The role of microglia membrane potential in chemotaxis

  1. Laprell, Laura
  2. Schulze, Christian
  3. Brehme, Marie-Luise
  4. Oertner, Thomas ORCID logo

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1000 Titel
  • The role of microglia membrane potential in chemotaxis
1000 Autor/in
  1. Laprell, Laura |
  2. Schulze, Christian |
  3. Brehme, Marie-Luise |
  4. Oertner, Thomas |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-01-10
1000 Erschienen in
1000 Quellenangabe
  • 18(1):21
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12974-020-02048-0 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798195/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Microglia react to danger signals by rapid and targeted extension of cellular processes towards the source of the signal. This positive chemotactic response is accompanied by a hyperpolarization of the microglia membrane. Here, we show that optogenetic depolarization of microglia has little effect on baseline motility, but significantly slows down the chemotactic response. Reducing the extracellular Ca
1000 Sacherschließung
lokal Two-photon microscopy
lokal Calcium Signaling/physiology [MeSH]
lokal Microscopy, Fluorescence, Multiphoton/methods [MeSH]
lokal Laser damage
lokal Chemotaxis/physiology [MeSH]
lokal Mice, Transgenic [MeSH]
lokal Male [MeSH]
lokal Chemotaxis
lokal Hippocampus/physiology [MeSH]
lokal Microglia/chemistry [MeSH]
lokal Calcium signaling
lokal Optogenetics
lokal Short Report
lokal Female [MeSH]
lokal Optogenetics/methods [MeSH]
lokal Hippocampus
lokal Microglia/physiology [MeSH]
lokal Microglia
lokal Membrane Potentials/physiology [MeSH]
lokal Animals [MeSH]
lokal Mice [MeSH]
lokal Channelrhodopsin
lokal Hippocampus/cytology [MeSH]
lokal Organ Culture Techniques [MeSH]
lokal Hippocampus/chemistry [MeSH]
lokal Sterile inflammation
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TGFwcmVsbCwgTGF1cmE=|https://frl.publisso.de/adhoc/uri/U2NodWx6ZSwgQ2hyaXN0aWFu|https://frl.publisso.de/adhoc/uri/QnJlaG1lLCBNYXJpZS1MdWlzZQ==|https://orcid.org/0000-0002-2312-7528
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  1. The role of microglia membrane potential in chemotaxis
    The role of microglia membrane potential in chemotaxis
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1000 Erstellt am 2023-11-16T16:33:41.584+0100
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1000 Zuletzt bearbeitet 2023-12-01T03:08:49.866+0100
1000 Objekt bearb. Fri Dec 01 03:08:49 CET 2023
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