Primary culture of the rat spinal dorsal horn: a tool to investigate the effects of inflammatory stimulation on the afferent somatosensory system

  1. Leisengang, Stephan
  2. Nürnberger, Franz
  3. Ott, Daniela
  4. Murgott, Jolanta
  5. Gerstberger, Rüdiger
  6. Rummel, Christoph
  7. Roth, Joachim

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1000 Titel
  • Primary culture of the rat spinal dorsal horn: a tool to investigate the effects of inflammatory stimulation on the afferent somatosensory system
1000 Autor/in
  1. Leisengang, Stephan |
  2. Nürnberger, Franz |
  3. Ott, Daniela |
  4. Murgott, Jolanta |
  5. Gerstberger, Rüdiger |
  6. Rummel, Christoph |
  7. Roth, Joachim |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-10-24
1000 Erschienen in
1000 Quellenangabe
  • 472(12):1769-1782
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00424-020-02478-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691309/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • One maladaptive consequence of inflammatory stimulation of the afferent somatosensory system is the manifestation of inflammatory pain. We established and characterized a neuroglial primary culture of the rat superficial dorsal horn (SDH) of the spinal cord to test responses of this structure to neurochemical, somatosensory, or inflammatory stimulation. Primary cultures of the rat SDH consist of neurons (43%), oligodendrocytes (35%), astrocytes (13%), and microglial cells (9%). Neurons of the SDH responded to cooling (7%), heating (18%), glutamate (80%), substance P (43%), prostaglandin E
1000 Sacherschließung
lokal Neuroscience
lokal Somatosensory system
lokal Lipopolysaccharides/pharmacology [MeSH]
lokal Neuronal and glial responses
lokal Spinal Cord Dorsal Horn/cytology [MeSH]
lokal Interleukins/metabolism [MeSH]
lokal Male [MeSH]
lokal Tumor Necrosis Factor-alpha/metabolism [MeSH]
lokal Spinal Cord Dorsal Horn/drug effects [MeSH]
lokal Primary culture
lokal
lokal Substance P/pharmacology [MeSH]
lokal Primary Cell Culture/methods [MeSH]
lokal Tumor Necrosis Factor-alpha/genetics [MeSH]
lokal Female [MeSH]
lokal Inflammation
lokal Rats [MeSH]
lokal Glutamic Acid/pharmacology [MeSH]
lokal NF-kappa B/genetics [MeSH]
lokal Animals [MeSH]
lokal Rats, Wistar [MeSH]
lokal NF-kappa B/metabolism [MeSH]
lokal Interleukins/genetics [MeSH]
lokal Dinoprostone/pharmacology [MeSH]
lokal Posterior Horn Cells/drug effects [MeSH]
lokal Cells, Cultured [MeSH]
lokal Posterior Horn Cells/metabolism [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TGVpc2VuZ2FuZywgU3RlcGhhbg==|https://frl.publisso.de/adhoc/uri/TsO8cm5iZXJnZXIsIEZyYW56|https://frl.publisso.de/adhoc/uri/T3R0LCBEYW5pZWxh|https://frl.publisso.de/adhoc/uri/TXVyZ290dCwgSm9sYW50YQ==|https://frl.publisso.de/adhoc/uri/R2Vyc3RiZXJnZXIsIFLDvGRpZ2Vy|https://frl.publisso.de/adhoc/uri/UnVtbWVsLCBDaHJpc3RvcGg=|https://frl.publisso.de/adhoc/uri/Um90aCwgSm9hY2hpbQ==
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1000 Erstellt am 2023-11-17T09:06:13.138+0100
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1000 Zuletzt bearbeitet Fri Dec 01 05:59:02 CET 2023
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