Delayed skin reaction after mRNA-1273 vaccine against SARS-CoV-2: a rare clinical reaction

  1. Hoff, Norman-Philipp
  2. Freise, Noemi F.
  3. Schmidt, Albrecht G.
  4. Firouzi-Memarpuri, Parnian
  5. Reifenberger, Julia
  6. Luedde, Tom
  7. Boelke, Edwin ORCID logo
  8. Meller, Stephan
  9. Homey, Bernhard
  10. Feldt, Torsten
  11. Jensen, Björn Erik Ole
  12. Keitel, Verena
  13. Schmidt, Livia
  14. Maas, Kitti
  15. Haussmann, Jan
  16. Tamaskovics, Balint
  17. Budach, Wilfried
  18. Fischer, Johannes C.
  19. Buhren, Bettina Alexandra
  20. Knoefel, Wolfram Trudo
  21. Schneider, Marion
  22. Gerber, Peter Arne
  23. Pedoto, Alessia
  24. Häussinger, Dieter
  25. Grebe, Olaf
  26. van Griensven, Martijn
  27. Braun, Stephan A.
  28. Salzmann, Stefan
  29. Rezazadeh, Amir
  30. Matuschek, Christiane

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1000 Titel
  • Delayed skin reaction after mRNA-1273 vaccine against SARS-CoV-2: a rare clinical reaction
1000 Autor/in
  1. Hoff, Norman-Philipp |
  2. Freise, Noemi F. |
  3. Schmidt, Albrecht G. |
  4. Firouzi-Memarpuri, Parnian |
  5. Reifenberger, Julia |
  6. Luedde, Tom |
  7. Boelke, Edwin |
  8. Meller, Stephan |
  9. Homey, Bernhard |
  10. Feldt, Torsten |
  11. Jensen, Björn Erik Ole |
  12. Keitel, Verena |
  13. Schmidt, Livia |
  14. Maas, Kitti |
  15. Haussmann, Jan |
  16. Tamaskovics, Balint |
  17. Budach, Wilfried |
  18. Fischer, Johannes C. |
  19. Buhren, Bettina Alexandra |
  20. Knoefel, Wolfram Trudo |
  21. Schneider, Marion |
  22. Gerber, Peter Arne |
  23. Pedoto, Alessia |
  24. Häussinger, Dieter |
  25. Grebe, Olaf |
  26. van Griensven, Martijn |
  27. Braun, Stephan A. |
  28. Salzmann, Stefan |
  29. Rezazadeh, Amir |
  30. Matuschek, Christiane |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-08-25
1000 Erschienen in
1000 Quellenangabe
  • 26(1):98
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s40001-021-00557-z |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386154/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!The coronavirus disease 2019 (COVID-19) is associated with a wide clinical spectrum of skin manifestations, including urticarial, vesicular, vasculitic and chilblain-like lesions. Recently, delayed skin reactions have been reported in 1% individuals following mRNA vaccination against SARS-CoV-2. The exact pathophysiology and the risk factors still remain unclear.!##!Patients and methods!#!6821 employees and patients were vaccinated at our institutions between February and June 2021. Every patient received two doses of the mRNA-1273 vaccine in our hospitals, and reported back in case of any side effects which were collected in our hospital managed database.!##!Results!#!Eleven of 6821 vaccinated patients (0.16%) developed delayed skin reactions after either the first or second dose of the mRNA-1273 vaccine against SARS-CoV-2. Eight of 11 patients (73%) developed a rash after the first dose, while in 3/11 (27%), the rash occurred after the second dose. More females (9/11) were affected. Four of 11 patients required antihistamines, with two needing additional topical steroids. All the cutaneous manifestations resolved within 14 days. None of the skin reactions after the first dose of the vaccine prevented the administration of the second dose. There were no long-term cutaneous sequelae in any of the affected individuals.!##!Conclusion!#!Our data suggests that skin reactions after the use of mRNA-1273 vaccine against SARS-CoV-2 are possible, but rare. Further studies need to be done to understand the pathophysiology of these lesions.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal Aged [MeSH]
lokal Dermatitis
lokal Dermatitis/epidemiology [MeSH]
lokal Erythema
lokal COVID-19 Vaccines/adverse effects [MeSH]
lokal Dermatitis/etiology [MeSH]
lokal Male [MeSH]
lokal Vaccination/adverse effects [MeSH]
lokal Erythema/drug therapy [MeSH]
lokal Female [MeSH]
lokal Steroids/therapeutic use [MeSH]
lokal Erythema/epidemiology [MeSH]
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Inflammation
lokal Middle Aged [MeSH]
lokal COVID-19
lokal Erythema/etiology [MeSH]
lokal 2019-nCoV Vaccine mRNA-1273 [MeSH]
lokal Edema
lokal Histamine Antagonists/therapeutic use [MeSH]
lokal COVID-19/prevention
lokal Research
lokal Dermatitis/drug therapy [MeSH]
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1000 Erstellt am 2023-11-16T03:21:36.147+0100
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