Angela Prado
  105. Namendys-Silva, Silvio a
  106. Nedergaard, Helene Korvenius
  107. Nseir, Saad
  108. Oeyen, Sandra
  109. Olasveengen, Theresa
  110. Oliveira, Ana Isabel Pinho
  111. Oziel, Johanna
  112. Papadogoulas, Antonios
  113. Perez-Torres, David
  114. Bollen Pinto, Bernardo
  115. Piton, Gaël
  116. Plantefeve, Gaëtan
  117. Poerner, Tudor
  118. Priego, Jesús
  119. Rabha, Ahmed
  120. Randerath, Winfried
  121. Raphaelen, Jean-herlé
  122. Reper, Pascal
  123. Rigaud, Jean-Philippe
  124. Rivera, Susana Arias
  125. Roberti, Andrea
  126. Romundstad, Luis
  127. Rovina, Nikoletta
  128. Salah, Rehab
  129. Saleh, Mahmoud
  130. Sancho, Susana
  131. de Lurdes Campos Santos, Maria
  132. Santos, Henrique
  133. Schaller, Stefan
  134. Schefold, Joerg C.
  135. Schuster, Michael
  136. Shala, Gonxhe
  137. Sjøbø, Britt
  138. Steiner, Stephan
  139. Strietzel, Hans Frank
  140. Sviri, Sigal
  141. Swinnen, Walter
  142. Tamayo-Lomas, Luis
  143. Tharwat, Samar
  144. Tomasa, Teresa
  145. Uhrenholt, Stine
  146. Vaissiere, Marie
  147. Valent, Arnaud
  148. Valette, Xavier
  149. Vanderlinden, Thierry
  150. Vázquez, Eric Mayor
  151. Villamayor, Mercedes Ibarz
  152. Villefrance, Maja
  153. Voigt, Ingo
  154. Wassim, Kyrillos
  155. Welte, Martin
  156. Wolff, Georg
  157. Wollborn, Jakob
  158. Zalba-Etayo, Begoña
  159. Zegers, Marieke

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1000 Titel
  • The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study
1000 Autor/in
  1. Flaatten, Hans |
  2. Wernly, Bernhard |
  3. Artigas, Antonio |
  4. Beil, Michael |
  5. van Heerden, Peter Vernon |
  6. Szczeklik, Wojciech |
  7. Elhadi, Muhammed |
  8. Zafeiridis, Tilemachos |
  9. Moreno, Rui |
  10. Cecconi, Maurizio |
  11. Boumendil, Ariane |
  12. Abosheaishaa, Hazem Maarouf |
  13. Abualqumboz, Enas M. Y. |
  14. Ahmed, Abdullah Khudhur |
  15. Ahmed, Hazem |
  16. Aidoni, Zoi |
  17. Aldecoa, Cesar |
  18. Alexandru, Nica |
  19. Ali, Yasmin Khairy NasrEldin Mohamed |
  20. Al-Sadawi, Mohammed |
  21. Andersen, Kasper |
  22. Andersen, Finn H. |
  23. Assis, Rui |
  24. Azab, Mohammed A. |
  25. Azzam, Ahmed Y. |
  26. Badawy, Mohamed Raafat |
  27. Balleby, Ida Riise |
  28. Barth, Eberhard |
  29. Ben-HAmouda, Nawfel |
  30. Besch, Guillaume |
  31. Besset, Sebastien |
  32. Bjerregaard, Anders Thais |
  33. Brix, Helene |
  34. Bruno, Raphael Romano |
  35. Brushoej, Jens |
  36. Bundgaard, Helle |
  37. Burtin, Philippe |
  38. Caillard, Anais |
  39. Canas-Perez, Isabel |
  40. Charron, Cyril |
  41. Chrisanthopoulou, Evangelia |
  42. Comellini, Vittoria |
  43. Cornet, Alex |
  44. Cubero, Patricia Jimeno |
  45. Czuczwar, Miroslaw |
  46. Dauger, Stéphane |
  47. Diaz-Rodriguez, Cristina |
  48. Dieperink, Willem |
  49. Dindane, Zouhir |
  50. Djibré, Michel |
  51. Dormans, Tom |
  52. Dullenkopf, Alexander |
  53. Dumas, Guillaume |
  54. Elgazzar, Yumna A. |
  55. Eller, Philipp |
  56. Elsaka, Ahmed |
  57. Evers, Mirjam |
  58. Faltlhauser, Andreas |
  59. Ferreira, Aida Fernández |
  60. Fjølner, Jesper |
  61. Fleury, Yvan |
  62. Galbois, Arnaud |
  63. Garcon, Pierre |
  64. Garnier, Marc |
  65. Gawda, Ryszard |
  66. Ghannam, Abdelilah |
  67. Goebel, Ulrich |
  68. Gomà, Gemma |
  69. Goncalves, Bruno |
  70. Gordinho, André |
  71. Groenendijk, Martijn |
  72. Guerot, Emmanuel |
  73. Guidet, Bertrand |
  74. Gurjar, Mohan |
  75. Haake, Hendrik |
  76. Haas, Lenneke |
  77. Habib, Ayman Abdelmawgoad |
  78. Hahn, Michael |
  79. Hansen, Maria Aagaard |
  80. Hilles, Momin Majed Yousuf |
  81. Hussein, Aliae A. R. Mohamed |
  82. Iglesias, David |
  83. Joannidis, Michael |
  84. Jung, Christian |
  85. Jurcisin, Igor |
  86. Kabitz, Hans-Joachim |
  87. Kelm, Malte |
  88. Kindgen-Milles, Detlef |
  89. Klimkiewicz, Jakub |
  90. Kuhn, Karl Friedrich |
  91. Kunstein, Anselm |
  92. Kurt, Muhammed |
  93. De Lange, Dylan W. |
  94. Leaver, Susannah |
  95. Lutz, Matthias |
  96. Mahmoodpoor, Ata |
  97. Maizel, Julien |
  98. Marin, Nathalie |
  99. Marsh, Brian |
  100. Megarbane, Buno |
  101. Mesotten, Dieter |
  102. Meybohm, Patrick |
  103. Meyer, Christian |
  104. Mira, Angela Prado |
  105. Namendys-Silva, Silvio a |
  106. Nedergaard, Helene Korvenius |
