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1000 Titel
  • Opioid users show worse baseline knee osteoarthritis and faster progression of degenerative changes: a retrospective case-control study based on data from the Osteoarthritis Initiative (OAI)
1000 Autor/in
  1. Bodden, Jannis |
  2. Joseph, Gabby B. |
  3. Schirò, Silvia |
  4. Lynch, John A. |
  5. Lane, Nancy E. |
  6. McCulloch, Charles E. |
  7. Nevitt, Michael C. |
  8. Link, Thomas M. |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-05-22
1000 Erschienen in
1000 Quellenangabe
  • 23(1):146
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s13075-021-02524-9 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140460/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Opioids are frequently prescribed for pain control in knee osteoarthritis patients, despite recommendations by current guidelines. Previous studies have investigated the chondrotoxicity of different opioid subtypes. However, the impact opioids may have on progression of osteoarthritis in vivo remains unknown. The aim of this study was thus to describe the associations between opioid use and knee structural changes and clinical outcomes, over 4 years.!##!Methods!#!Participants with baseline opioid use (n=181) and who continued use for ≥1 year between baseline and 4-year follow-up (n=79) were included from the Osteoarthritis Initiative cohort and frequency matched with non-users (controls) (1:2). Whole-Organ Magnetic Resonance Imaging Scores (WORMS) were obtained, including a total summation score (WORMS total, range 0-96) and subscores for cartilage (0-36), menisci (0-24), and bone marrow abnormalities and subchondral cyst-like lesions (0-18, respectively). Knee Injury Osteoarthritis Outcomes score (KOOS) symptoms, quality of life (QOL), and pain were also obtained at baseline and follow-up (range 0-100; lower scores indicate worse outcomes). Using linear regression models, associations between baseline and longitudinal findings were investigated. As pain may modify observations, a sensitivity analysis was performed for longitudinal findings. All analyses were adjusted for sex, BMI, age, race, and Kellgren-Lawrence grade.!##!Results!#!Opioid users had greater structural degeneration at baseline (WORMS total: Coef. [95% CI], P; 7.1 [5.5, 8.8], <0.001) and a greater increase over 4 years (4.7 [2.9, 6.5], <0.001), compared to controls. Cartilage and meniscus scores increased greater in opioid users, compared to controls (P≤0.001), and findings withstood the adjustment for baseline pain (P≤0.002). All baseline KOOS scores were lower in opioid users compared to controls (P<0.001). QOL loss was greater, when adjusted for baseline KOOS pain (QOL -6.9 [-11.6, -2.1], 0.005).!##!Conclusions!#!Opioid users had worse baseline knee structural degeneration and faster progression. Opioid use was also associated with worse symptoms, pain, and QOL. Furthermore, QOL loss was greater in opioid users compared to controls, when adjusted for baseline KOOS pain, indicating that opioids may not be suited to prevent subjective disease progression in KOA patients.
1000 Sacherschließung
lokal Disease Progression [MeSH]
lokal Humans [MeSH]
lokal Retrospective Studies [MeSH]
lokal Opioids
lokal Osteoarthritis, Knee [MeSH]
lokal Knee Joint [MeSH]
lokal Analgesics, Opioid [MeSH]
lokal Magnetic Resonance Imaging [MeSH]
lokal Cartilage, Articular [MeSH]
lokal Knee
lokal Quality of Life [MeSH]
lokal Pain
lokal Osteoarthritis
lokal Magnetic resonance imaging
lokal Case-Control Studies [MeSH]
lokal Research Article
lokal Osteoarthritis Initiative
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-5997-203X|https://frl.publisso.de/adhoc/uri/Sm9zZXBoLCBHYWJieSBCLg==|https://frl.publisso.de/adhoc/uri/U2NoaXLDsiwgU2lsdmlh|https://frl.publisso.de/adhoc/uri/THluY2gsIEpvaG4gQS4=|https://frl.publisso.de/adhoc/uri/TGFuZSwgTmFuY3kgRS4=|https://frl.publisso.de/adhoc/uri/TWNDdWxsb2NoLCBDaGFybGVzIEUu|https://frl.publisso.de/adhoc/uri/TmV2aXR0LCBNaWNoYWVsIEMu|https://frl.publisso.de/adhoc/uri/TGluaywgVGhvbWFzIE0u
1000 Hinweis
  • DeepGreen-ID: d5407ed2d4ed41789a67f2281fe763e5 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 @id frl:6465966.rdf
1000 Erstellt am 2023-11-16T17:45:09.645+0100
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1000 Zuletzt bearbeitet 2023-12-01T03:26:31.217+0100
1000 Objekt bearb. Fri Dec 01 03:26:31 CET 2023
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