Neuraminidase-1 promotes heart failure after ischemia/reperfusion injury by affecting cardiomyocytes and invading monocytes/macrophages

  1. Heimerl, Maren
  2. Sieve, Irina
  3. Ricke-Hoch, Melanie
  4. Erschow, Sergej
  5. Battmer, Karin
  6. Scherr, Michaela
  7. Hilfiker-Kleiner, Denise

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WeightNameValue
1000 Titel
  • Neuraminidase-1 promotes heart failure after ischemia/reperfusion injury by affecting cardiomyocytes and invading monocytes/macrophages
1000 Autor/in
  1. Heimerl, Maren |
  2. Sieve, Irina |
  3. Ricke-Hoch, Melanie |
  4. Erschow, Sergej |
  5. Battmer, Karin |
  6. Scherr, Michaela |
  7. Hilfiker-Kleiner, Denise |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-09-25
1000 Erschienen in
1000 Quellenangabe
  • 115(6):62
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00395-020-00821-z |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519006/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Neuraminidase (NEU)1 forms a multienzyme complex with beta-galactosidase (β-GAL) and protective-protein/cathepsin (PPC) A, which cleaves sialic-acids from cell surface glycoconjugates. We investigated the role of NEU1 in the myocardium after ischemia/reperfusion (I/R). Three days after inducing I/R, left ventricles (LV) of male mice (3 months-old) displayed upregulated neuraminidase activity and increased NEU1, β-GAL and PPCA expression. Mice hypomorphic for neu1 (hNEU1) had less neuraminidase activity, fewer pro-inflammatory (Lin
1000 Sacherschließung
lokal Heart Failure/immunology [MeSH]
lokal Neuraminidase/genetics [MeSH]
lokal Ventricular Function, Left [MeSH]
lokal Heart Failure/enzymology [MeSH]
lokal Mice, Inbred C57BL [MeSH]
lokal Original Contribution
lokal Myocardial Infarction/immunology [MeSH]
lokal Myocardial Infarction/pathology [MeSH]
lokal Gap Junctions/pathology [MeSH]
lokal Mice, Transgenic [MeSH]
lokal Macrophages/immunology [MeSH]
lokal Neuraminidase 1
lokal Male [MeSH]
lokal Myocardial Infarction/complications [MeSH]
lokal Macrophages/enzymology [MeSH]
lokal Ischemia/reperfusion
lokal Myocardial Infarction/enzymology [MeSH]
lokal Myocardial Reperfusion Injury/immunology [MeSH]
lokal Heart Failure/etiology [MeSH]
lokal Myocardial Reperfusion Injury/complications [MeSH]
lokal Disease Models, Animal [MeSH]
lokal Ventricular Dysfunction, Left/etiology [MeSH]
lokal Female [MeSH]
lokal Myocardial Reperfusion Injury/pathology [MeSH]
lokal Monocytes
lokal Myocytes, Cardiac/enzymology [MeSH]
lokal Heart Failure/physiopathology [MeSH]
lokal Inflammation
lokal Monocytes/immunology [MeSH]
lokal Neuraminidase/deficiency [MeSH]
lokal Cathepsin A/metabolism [MeSH]
lokal Animals [MeSH]
lokal Myocytes, Cardiac/pathology [MeSH]
lokal Hypertrophy, Left Ventricular/enzymology [MeSH]
lokal Gap Junctions/enzymology [MeSH]
lokal Ventricular Dysfunction, Left/immunology [MeSH]
lokal Myocardial Reperfusion Injury/enzymology [MeSH]
lokal Ventricular Dysfunction, Left/enzymology [MeSH]
lokal Ventricular Dysfunction, Left/physiopathology [MeSH]
lokal Mice, 129 Strain [MeSH]
lokal Hypertrophy, Left Ventricular/etiology [MeSH]
lokal Hypertrophy, Left Ventricular/physiopathology [MeSH]
lokal Sialidase 1
lokal Ventricular Remodeling [MeSH]
lokal beta-Galactosidase/metabolism [MeSH]
lokal Monocytes/enzymology [MeSH]
lokal Connexin 43/metabolism [MeSH]
lokal Hypertrophy, Left Ventricular/immunology [MeSH]
1000 Liste der Beteiligten
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1000 Erstellt am 2023-11-16T23:02:39.885+0100
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