Mechanical ventilation-induced alterations of intracellular surfactant pool and blood–gas barrier in healthy and pre-injured lungs

  1. Krischer, Jeanne-Marie
  2. Albert, Karolin
  3. Pfaffenroth, Alexander
  4. Lopez-Rodriguez, Elena
  5. Ruppert, Clemens
  6. Smith, Bradford J.
  7. Knudsen, Lars ORCID logo

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1000 Titel
  • Mechanical ventilation-induced alterations of intracellular surfactant pool and blood–gas barrier in healthy and pre-injured lungs
1000 Autor/in
  1. Krischer, Jeanne-Marie |
  2. Albert, Karolin |
  3. Pfaffenroth, Alexander |
  4. Lopez-Rodriguez, Elena |
  5. Ruppert, Clemens |
  6. Smith, Bradford J. |
  7. Knudsen, Lars |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-11-13
1000 Erschienen in
1000 Quellenangabe
  • 155(2):183-202
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00418-020-01938-x |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910377/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Mechanical ventilation triggers the manifestation of lung injury and pre-injured lungs are more susceptible. Ventilation-induced abnormalities of alveolar surfactant are involved in injury progression. The effects of mechanical ventilation on the surfactant system might be different in healthy compared to pre-injured lungs. In the present study, we investigated the effects of different positive end-expiratory pressure (PEEP) ventilations on the structure of the blood-gas barrier, the ultrastructure of alveolar epithelial type II (AE2) cells and the intracellular surfactant pool (= lamellar bodies, LB). Rats were randomized into bleomycin-pre-injured or healthy control groups. One day later, rats were either not ventilated, or ventilated with PEEP = 1 or 5 cmH
1000 Sacherschließung
lokal Rats, Inbred F344 [MeSH]
lokal Alveolar epithelial type II cells
lokal Rats [MeSH]
lokal Lung/metabolism [MeSH]
lokal Animals [MeSH]
lokal Surfactant
lokal Blood–gas barrier
lokal Pulmonary Surfactants/metabolism [MeSH]
lokal Bleomycin [MeSH]
lokal Lung Diseases/chemically induced [MeSH]
lokal Male [MeSH]
lokal Blood-Air Barrier/metabolism [MeSH]
lokal Original Paper
lokal Respiration, Artificial [MeSH]
lokal Mechanical ventilation
lokal Lamellar bodies
lokal Lung Diseases/metabolism [MeSH]
lokal Stereology
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/S3Jpc2NoZXIsIEplYW5uZS1NYXJpZQ==|https://frl.publisso.de/adhoc/uri/QWxiZXJ0LCBLYXJvbGlu|https://frl.publisso.de/adhoc/uri/UGZhZmZlbnJvdGgsIEFsZXhhbmRlcg==|https://frl.publisso.de/adhoc/uri/TG9wZXotUm9kcmlndWV6LCBFbGVuYQ==|https://frl.publisso.de/adhoc/uri/UnVwcGVydCwgQ2xlbWVucw==|https://frl.publisso.de/adhoc/uri/U21pdGgsIEJyYWRmb3JkIEou|https://orcid.org/0000-0002-7926-3879
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