Impact of phosphodiesterases PDE3 and PDE4 on 5-hydroxytryptamine receptor4-mediated increase of cAMP in human atrial fibrillation

  1. Dolce, Bernardo
  2. Christ, Torsten
  3. Grammatika Pavlidou, Nefeli
  4. Yildirim, Yalin
  5. Reichenspurner, Hermann
  6. Eschenhagen, Thomas
  7. Nikolaev, Viacheslav O.
  8. Kaumann, Alberto J
  9. E Molina, Cristina ORCID logo

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WeightNameValue
1000 Titel
  • Impact of phosphodiesterases PDE3 and PDE4 on 5-hydroxytryptamine receptor4-mediated increase of cAMP in human atrial fibrillation
1000 Autor/in
  1. Dolce, Bernardo |
  2. Christ, Torsten |
  3. Grammatika Pavlidou, Nefeli |
  4. Yildirim, Yalin |
  5. Reichenspurner, Hermann |
  6. Eschenhagen, Thomas |
  7. Nikolaev, Viacheslav O. |
  8. Kaumann, Alberto J |
  9. E Molina, Cristina |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-09-19
1000 Erschienen in
1000 Quellenangabe
  • 394(2):291-298
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00210-020-01968-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835186/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Atrial fibrillation (AF)-associated remodeling includes contractile dysfunction whose reasons are only partially resolved. Serotonin (5-HT) increases contractile force and causes arrhythmias in atrial trabeculae from patients in sinus rhythm (SR). In persistent atrial fibrillation (peAF), the force responses to 5-HT are blunted and arrhythmic effects are abolished. Since force but not arrhythmic responses to 5-HT in peAF could be restored by PDE3 + PDE4 inhibition, we sought to perform real-time measurements of cAMP to understand whether peAF alters PDE3 + PDE4-mediated compartmentation of 5-HT
1000 Sacherschließung
lokal Female [MeSH]
lokal Phosphodiesterases
lokal Aged [MeSH]
lokal Humans [MeSH]
lokal Atrial Fibrillation/metabolism [MeSH]
lokal Middle Aged [MeSH]
lokal Atrial fibrillation
lokal Human cardiomyocytes
lokal Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism [MeSH]
lokal Original Article
lokal Cyclic AMP/metabolism [MeSH]
lokal Male [MeSH]
lokal Myocytes, Cardiac/metabolism [MeSH]
lokal Cyclic Nucleotide Phosphodiesterases, Type 3/metabolism [MeSH]
lokal Receptors, Serotonin, 5-HT4/metabolism [MeSH]
lokal 5-HT
lokal cAMP
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/RG9sY2UsIEJlcm5hcmRv|https://frl.publisso.de/adhoc/uri/Q2hyaXN0LCBUb3JzdGVu|https://frl.publisso.de/adhoc/uri/R3JhbW1hdGlrYSBQYXZsaWRvdSwgTmVmZWxp|https://frl.publisso.de/adhoc/uri/WWlsZGlyaW0sIFlhbGlu|https://frl.publisso.de/adhoc/uri/UmVpY2hlbnNwdXJuZXIsIEhlcm1hbm4=|https://frl.publisso.de/adhoc/uri/RXNjaGVuaGFnZW4sIFRob21hcw==|https://frl.publisso.de/adhoc/uri/Tmlrb2xhZXYsIFZpYWNoZXNsYXYgTy4=|https://frl.publisso.de/adhoc/uri/S2F1bWFubiwgQWxiZXJ0byBK|https://orcid.org/0000-0003-3094-1568
1000 Hinweis
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1000 Erstellt am 2023-11-16T22:47:29.905+0100
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1000 Zuletzt bearbeitet 2023-12-01T04:10:07.473+0100
1000 Objekt bearb. Fri Dec 01 04:10:07 CET 2023
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