Prediction of exposure-driven myelotoxicity of continuous infusion 5-fluorouracil by a semi-physiological pharmacokinetic–pharmacodynamic model in gastrointestinal cancer patients

  1. Arshad, Usman ORCID logo
  2. Ploylearmsaeng, Su-arpa
  3. Karlsson, Mats O.
  4. Doroshyenko, Oxana
  5. Langer, Dorothee
  6. Schömig, Edgar
  7. Kunze, Sabine
  8. Güner, Semih A.
  9. Skripnichenko, Roman
  10. Ullah, Sami
  11. Jaehde, Ulrich
  12. Fuhr, Uwe
  13. Jetter, Alexander
  14. Taubert, Max

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1000 Titel
  • Prediction of exposure-driven myelotoxicity of continuous infusion 5-fluorouracil by a semi-physiological pharmacokinetic–pharmacodynamic model in gastrointestinal cancer patients
1000 Autor/in
  1. Arshad, Usman |
  2. Ploylearmsaeng, Su-arpa |
  3. Karlsson, Mats O. |
  4. Doroshyenko, Oxana |
  5. Langer, Dorothee |
  6. Schömig, Edgar |
  7. Kunze, Sabine |
  8. Güner, Semih A. |
  9. Skripnichenko, Roman |
  10. Ullah, Sami |
  11. Jaehde, Ulrich |
  12. Fuhr, Uwe |
  13. Jetter, Alexander |
  14. Taubert, Max |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-03-09
1000 Erschienen in
1000 Quellenangabe
  • 85(4):711-722
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00280-019-04028-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125253/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!To describe 5-fluorouracil (5FU) pharmacokinetics, myelotoxicity and respective covariates using a simultaneous nonlinear mixed effect modelling approach.!##!Methods!#!Thirty patients with gastrointestinal cancer received 5FU 650 or 1000 mg/m!##!Results!#!Total clearance of 5FU correlated with body surface area (BSA). Population estimate for total clearance was 249 L/h. Clearances of 5FU and 5FUH2 fractionally changed by 77%/m!##!Conclusions!#!BSA should be taken into account for predicting 5FU exposure. Myelosuppression was influenced by 5FU exposure and concomitant administration of cisplatin.
1000 Sacherschließung
lokal Aged [MeSH]
lokal Myeloid Cells/pathology [MeSH]
lokal 5-Fluorouracil
lokal Models, Biological [MeSH]
lokal Original Article
lokal Nonlinear Dynamics [MeSH]
lokal Male [MeSH]
lokal Pharmacogenetics
lokal Tissue Distribution [MeSH]
lokal Fluorouracil/pharmacology [MeSH]
lokal Antimetabolites, Antineoplastic/pharmacology [MeSH]
lokal Fluorouracil/administration
lokal Female [MeSH]
lokal Follow-Up Studies [MeSH]
lokal Adult [MeSH]
lokal Antimetabolites, Antineoplastic/adverse effects [MeSH]
lokal Humans [MeSH]
lokal Gastrointestinal Neoplasms/drug therapy [MeSH]
lokal Infusions, Intravenous [MeSH]
lokal Middle Aged [MeSH]
lokal Pharmacodynamics
lokal Myeloid Cells/drug effects [MeSH]
lokal Antimetabolites, Antineoplastic/administration
lokal Pharmacokinetics
lokal Prognosis [MeSH]
lokal Myelosuppression
lokal Gastrointestinal Neoplasms/pathology [MeSH]
lokal Fluorouracil/adverse effects [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-7003-5300|https://frl.publisso.de/adhoc/uri/UGxveWxlYXJtc2FlbmcsIFN1LWFycGE=|https://frl.publisso.de/adhoc/uri/S2FybHNzb24sIE1hdHMgTy4=|https://frl.publisso.de/adhoc/uri/RG9yb3NoeWVua28sIE94YW5h|https://frl.publisso.de/adhoc/uri/TGFuZ2VyLCBEb3JvdGhlZQ==|https://frl.publisso.de/adhoc/uri/U2Now7ZtaWcsIEVkZ2Fy|https://frl.publisso.de/adhoc/uri/S3VuemUsIFNhYmluZQ==|https://frl.publisso.de/adhoc/uri/R8O8bmVyLCBTZW1paCBBLg==|https://frl.publisso.de/adhoc/uri/U2tyaXBuaWNoZW5rbywgUm9tYW4=|https://frl.publisso.de/adhoc/uri/VWxsYWgsIFNhbWk=|https://frl.publisso.de/adhoc/uri/SmFlaGRlLCBVbHJpY2g=|https://frl.publisso.de/adhoc/uri/RnVociwgVXdl|https://frl.publisso.de/adhoc/uri/SmV0dGVyLCBBbGV4YW5kZXI=|https://frl.publisso.de/adhoc/uri/VGF1YmVydCwgTWF4
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1000 Erstellt am 2023-11-17T05:46:04.025+0100
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