FHL-1 is not involved in pressure overload-induced maladaptive right ventricular remodeling and dysfunction

  1. Veith, Christine
  2. Neghabian, Dariusch
  3. Luitel, Himal
  4. Wilhelm, Jochen
  5. Egemnazarov, Bakytbek
  6. Muntanjohl, Caja
  7. Fischer, Jan-Hendrik
  8. Dahal, Bhola Kumar
  9. Schermuly, Ralph Theo
  10. Ghofrani, Hossein Ardeschir
  11. Grimminger, Friedrich
  12. Fink, Ludger
  13. Kwapiszewska, Grazyna
  14. Weissmann, Norbert
  15. Sydykov, Akylbek

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WeightNameValue
1000 Titel
  • FHL-1 is not involved in pressure overload-induced maladaptive right ventricular remodeling and dysfunction
1000 Autor/in
  1. Veith, Christine |
  2. Neghabian, Dariusch |
  3. Luitel, Himal |
  4. Wilhelm, Jochen |
  5. Egemnazarov, Bakytbek |
  6. Muntanjohl, Caja |
  7. Fischer, Jan-Hendrik |
  8. Dahal, Bhola Kumar |
  9. Schermuly, Ralph Theo |
  10. Ghofrani, Hossein Ardeschir |
  11. Grimminger, Friedrich |
  12. Fink, Ludger |
  13. Kwapiszewska, Grazyna |
  14. Weissmann, Norbert |
  15. Sydykov, Akylbek |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-01-24
1000 Erschienen in
1000 Quellenangabe
  • 115(2):17
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00395-019-0767-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981327/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Aims!#!The cytoskeletal signaling protein four and-a-half LIM domains 1 (FHL-1) has recently been identified as a novel key player in pulmonary hypertension as well as in left heart diseases. In this regard, FHL-1 has been implicated in dysregulated hypertrophic signaling in pulmonary arterial smooth muscle cells leading to pulmonary hypertension. In mice, FHL-1-deficiency (FHL-1!##!Methods and results!#!We investigated FHL-1 expression in C57Bl/6 mice subjected to chronic biomechanical stress and found it to be enhanced in the right ventricle (RV). Next, we subjected FHL-1!##!Conclusion!#!FHL-1 pathway is not involved in the control of adverse remodeling in the pressure overloaded RV.
1000 Sacherschließung
lokal Ventricular Dysfunction, Right/physiopathology [MeSH]
lokal Mice, Inbred C57BL [MeSH]
lokal Heart Ventricles/physiopathology [MeSH]
lokal Original Contribution
lokal LIM Domain Proteins/deficiency [MeSH]
lokal Ventricular Dysfunction, Right/pathology [MeSH]
lokal Ventricular Dysfunction, Right/genetics [MeSH]
lokal Hypertrophy, Right Ventricular/physiopathology [MeSH]
lokal Male [MeSH]
lokal Natriuretic Peptides/metabolism [MeSH]
lokal Four and-a-half LIM domain 1 protein
lokal Calcium-Binding Proteins/metabolism [MeSH]
lokal Ryanodine Receptor Calcium Release Channel/metabolism [MeSH]
lokal Muscle Proteins/metabolism [MeSH]
lokal Disease Models, Animal [MeSH]
lokal LIM Domain Proteins/genetics [MeSH]
lokal Muscle Proteins/genetics [MeSH]
lokal Cytoskeletal proteins
lokal Intracellular Signaling Peptides and Proteins/metabolism [MeSH]
lokal Fibrosis [MeSH]
lokal Hypertrophy, Right Ventricular/metabolism [MeSH]
lokal Ventricular Function, Right [MeSH]
lokal Intracellular Signaling Peptides and Proteins/deficiency [MeSH]
lokal Animals [MeSH]
lokal Mice, Knockout [MeSH]
lokal Ventricular Dysfunction, Right/metabolism [MeSH]
lokal Intracellular Signaling Peptides and Proteins/genetics [MeSH]
lokal Right ventricular hypertrophy
lokal Muscle Proteins/deficiency [MeSH]
lokal Hypertrophy, Right Ventricular/pathology [MeSH]
lokal Pulmonary arterial banding
lokal LIM Domain Proteins/metabolism [MeSH]
lokal Heart Ventricles/pathology [MeSH]
lokal Signal Transduction [MeSH]
lokal Hypertrophy, Right Ventricular/genetics [MeSH]
lokal Heart Ventricles/metabolism [MeSH]
lokal Ventricular Remodeling [MeSH]
lokal Pressure overload
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/VmVpdGgsIENocmlzdGluZQ==|https://frl.publisso.de/adhoc/uri/TmVnaGFiaWFuLCBEYXJpdXNjaA==|https://frl.publisso.de/adhoc/uri/THVpdGVsLCBIaW1hbA==|https://frl.publisso.de/adhoc/uri/V2lsaGVsbSwgSm9jaGVu|https://frl.publisso.de/adhoc/uri/RWdlbW5hemFyb3YsIEJha3l0YmVr|https://frl.publisso.de/adhoc/uri/TXVudGFuam9obCwgQ2FqYQ==|https://frl.publisso.de/adhoc/uri/RmlzY2hlciwgSmFuLUhlbmRyaWs=|https://frl.publisso.de/adhoc/uri/RGFoYWwsIEJob2xhIEt1bWFy|https://frl.publisso.de/adhoc/uri/U2NoZXJtdWx5LCBSYWxwaCBUaGVv|https://frl.publisso.de/adhoc/uri/R2hvZnJhbmksIEhvc3NlaW4gQXJkZXNjaGly|https://frl.publisso.de/adhoc/uri/R3JpbW1pbmdlciwgRnJpZWRyaWNo|https://frl.publisso.de/adhoc/uri/RmluaywgTHVkZ2Vy|https://frl.publisso.de/adhoc/uri/S3dhcGlzemV3c2thLCBHcmF6eW5h|https://frl.publisso.de/adhoc/uri/V2Vpc3NtYW5uLCBOb3JiZXJ0|https://frl.publisso.de/adhoc/uri/U3lkeWtvdiwgQWt5bGJlaw==
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1000 Erstellt am 2023-11-16T23:01:26.753+0100
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