  107. Nseir, Saad |
  108. Oeyen, Sandra |
  109. Olasveengen, Theresa |
  110. Oliveira, Ana Isabel Pinho |
  111. Oziel, Johanna |
  112. Papadogoulas, Antonios |
  113. Perez-Torres, David |
  114. Bollen Pinto, Bernardo |
  115. Piton, Gaël |
  116. Plantefeve, Gaëtan |
  117. Poerner, Tudor |
  118. Priego, Jesús |
  119. Rabha, Ahmed |
  120. Randerath, Winfried |
  121. Raphaelen, Jean-herlé |
  122. Reper, Pascal |
  123. Rigaud, Jean-Philippe |
  124. Rivera, Susana Arias |
  125. Roberti, Andrea |
  126. Romundstad, Luis |
  127. Rovina, Nikoletta |
  128. Salah, Rehab |
  129. Saleh, Mahmoud |
  130. Sancho, Susana |
  131. de Lurdes Campos Santos, Maria |
  132. Santos, Henrique |
  133. Schaller, Stefan |
  134. Schefold, Joerg C. |
  135. Schuster, Michael |
  136. Shala, Gonxhe |
  137. Sjøbø, Britt |
  138. Steiner, Stephan |
  139. Strietzel, Hans Frank |
  140. Sviri, Sigal |
  141. Swinnen, Walter |
  142. Tamayo-Lomas, Luis |
  143. Tharwat, Samar |
  144. Tomasa, Teresa |
  145. Uhrenholt, Stine |
  146. Vaissiere, Marie |
  147. Valent, Arnaud |
  148. Valette, Xavier |
  149. Vanderlinden, Thierry |
  150. Vázquez, Eric Mayor |
  151. Villamayor, Mercedes Ibarz |
  152. Villefrance, Maja |
  153. Voigt, Ingo |
  154. Wassim, Kyrillos |
  155. Welte, Martin |
  156. Wolff, Georg |
  157. Wollborn, Jakob |
  158. Zalba-Etayo, Begoña |
  159. Zegers, Marieke |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-04-19
1000 Erschienen in
1000 Quellenangabe
  • 25(1):149
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s13054-021-03551-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054503/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in patients with COVID-19 is frailty. The degree of frailty could be used to assist both the triage into intensive care, and decisions regarding treatment limitations. Our study sought to determine the interaction of frailty and age in elderly COVID-19 ICU patients.!##!Methods!#!A prospective multicentre study of COVID-19 patients ≥ 70 years admitted to intensive care in 138 ICUs from 28 countries was conducted. The primary endpoint was 30-day mortality. Frailty was assessed using the clinical frailty scale. Additionally, comorbidities, management strategies and treatment limitations were recorded.!##!Results!#!The study included 1346 patients (28% female) with a median age of 75 years (IQR 72-78, range 70-96), 16.3% were older than 80 years, and 21% of the patients were frail. The overall survival at 30 days was 59% (95% CI 56-62), with 66% (63-69) in fit, 53% (47-61) in vulnerable and 41% (35-47) in frail patients (p < 0.001). In frail patients, there was no difference in 30-day survival between different age categories. Frailty was linked to an increased use of treatment limitations and less use of mechanical ventilation. In a model controlling for age, disease severity, sex, treatment limitations and comorbidities, frailty was independently associated with lower survival.!##!Conclusion!#!Frailty provides relevant prognostic information in elderly COVID-19 patients in addition to age and comorbidities. Trial registration Clinicaltrials.gov: NCT04321265 , registered 19 March 2020.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal Female [MeSH]
lokal Outcome
lokal Aged, 80 and over [MeSH]
lokal Aged [MeSH]
lokal Elderly
lokal Humans [MeSH]
lokal Prospective Studies [MeSH]
lokal Survival Analysis [MeSH]
lokal Frail Elderly/statistics
lokal COVID-19
lokal COVID-19/therapy [MeSH]
lokal Critical Care [MeSH]
lokal COVID-19/mortality [MeSH]
lokal Frailty/mortality [MeSH]
lokal Male [MeSH]
lokal Research
lokal Prognosis [MeSH]
lokal Frailty
lokal Pandemia
1000 Liste der Beteiligten
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1000 Hinweis
  • DeepGreen-ID: 0969716cfb6a4aef84a55c5b13099cba ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Dateien
1000 Objektart article
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1000 @id frl:6463899.rdf
1000 Erstellt am 2023-11-15T22:33:15.567+0100
1000 Erstellt von 322
1000 beschreibt frl:6463899
1000 Zuletzt bearbeitet 2023-11-30T22:34:58.021+0100
1000 Objekt bearb. Thu Nov 30 22:34:58 CET 2023
1000 Vgl. frl:6463899
1000 Oai Id
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