Drug utilization analysis of osteoporosis medications in seven European electronic health databases

  1. Tan, Eng Hooi
  2. Robinson, Danielle E.
  3. Jödicke, Annika
  4. Mosseveld, Mees
  5. Bodkergaard, Katrine
  6. Reyes, Carlen
  7. Moayyeri, Alireza
  8. Voss, Annemarie
  9. Marconi, Ettore
  10. Lapi, Francesco
  11. Reinold, Jonas ORCID logo
  12. Verhamme, Katia
  13. Pedersen, Lars
  14. Braitmaier, Malte ORCID logo
  15. De Wilde, Marten
  16. Far Ruiz, Marc
  17. Aragón, Maria
  18. Bosco-Levy, Pauline
  19. Lassalle, Regis
  20. Prieto-Alhambra, Daniel ORCID logo
  21. Sanchez-Santos, Maria

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WeightNameValue
1000 Titel
  • Drug utilization analysis of osteoporosis medications in seven European electronic health databases
1000 Autor/in
  1. Tan, Eng Hooi |
  2. Robinson, Danielle E. |
  3. Jödicke, Annika |
  4. Mosseveld, Mees |
  5. Bodkergaard, Katrine |
  6. Reyes, Carlen |
  7. Moayyeri, Alireza |
  8. Voss, Annemarie |
  9. Marconi, Ettore |
  10. Lapi, Francesco |
  11. Reinold, Jonas |
  12. Verhamme, Katia |
  13. Pedersen, Lars |
  14. Braitmaier, Malte |
  15. De Wilde, Marten |
  16. Far Ruiz, Marc |
  17. Aragón, Maria |
  18. Bosco-Levy, Pauline |
  19. Lassalle, Regis |
  20. Prieto-Alhambra, Daniel |
  21. Sanchez-Santos, Maria |
1000 Erscheinungsjahr 2023
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-07-12
1000 Erschienen in
1000 Quellenangabe
  • 34(10):1771-1781
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00198-023-06837-0 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511353/ |
1000 Ergänzendes Material
  • https://link.springer.com/article/10.1007/s00198-023-06837-0#Sec11 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • SUMMARY: We studied the characteristics of patients prescribed osteoporosis medication and patterns of use in European databases. Patients were mostly female, older, had hypertension. There was suboptimal persistence particularly for oral medications. Our findings would be useful to healthcare providers to focus their resources on improving persistence to specific osteoporosis treatments. PURPOSE: To characterise the patients prescribed osteoporosis therapy and describe the drug utilization patterns. METHODS: We investigated the treatment patterns of bisphosphonates, denosumab, teriparatide, and selective estrogen receptor modulators (SERMs) in seven European databases in the United Kingdom, Italy, the Netherlands, Denmark, Spain, and Germany. In this cohort study, we included adults aged ≥ 18 years, with ≥ 1 year of registration in the respective databases, who were new users of the osteoporosis medications. The study period was between 01 January 2018 to 31 January 2022. RESULTS: Overall, patients were most commonly initiated on alendronate. Persistence decreased over time across all medications and databases, ranging from 52–73% at 6 months to 29–53% at 12 months for alendronate. For other oral bisphosphonates, the proportion of persistent users was 50–66% at 6 months and decreased to 30–44% at 12 months. For SERMs, the proportion of persistent users at 6 months was 40–73% and decreased to 25–59% at 12 months. For parenteral treatment groups, the proportions of persistence with denosumab were 50–85% (6 month), 30–63% (12 month) and with teriparatide 40–75% (6 month) decreasing to 21–54% (12 month). Switching occurred most frequently in the alendronate group (2.8–5.8%) and in the teriparatide group (7.1–14%). Switching typically occurred in the first 6 months and decreased over time. Patients in the alendronate group most often switched to other oral or intravenous bisphosphonates and denosumab. CONCLUSION: Our results show suboptimal persistence to medications that varied across different databases and treatment switching was relatively rare.
1000 Sacherschließung
lokal Persistence
lokal Anti-resorptive drug
lokal Anabolic drug
lokal Osteoporosis
lokal Switching
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/VGFuLCBFbmcgSG9vaQ==|https://frl.publisso.de/adhoc/uri/Um9iaW5zb24sIERhbmllbGxlIEUu|https://frl.publisso.de/adhoc/uri/SsO2ZGlja2UsIEFubmlrYQ==|https://frl.publisso.de/adhoc/uri/TW9zc2V2ZWxkLCBNZWVz|https://frl.publisso.de/adhoc/uri/Qm9ka2VyZ2FhcmQsIEthdHJpbmU=|https://frl.publisso.de/adhoc/uri/UmV5ZXMsIENhcmxlbg==|https://frl.publisso.de/adhoc/uri/TW9heXllcmksIEFsaXJlemE=|https://frl.publisso.de/adhoc/uri/Vm9zcywgQW5uZW1hcmll|https://frl.publisso.de/adhoc/uri/TWFyY29uaSwgRXR0b3Jl|https://frl.publisso.de/adhoc/uri/TGFwaSwgRnJhbmNlc2Nv|https://orcid.org/0000-0001-8266-2574|https://frl.publisso.de/adhoc/uri/VmVyaGFtbWUsIEthdGlh|https://frl.publisso.de/adhoc/uri/UGVkZXJzZW4sIExhcnM=|https://orcid.org/0000-0001-7534-4068|https://frl.publisso.de/adhoc/uri/RGUgV2lsZGUsIE1hcnRlbg==|https://frl.publisso.de/adhoc/uri/RmFyIFJ1aXosIE1hcmM=|https://frl.publisso.de/adhoc/uri/QXJhZ8OzbiwgTWFyaWE=|https://frl.publisso.de/adhoc/uri/Qm9zY28tTGV2eSwgUGF1bGluZQ==|https://frl.publisso.de/adhoc/uri/TGFzc2FsbGUsIFJlZ2lz|https://orcid.org/0000-0002-3950-6346|https://frl.publisso.de/adhoc/uri/U2FuY2hlei1TYW50b3MsIE1hcmlh
1000 Label
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  1. Union Chimique Belge |
  2. Amgen |
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  1. Drug utilization analysis of osteoporosis medications in seven European electronic health databases
    Drug utilization analysis of osteoporosis medications in seven European electronic health databases
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1000 Erstellt am 2023-11-16T10:31:19.304+0100
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