Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases

  1. Biechele, Gloria
  2. Franzmeier, Nicolai
  3. Blume, Tanja
  4. Ewers, Michael
  5. Luque, Jose Medina
  6. Eckenweber, Florian
  7. Sacher, Christian
  8. Beyer, Leonie
  9. Ruch-Rubinstein, Francois
  10. Lindner, Simon
  11. Gildehaus, Franz-Josef
  12. von Ungern-Sternberg, Barbara
  13. Cumming, Paul
  14. Bartenstein, Peter
  15. Rominger, Axel
  16. Höglinger, Günter U.
  17. Herms, Jochen
  18. Brendel, Matthias ORCID logo

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1000 Titel
  • Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases
1000 Autor/in
  1. Biechele, Gloria |
  2. Franzmeier, Nicolai |
  3. Blume, Tanja |
  4. Ewers, Michael |
  5. Luque, Jose Medina |
  6. Eckenweber, Florian |
  7. Sacher, Christian |
  8. Beyer, Leonie |
  9. Ruch-Rubinstein, Francois |
  10. Lindner, Simon |
  11. Gildehaus, Franz-Josef |
  12. von Ungern-Sternberg, Barbara |
  13. Cumming, Paul |
  14. Bartenstein, Peter |
  15. Rominger, Axel |
  16. Höglinger, Günter U. |
  17. Herms, Jochen |
  18. Brendel, Matthias |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-12-14
1000 Erschienen in
1000 Quellenangabe
  • 17(1):374
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12974-020-02046-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737385/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!In vivo assessment of neuroinflammation by 18-kDa translocator protein positron-emission-tomography (TSPO-PET) ligands receives growing interest in preclinical and clinical research of neurodegenerative disorders. Higher TSPO-PET binding as a surrogate for microglial activation in females has been reported for cognitively normal humans, but such effects have not yet been evaluated in rodent models of neurodegeneration and their controls. Thus, we aimed to investigate the impact of sex on microglial activation in amyloid and tau mouse models and wild-type controls.!##!Methods!#!TSPO-PET (!##!Results!#!Wild-type mice showed an increased TSPO-PET signal over time (female +23%, male +4%), with a significant sex × age interaction (T = - 4.171, p < 0.001). The Aβ model App!##!Conclusion!#!Female mice indicate sex-dependent microglia activation in aging and in response to amyloidosis but not in response to tau pathology. This calls for consideration of sex difference in TSPO-PET studies of microglial activation in mouse models of neurodegeneration and by extension in human studies.
1000 Sacherschließung
lokal Mice, Inbred C57BL [MeSH]
lokal Aging/metabolism [MeSH]
lokal Neurodegenerative Diseases/metabolism [MeSH]
lokal Neuroglia/metabolism [MeSH]
lokal Amyloidosis/metabolism [MeSH]
lokal Mice, Transgenic [MeSH]
lokal Positron-Emission Tomography/methods [MeSH]
lokal Amyloid
lokal Male [MeSH]
lokal Sex Characteristics [MeSH]
lokal Disease Models, Animal [MeSH]
lokal tau Proteins/genetics [MeSH]
lokal Amyloidosis/genetics [MeSH]
lokal Female [MeSH]
lokal Microglia
lokal TSPO
lokal Neurodegenerative Diseases/pathology [MeSH]
lokal Animals [MeSH]
lokal Amyloidosis/pathology [MeSH]
lokal Neurodegenerative Diseases/genetics [MeSH]
lokal Mice [MeSH]
lokal Aging/pathology [MeSH]
lokal Sex
lokal Tau
lokal Research
lokal Neuroglia/pathology [MeSH]
lokal tau Proteins/metabolism [MeSH]
lokal Positron-Emission Tomography/trends [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/QmllY2hlbGUsIEdsb3JpYQ==|https://frl.publisso.de/adhoc/uri/RnJhbnptZWllciwgTmljb2xhaQ==|https://frl.publisso.de/adhoc/uri/Qmx1bWUsIFRhbmph|https://frl.publisso.de/adhoc/uri/RXdlcnMsIE1pY2hhZWw=|https://frl.publisso.de/adhoc/uri/THVxdWUsIEpvc2UgTWVkaW5h|https://frl.publisso.de/adhoc/uri/RWNrZW53ZWJlciwgRmxvcmlhbg==|https://frl.publisso.de/adhoc/uri/U2FjaGVyLCBDaHJpc3RpYW4=|https://frl.publisso.de/adhoc/uri/QmV5ZXIsIExlb25pZQ==|https://frl.publisso.de/adhoc/uri/UnVjaC1SdWJpbnN0ZWluLCBGcmFuY29pcw==|https://frl.publisso.de/adhoc/uri/TGluZG5lciwgU2ltb24=|https://frl.publisso.de/adhoc/uri/R2lsZGVoYXVzLCBGcmFuei1Kb3NlZg==|https://frl.publisso.de/adhoc/uri/dm9uIFVuZ2Vybi1TdGVybmJlcmcsIEJhcmJhcmE=|https://frl.publisso.de/adhoc/uri/Q3VtbWluZywgUGF1bA==|https://frl.publisso.de/adhoc/uri/QmFydGVuc3RlaW4sIFBldGVy|https://frl.publisso.de/adhoc/uri/Um9taW5nZXIsIEF4ZWw=|https://frl.publisso.de/adhoc/uri/SMO2Z2xpbmdlciwgR8O8bnRlciBVLg==|https://frl.publisso.de/adhoc/uri/SGVybXMsIEpvY2hlbg==|https://orcid.org/0000-0002-9247-2843
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1000 Erstellt am 2023-11-16T07:23:50.719+0100
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