Targeting the Inside of Cells with Biologicals: Chemicals as a Delivery Strategy

  1. Marschall, Andrea L. J. ORCID logo

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1000 Titel
  • Targeting the Inside of Cells with Biologicals: Chemicals as a Delivery Strategy
1000 Autor/in
  1. Marschall, Andrea L. J. |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-10-27
1000 Erschienen in
1000 Quellenangabe
  • 35(6):643-671
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s40259-021-00500-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548996/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Delivering macromolecules into the cytosol or nucleus is possible in vitro for DNA, RNA and proteins, but translation for clinical use has been limited. Therapeutic delivery of macromolecules into cells requires overcoming substantially higher barriers compared to the use of small molecule drugs or proteins in the extracellular space. Breakthroughs like DNA delivery for approved gene therapies and RNA delivery for silencing of genes (patisiran, ONPATTRO
1000 Sacherschließung
lokal Genetic Therapy [MeSH]
gnd 1206347392 COVID-19
lokal Cancer Research
lokal Pharmaceutical Preparations [MeSH]
lokal COVID-19 [MeSH]
lokal Humans [MeSH]
lokal Review Article
lokal Molecular Medicine
lokal SARS-CoV-2 [MeSH]
lokal Antibodies
lokal Pharmacotherapy
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  1. https://orcid.org/0000-0002-9505-0427
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