Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD–TDP subtypes

  1. Neumann, Manuela ORCID logo
  2. Frick, Petra
  3. Paron, Francesca
  4. Kosten, Jonas
  5. Buratti, Emanuele
  6. Mackenzie, Ian R.

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WeightNameValue
1000 Titel
  • Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD–TDP subtypes
1000 Autor/in
  1. Neumann, Manuela |
  2. Frick, Petra |
  3. Paron, Francesca |
  4. Kosten, Jonas |
  5. Buratti, Emanuele |
  6. Mackenzie, Ian R. |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-08-10
1000 Erschienen in
1000 Quellenangabe
  • 140(5):645-658
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00401-020-02207-w |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547034/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Aggregation of hyperphosphorylated TDP-43 is the hallmark pathological feature of the most common molecular form of frontotemporal lobar degeneration (FTLD-TDP) and in the vast majority of cases with amyotrophic lateral sclerosis (ALS-TDP). However, most of the specific phosphorylation sites remain to be determined, and their relevance regarding pathogenicity and clinical and pathological phenotypic diversity in FTLD-TDP and ALS-TDP remains to be identified. Here, we generated a novel antibody raised against TDP-43 phosphorylated at serine 375 (pTDP-43
1000 Sacherschließung
lokal Conformation-specific
lokal Frontotemporal lobar degeneration
lokal Aged, 80 and over [MeSH]
lokal Phosphorylation [MeSH]
lokal Aged [MeSH]
lokal Amyotrophic Lateral Sclerosis/pathology [MeSH]
lokal Protein Aggregation, Pathological/metabolism [MeSH]
lokal Protein Conformation [MeSH]
lokal DNA-Binding Proteins/metabolism [MeSH]
lokal Male [MeSH]
lokal Phosphorylation-specific antibody
lokal DNA-Binding Proteins/chemistry [MeSH]
lokal TDP-43 strains
lokal Female [MeSH]
lokal Inclusion Bodies/metabolism [MeSH]
lokal Protein Aggregates [MeSH]
lokal Humans [MeSH]
lokal Middle Aged [MeSH]
lokal Amyotrophic Lateral Sclerosis/metabolism [MeSH]
lokal Inclusion Bodies/pathology [MeSH]
lokal Frontotemporal Dementia/metabolism [MeSH]
lokal Original Paper
lokal ALS
lokal Inclusion Bodies/chemistry [MeSH]
lokal Frontotemporal dementia
lokal TDP-43
lokal Frontotemporal Dementia/pathology [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-6232-4057|https://frl.publisso.de/adhoc/uri/RnJpY2ssIFBldHJh|https://frl.publisso.de/adhoc/uri/UGFyb24sIEZyYW5jZXNjYQ==|https://frl.publisso.de/adhoc/uri/S29zdGVuLCBKb25hcw==|https://frl.publisso.de/adhoc/uri/QnVyYXR0aSwgRW1hbnVlbGU=|https://frl.publisso.de/adhoc/uri/TWFja2VuemllLCBJYW4gUi4=
1000 Hinweis
  • DeepGreen-ID: 3b967873a89a423db88ad8aaa05f621e ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-11-17T02:39:10.967+0100
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1000 Zuletzt bearbeitet 2023-12-01T04:47:23.063+0100
1000 Objekt bearb. Fri Dec 01 04:47:23 CET 2023
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1000 Oai Id
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