Maximizing the diagnostic information from biopsies in chronic inflammatory bowel diseases: recommendations from the Erlangen International Consensus Conference on Inflammatory Bowel Diseases and presentation of the IBD-DCA score as a proposal for a new index for histologic activity assessment in ulcerative colitis and Crohn’s disease

  1. Lang-Schwarz, Corinna
  2. Agaimy, Abbas
  3. Atreya, Raja
  4. Becker, Christoph
  5. Danese, Silvio
  6. Fléjou, Jean-François
  7. Gaßler, Nikolaus
  8. Grabsch, Heike I.
  9. Hartmann, Arndt
  10. Kamarádová, Kateřina
  11. Kühl, Anja A.
  12. Lauwers, Gregory Y.
  13. Lugli, Alessandro
  14. Nagtegaal, Iris
  15. Neurath, Markus F.
  16. Oberhuber, Georg
  17. Peyrin-Biroulet, Laurent
  18. Rath, Timo
  19. Riddell, Robert
  20. Rubio, Carlos A.
  21. Sheahan, Kieran
  22. Tilg, Herbert
  23. Villanacci, Vincenzo
  24. Westerhoff, Maria
  25. Vieth, Michael

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1000 Titel
  • Maximizing the diagnostic information from biopsies in chronic inflammatory bowel diseases: recommendations from the Erlangen International Consensus Conference on Inflammatory Bowel Diseases and presentation of the IBD-DCA score as a proposal for a new index for histologic activity assessment in ulcerative colitis and Crohn’s disease
1000 Autor/in
  1. Lang-Schwarz, Corinna |
  2. Agaimy, Abbas |
  3. Atreya, Raja |
  4. Becker, Christoph |
  5. Danese, Silvio |
  6. Fléjou, Jean-François |
  7. Gaßler, Nikolaus |
  8. Grabsch, Heike I. |
  9. Hartmann, Arndt |
  10. Kamarádová, Kateřina |
  11. Kühl, Anja A. |
  12. Lauwers, Gregory Y. |
  13. Lugli, Alessandro |
  14. Nagtegaal, Iris |
  15. Neurath, Markus F. |
  16. Oberhuber, Georg |
  17. Peyrin-Biroulet, Laurent |
  18. Rath, Timo |
  19. Riddell, Robert |
  20. Rubio, Carlos A. |
  21. Sheahan, Kieran |
  22. Tilg, Herbert |
  23. Villanacci, Vincenzo |
  24. Westerhoff, Maria |
  25. Vieth, Michael |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-12-29
1000 Erschienen in
1000 Quellenangabe
  • 478(3):581-594
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00428-020-02982-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973393/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Developing biocompatible, synthetic oxygen carriers is a consistently challenging task that researchers have been pursuing for decades. Perfluorocarbons (PFC) are fascinating compounds with a huge capacity to dissolve gases, where the respiratory gases are of special interest for current investigations. Although largely chemically and biologically inert, pure PFCs are not suitable for injection into the vascular system. Extensive research created stable PFC nano-emulsions that avoid (i) fast clearance from the blood and (ii) long organ retention time, which leads to undesired transient side effects. PFC-based oxygen carriers (PFOCs) show a variety of application fields, which are worthwhile to investigate. To understand the difficulties that challenge researchers in creating formulations for clinical applications, this review provides the physical background of PFCs' properties and then illuminates the reasons for instabilities of PFC emulsions. By linking the unique properties of PFCs and PFOCs to physiology, it elaborates on the response, processing and dysregulation, which the body experiences through intravascular PFOCs. Thereby the reader will receive a scientific and easily comprehensible overview why PFOCs are precious tools for so many diverse application areas from cancer therapeutics to blood substitutes up to organ preservation and diving disease.
1000 Sacherschließung
lokal Colitis, Ulcerative/pathology [MeSH]
lokal Clinical Decision-Making [MeSH]
lokal Biopsy [MeSH]
lokal Humans [MeSH]
lokal Intestines/pathology [MeSH]
lokal Predictive Value of Tests [MeSH]
lokal Crohn Disease/therapy [MeSH]
lokal Crohn Disease/pathology [MeSH]
lokal Colitis, Ulcerative/therapy [MeSH]
lokal Decision Support Techniques [MeSH]
lokal Original Article
lokal Quality in Pathology
lokal Reproducibility of Results [MeSH]
lokal Prognosis [MeSH]
lokal Pathology
lokal Delphi Technique [MeSH]
lokal Consensus [MeSH]
1000 Liste der Beteiligten
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1000 Erstellt am 2023-11-17T09:16:14.024+0100
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1000 Zuletzt bearbeitet Fri Dec 01 06:01:43 CET 2023
1000 Objekt bearb. Fri Dec 01 06:01:43 CET 2023
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