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1000 Titel
  • Proinflammatory T cell polarization is already present in patients with early knee osteoarthritis
1000 Autor/in
  1. Rosshirt, Nils |
  2. Trauth, Richard |
  3. Platzer, Hadrian |
  4. Tripel, Elena |
  5. Nees, Timo A. |
  6. Lorenz, Hanns-Martin |
  7. Tretter, Theresa |
  8. Moradi, Babak |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-01-22
1000 Erschienen in
1000 Quellenangabe
  • 23(1):37
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s13075-020-02410-w |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821658/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Investigating the pathophysiological mechanisms of early osteoarthritis (OA) is of utmost interest since this stage holds the strongest promise for therapeutic interventions. The aims of this study were to analyze if synovial inflammation is already present in early OA and to characterize the involved cell populations, by investigating synovial fluid (SF) and synovial membrane (SM) of early OA patients for the presence and polarization status of CD4 T cells.!##!Methods!#!A quantitative analysis of CD4!##!Results!#!SF and SM showed a distinct infiltration of CD4!##!Conclusions!#!Early OA joints show already significant inflammation through CD4
1000 Sacherschließung
lokal Chemokine receptor
lokal Synovial membrane
lokal Humans [MeSH]
lokal Osteoarthritis, Knee [MeSH]
lokal Inflammatory T cells
lokal Early OA
lokal Lymphocyte Activation [MeSH]
lokal T cell polarization
lokal Synovial Fluid [MeSH]
lokal Cytokines
lokal Synovial Membrane [MeSH]
lokal T helper cells
lokal Synovial fluid
lokal Research Article
lokal Th1 Cells [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-8672-1938|https://frl.publisso.de/adhoc/uri/VHJhdXRoLCBSaWNoYXJk|https://frl.publisso.de/adhoc/uri/UGxhdHplciwgSGFkcmlhbg==|https://frl.publisso.de/adhoc/uri/VHJpcGVsLCBFbGVuYQ==|https://frl.publisso.de/adhoc/uri/TmVlcywgVGltbyBBLg==|https://frl.publisso.de/adhoc/uri/TG9yZW56LCBIYW5ucy1NYXJ0aW4=|https://frl.publisso.de/adhoc/uri/VHJldHRlciwgVGhlcmVzYQ==|https://frl.publisso.de/adhoc/uri/TW9yYWRpLCBCYWJhaw==
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1000 Erstellt am 2023-11-16T17:37:13.081+0100
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1000 Zuletzt bearbeitet Fri Dec 01 03:24:35 CET 2023
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