Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature

  1. Thomas-Rüddel, Daniel ORCID logo
  2. Hoffmann, Peter
  3. Komann, Marcus
  4. Lindner, Matthias
  5. Wetzker, Reinhard
  6. Bauer, Michael
  7. Reinhart, Konrad
  8. Marx, Gernot
  9. Schindler, Achim
  10. Schürholz, Tobias
  11. Schlegel-Höfner, Heike
  12. Lehmann, Gunther
  13. Sander, Annett
  14. Friese, Steffen
  15. Scholz, Christian
  16. Fischer, Pia
  17. Fuchs, Christina
  18. Becher, Lutz
  19. Salewsky, Norbert
  20. Schreiber, Torsten
  21. Goldmann, Anton
  22. Keh, Didier
  23. Schmid, Katrin
  24. Menning, Winfried
  25. Steuckart, Renate
  26. Barz, Robert
  27. Dey, Karin
  28. Fahrenholz, Meike
  29. Müller, Martin
  30. Gerlach, Herwig
  31. Toussaint, Susanne
  32. Brederlau, Jörg
  33. Bach, Friedhelm
  34. Buschmann, Dirk
  35. Gummelt, Ingo
  36. Hoeschen, J.
  37. Klaproth, Marion
  38. Vedder, Ina
  39. Bachmann-Holdau, Ulrike
  40. Eiche, Jürgen
  41. Hauschild, Rolf
  42. Lange, Martina
  43. Herrmann-Karbaum, Davia
  44. Lubasch, Annette
  45. Rücker, Marcus
  46. Icke, Christian
  47. Lucht, Alexander
  48. Meier-Hellmann, Andreas
  49. Wagner, Jan
  50. Arnold, Olaf
  51. Kästner, Steffen
  52. Clausen, Tobias
  53. Sternkopf, Michael
  54. Voswinckel, Robert
  55. Benndorf, T.
  56. Eiserloh, Christel
  57. Kuhnle, Gerhard
  58. Koch, Mathias
  59. Gerber, Manuela
  60. Gründling, Matthias
  61. Guderian, Liane
  62. Kuhn, Sven-Olaf
  63. Scheer, Christian
  64. Scheiber, Gerd
  65. Bloos, Frank
  66. Christink, Susann
  67. Kortegast, Martina
  68. Matthäus-Krämer, Claudia
  69. Mücke, Marcel
  70. Poidinger, Bernhard
  71. Rüddel, Hendrik
  72. Redlich, Ulrike
  73. Schwarzkopf, Daniel
  74. Thomas-Rüddel, Daniel
  75. Volkmer, Christel
  76. D’Aria, Stefanie
  77. Lemke, Thees
  78. Michaelsen, Birgit
  79. Schädler, Dirk
  80. Schulz-Ruhtenberg, Nina
  81. Weiler, Norbert
  82. Anetseder, Martin
  83. Textor, Zoran
  84. Kaisers, Udo
  85. Simon, Philipp
  86. Braun, Georg
  87. Jensen, Nicole
  88. Gegenfurtner, Werner
  89. Meinhardt, Alexander
  90. Schmitt, Robert
  91. Teichert, Andrea
  92. Becker, Klaus-Dieter
  93. Diers, Anja
  94. Jelschen, Florian
  95. Weyland, Andreas
  96. Knebel, Frieder
  97. Kupfer, Thomas
  98. Sinz, Rüdinger
  99. Bautz, Petra
  100. Fischer, Annemarie
  101. Seibel, Armin
  102. Fleischhacker, Christoph
  103. Häberle, Helene
  104. Henn, Philipp
  105. Mezger, Friederike
  106. Rosenberger, Peter
  107. Riessen, Reimer
  108. Ziegler, Silvia
  109. Barth, Eberhard
  110. Bracht, Hendrik
  111. Heymann, I.
  112. Hinder, A.
  113. Sens, R.
  114. Weiss, Manfred
  115. Lascho, Christof
  116. Micke, Henriette
  117. Schmidt, Falk
  118. Schilling, Stefanie
  119. Wöbker, Gabriele

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WeightNameValue
1000 Titel
  • Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature
1000 Autor/in
  1. Thomas-Rüddel, Daniel |
  2. Hoffmann, Peter |
  3. Komann, Marcus |
  4. Lindner, Matthias |
  5. Wetzker, Reinhard |
  6. Bauer, Michael |
  7. Reinhart, Konrad |
  8. Marx, Gernot |
  9. Schindler, Achim |
  10. Schürholz, Tobias |
  11. Schlegel-Höfner, Heike |
  12. Lehmann, Gunther |
  13. Sander, Annett |
  14. Friese, Steffen |
  15. Scholz, Christian |
  16. Fischer, Pia |
  17. Fuchs, Christina |
  18. Becher, Lutz |
  19. Salewsky, Norbert |
  20. Schreiber, Torsten |
  21. Goldmann, Anton |
  22. Keh, Didier |
  23. Schmid, Katrin |
  24. Menning, Winfried |
  25. Steuckart, Renate |
  26. Barz, Robert |
  27. Dey, Karin |
  28. Fahrenholz, Meike |
  29. Müller, Martin |
  30. Gerlach, Herwig |
  31. Toussaint, Susanne |
  32. Brederlau, Jörg |
  33. Bach, Friedhelm |
  34. Buschmann, Dirk |
  35. Gummelt, Ingo |
  36. Hoeschen, J. |
  37. Klaproth, Marion |
  38. Vedder, Ina |
  39. Bachmann-Holdau, Ulrike |
  40. Eiche, Jürgen |
  41. Hauschild, Rolf |
  42. Lange, Martina |
  43. Herrmann-Karbaum, Davia |
