Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia

  1. Hagemann, Nina
  2. Mohamud Yusuf, Ayan
  3. Martiny, Carlotta
  4. Zhang, Xiaoni
  5. Kleinschnitz, Christoph
  6. Gunzer, Matthias
  7. Kolesnick, Richard
  8. Gulbins, Erich
  9. Hermann, Dirk M.

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1000 Titel
  • Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia
1000 Autor/in
  1. Hagemann, Nina |
  2. Mohamud Yusuf, Ayan |
  3. Martiny, Carlotta |
  4. Zhang, Xiaoni |
  5. Kleinschnitz, Christoph |
  6. Gunzer, Matthias |
  7. Kolesnick, Richard |
  8. Gulbins, Erich |
  9. Hermann, Dirk M. |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-10-14
1000 Erschienen in
1000 Quellenangabe
  • 115(6):64
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00395-020-00823-x |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560939/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • By cleaving sphingomyelin into ceramide, which is an essential component of plasma membrane microdomains, acid sphingomyelinase (Asm) pivotally controls cell signaling. To define how the activation of the Asm/ceramide pathway, which occurs within seconds to minutes upon stress stimuli, influences brain ischemia/reperfusion (I/R) injury, we exposed male and female wildtype mice carrying both alleles of Asm's gene sphingomyelinase phosphodiesterase-1 (Smpd1
1000 Sacherschließung
lokal Reperfusion Injury/genetics [MeSH]
lokal Ceramide-rich membrane microdomain
lokal Heterozygote [MeSH]
lokal Sphingomyelin Phosphodiesterase/deficiency [MeSH]
lokal Mice, Inbred C57BL [MeSH]
lokal Original Contribution
lokal Reperfusion Injury/enzymology [MeSH]
lokal Reperfusion Injury/prevention
lokal Neutrophils/enzymology [MeSH]
lokal Microvessels/pathology [MeSH]
lokal Intercellular Adhesion Molecule-1/metabolism [MeSH]
lokal Male [MeSH]
lokal Sphingolipid
lokal Infarction, Middle Cerebral Artery/genetics [MeSH]
lokal Reperfusion Injury/pathology [MeSH]
lokal Disease Models, Animal [MeSH]
lokal Focal cerebral ischemia
lokal Homozygote [MeSH]
lokal Microvessels/enzymology [MeSH]
lokal Female [MeSH]
lokal Intercellular adhesion molecule-1
lokal Infarction, Middle Cerebral Artery/enzymology [MeSH]
lokal Inflammation
lokal Animals [MeSH]
lokal Time Factors [MeSH]
lokal Mice, Knockout [MeSH]
lokal Sphingomyelin Phosphodiesterase/genetics [MeSH]
lokal Infarction, Middle Cerebral Artery/pathology [MeSH]
lokal Leukocyte
lokal Neutrophil Infiltration [MeSH]
lokal Brain/blood supply [MeSH]
lokal Lipid raft
lokal Middle cerebral artery occlusion
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/SGFnZW1hbm4sIE5pbmE=|https://frl.publisso.de/adhoc/uri/TW9oYW11ZCBZdXN1ZiwgQXlhbg==|https://frl.publisso.de/adhoc/uri/TWFydGlueSwgQ2FybG90dGE=|https://frl.publisso.de/adhoc/uri/WmhhbmcsIFhpYW9uaQ==|https://frl.publisso.de/adhoc/uri/S2xlaW5zY2huaXR6LCBDaHJpc3RvcGg=|https://frl.publisso.de/adhoc/uri/R3VuemVyLCBNYXR0aGlhcw==|https://frl.publisso.de/adhoc/uri/S29sZXNuaWNrLCBSaWNoYXJk|https://frl.publisso.de/adhoc/uri/R3VsYmlucywgRXJpY2g=|https://frl.publisso.de/adhoc/uri/SGVybWFubiwgRGlyayBNLg==
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1000 Erstellt am 2023-11-16T23:05:15.475+0100
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1000 Objekt bearb. Fri Dec 01 04:14:15 CET 2023
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