The Challenging Pharmacokinetics of Mitotane: An Old Drug in Need of New Packaging

  1. Haider, Malik Salman
  2. Ahmad, Taufiq
  3. Groll, Jürgen
  4. Scherf-Clavel, Oliver
  5. Kroiss, Matthias
  6. Luxenhofer, Robert ORCID logo

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1000 Titel
  • The Challenging Pharmacokinetics of Mitotane: An Old Drug in Need of New Packaging
1000 Autor/in
  1. Haider, Malik Salman |
  2. Ahmad, Taufiq |
  3. Groll, Jürgen |
  4. Scherf-Clavel, Oliver |
  5. Kroiss, Matthias |
  6. Luxenhofer, Robert |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-21
1000 Erschienen in
1000 Quellenangabe
  • 46(5):575-593
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s13318-021-00700-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397669/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Adrenocortical carcinoma (ACC) is a malignant tumor originating from the adrenal gland cortex with a heterogeneous but overall dismal prognosis in advanced stages. For more than 50 years, mitotane has remained a cornerstone for the treatment of ACC as adjuvant and palliative therapy. It has a very poor aqueous solubility of 0.1 mg/l and high partition coefficient in octanol/water (log P) value of 6. The commercially available dosage form is 500 mg tablets (Lysodren
1000 Sacherschließung
lokal Pharmacy
lokal Pharmacology/Toxicology
lokal Antineoplastic Agents, Hormonal/chemistry [MeSH]
lokal Mitotane/administration
lokal Pharmaceutical Sciences/Technology
lokal Antineoplastic Agents, Hormonal/pharmacokinetics [MeSH]
lokal Humans [MeSH]
lokal Mitotane/chemistry [MeSH]
lokal Human Physiology
lokal Animals [MeSH]
lokal Medical Biochemistry
lokal Solubility [MeSH]
lokal Tissue Distribution [MeSH]
lokal Antineoplastic Agents, Hormonal/administration
lokal Adrenocortical Carcinoma/drug therapy [MeSH]
lokal Mitotane/pharmacokinetics [MeSH]
lokal Adrenal Cortex Neoplasms/drug therapy [MeSH]
lokal Biological Availability [MeSH]
lokal Leading Article
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/SGFpZGVyLCBNYWxpayBTYWxtYW4=|https://frl.publisso.de/adhoc/uri/QWhtYWQsIFRhdWZpcQ==|https://frl.publisso.de/adhoc/uri/R3JvbGwsIErDvHJnZW4=|https://frl.publisso.de/adhoc/uri/U2NoZXJmLUNsYXZlbCwgT2xpdmVy|https://frl.publisso.de/adhoc/uri/S3JvaXNzLCBNYXR0aGlhcw==|https://orcid.org/0000-0001-5567-7404
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1000 Erstellt am 2023-11-16T08:41:09.681+0100
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