  44. Lubasch, Annette |
  45. Rücker, Marcus |
  46. Icke, Christian |
  47. Lucht, Alexander |
  48. Meier-Hellmann, Andreas |
  49. Wagner, Jan |
  50. Arnold, Olaf |
  51. Kästner, Steffen |
  52. Clausen, Tobias |
  53. Sternkopf, Michael |
  54. Voswinckel, Robert |
  55. Benndorf, T. |
  56. Eiserloh, Christel |
  57. Kuhnle, Gerhard |
  58. Koch, Mathias |
  59. Gerber, Manuela |
  60. Gründling, Matthias |
  61. Guderian, Liane |
  62. Kuhn, Sven-Olaf |
  63. Scheer, Christian |
  64. Scheiber, Gerd |
  65. Bloos, Frank |
  66. Christink, Susann |
  67. Kortegast, Martina |
  68. Matthäus-Krämer, Claudia |
  69. Mücke, Marcel |
  70. Poidinger, Bernhard |
  71. Rüddel, Hendrik |
  72. Redlich, Ulrike |
  73. Schwarzkopf, Daniel |
  74. Thomas-Rüddel, Daniel |
  75. Volkmer, Christel |
  76. D’Aria, Stefanie |
  77. Lemke, Thees |
  78. Michaelsen, Birgit |
  79. Schädler, Dirk |
  80. Schulz-Ruhtenberg, Nina |
  81. Weiler, Norbert |
  82. Anetseder, Martin |
  83. Textor, Zoran |
  84. Kaisers, Udo |
  85. Simon, Philipp |
  86. Braun, Georg |
  87. Jensen, Nicole |
  88. Gegenfurtner, Werner |
  89. Meinhardt, Alexander |
  90. Schmitt, Robert |
  91. Teichert, Andrea |
  92. Becker, Klaus-Dieter |
  93. Diers, Anja |
  94. Jelschen, Florian |
  95. Weyland, Andreas |
  96. Knebel, Frieder |
  97. Kupfer, Thomas |
  98. Sinz, Rüdinger |
  99. Bautz, Petra |
  100. Fischer, Annemarie |
  101. Seibel, Armin |
  102. Fleischhacker, Christoph |
  103. Häberle, Helene |
  104. Henn, Philipp |
  105. Mezger, Friederike |
  106. Rosenberger, Peter |
  107. Riessen, Reimer |
  108. Ziegler, Silvia |
  109. Barth, Eberhard |
  110. Bracht, Hendrik |
  111. Heymann, I. |
  112. Hinder, A. |
  113. Sens, R. |
  114. Weiss, Manfred |
  115. Lascho, Christof |
  116. Micke, Henriette |
  117. Schmidt, Falk |
  118. Schilling, Stefanie |
  119. Wöbker, Gabriele |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-10-21
1000 Erschienen in
1000 Quellenangabe
  • 25(1):368
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s13054-021-03776-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8532310/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates.!##!Methods!#!We did a secondary analysis of a large clinical dataset from a quality improvement trial. A binary logistic regression model was calculated to assess the association of the thermal response with outcome and a multinomial regression model to assess factors associated with fever or hypothermia.!##!Results!#!With 6542 analyzable cases we observed a bimodal temperature response characterized by fever or hypothermia, normothermia was rare. Hypothermia and high fever were both associated with higher lactate values. Hypothermia was associated with higher mortality, but this association was reduced after adjustment for other risk factors. Age, community-acquired sepsis, lower BMI and lower outside temperatures were associated with hypothermia while bacteremia and higher procalcitonin values were associated with high fever.!##!Conclusions!#!Septic patients show either a hypothermic or a fever response. Whether hypothermia is a maladaptive response, as indicated by the higher mortality in hypothermic patients, or an adaptive response in patients with limited metabolic reserves under colder environmental conditions, remains an open question. Trial registration The original trial whose dataset was analyzed was registered at ClinicalTrials.gov (NCT01187134) on August 23, 2010, the first patient was included on July 1, 2011.
1000 Sacherschließung
lokal Outcome
lokal Humans [MeSH]
lokal PCT
lokal Blood cultures
lokal Prognosis
lokal Sepsis/therapy [MeSH]
lokal Mortality
lokal Research
lokal Lactate
lokal Prognosis [MeSH]
lokal Hypothermia/complications [MeSH]
lokal Sepsis
lokal Fever/complications [MeSH]
lokal Body temperature
lokal Temperature [MeSH]
lokal Fever
1000 Liste der Beteiligten
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