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1000 Titel
  • Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions
1000 Autor/in
  1. Britz, Hannah |
  2. Hanke, Nina |
  3. Taub, Mitchell E. |
  4. Wang, Ting |
  5. Prasad, Bhagwat |
  6. Fernandez, Éric |
  7. Stopfer, Peter |
  8. Nock, Valerie |
  9. Lehr, Thorsten |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-11-25
1000 Erschienen in
1000 Quellenangabe
  • 37(12):250
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s11095-020-02964-z |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688195/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!To provide whole-body physiologically based pharmacokinetic (PBPK) models of the potent clinical organic anion transporter (OAT) inhibitor probenecid and the clinical OAT victim drug furosemide for their application in transporter-based drug-drug interaction (DDI) modeling.!##!Methods!#!PBPK models of probenecid and furosemide were developed in PK-Sim®. Drug-dependent parameters and plasma concentration-time profiles following intravenous and oral probenecid and furosemide administration were gathered from literature and used for model development. For model evaluation, plasma concentration-time profiles, areas under the plasma concentration-time curve (AUC) and peak plasma concentrations (C!##!Results!#!The developed models accurately describe the reported plasma concentrations of 27 clinical probenecid studies and of 42 studies using furosemide. Furthermore, application of these models to predict the probenecid-furosemide and probenecid-rifampicin DDIs demonstrates their good performance, with 6/7 of the predicted DDI AUC ratios and 4/5 of the predicted DDI C!##!Conclusions!#!Whole-body PBPK models of probenecid and furosemide were built and evaluated, providing useful tools to support the investigation of transporter mediated DDIs.
1000 Sacherschließung
lokal probenecid
lokal Biotransformation [MeSH]
lokal drug-drug interaction (DDI)
lokal Organic Anion Transporters/antagonists
lokal Computer Simulation [MeSH]
lokal Models, Biological [MeSH]
lokal Furosemide/administration
lokal Administration, Oral [MeSH]
lokal Male [MeSH]
lokal Probenecid/blood [MeSH]
lokal Probenecid/pharmacokinetics [MeSH]
lokal Drug Interactions [MeSH]
lokal physiologically based pharmacokinetic modeling (PBPK)
lokal Rifampin/pharmacokinetics [MeSH]
lokal Probenecid/administration
lokal Female [MeSH]
lokal organic anion transporter (OAT)
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal furosemide
lokal Furosemide/pharmacokinetics [MeSH]
lokal Administration, Intravenous [MeSH]
lokal Research Paper
lokal Furosemide/blood [MeSH]
lokal Drug Elimination Routes [MeSH]
lokal Organic Anion Transporters/metabolism [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/QnJpdHosIEhhbm5haA==|https://frl.publisso.de/adhoc/uri/SGFua2UsIE5pbmE=|https://frl.publisso.de/adhoc/uri/VGF1YiwgTWl0Y2hlbGwgRS4=|https://frl.publisso.de/adhoc/uri/V2FuZywgVGluZw==|https://frl.publisso.de/adhoc/uri/UHJhc2FkLCBCaGFnd2F0|https://frl.publisso.de/adhoc/uri/RmVybmFuZGV6LCDDiXJpYw==|https://frl.publisso.de/adhoc/uri/U3RvcGZlciwgUGV0ZXI=|https://frl.publisso.de/adhoc/uri/Tm9jaywgVmFsZXJpZQ==|https://orcid.org/0000-0002-8372-1465
1000 Hinweis
  • DeepGreen-ID: ae26ab1ded3f42099d3cfa5334ce772c ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-11-16T23:34:39.145+0100
1000 Erstellt von 322
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1000 Zuletzt bearbeitet 2023-12-01T04:20:17.341+0100
1000 Objekt bearb. Fri Dec 01 04:20:17 CET 2023
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