Elevated MUC5AC expression is associated with mismatch repair deficiency and proximal tumor location but not with cancer progression in colon cancer

  1. Rico, Sebastian Dwertmann
  2. Höflmayer, Doris
  3. Büscheck, Franziska
  4. Dum, David
  5. Luebke, Andreas M.
  6. Kluth, Martina
  7. Hube-Magg, Claudia
  8. Hinsch, Andrea
  9. Möller-Koop, Christina
  10. Perez, Daniel
  11. Izbicki, Jakob R.
  12. Neipp, Michael
  13. Mofid, Hamid
  14. Lárusson, Hannes
  15. Daniels, Thies
  16. Isbert, Christoph
  17. Coerper, Stephan
  18. Ditterich, Daniel
  19. Rupprecht, Holger
  20. Goetz, Albert
  21. Fraune, Christoph
  22. Möller, Katharina
  23. Menz, Anne
  24. Bernreuther, Christian
  25. Clauditz, Till S.
  26. Sauter, Guido
  27. Uhlig, Ria
  28. Wilczak, Waldemar
  29. Simon, Ronald ORCID logo
  30. Steurer, Stefan
  31. Lebok, Patrick
  32. Burandt, Eike
  33. Krech, Till
  34. Marx, Andreas H.

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1000 Titel
  • Elevated MUC5AC expression is associated with mismatch repair deficiency and proximal tumor location but not with cancer progression in colon cancer
1000 Autor/in
  1. Rico, Sebastian Dwertmann |
  2. Höflmayer, Doris |
  3. Büscheck, Franziska |
  4. Dum, David |
  5. Luebke, Andreas M. |
  6. Kluth, Martina |
  7. Hube-Magg, Claudia |
  8. Hinsch, Andrea |
  9. Möller-Koop, Christina |
  10. Perez, Daniel |
  11. Izbicki, Jakob R. |
  12. Neipp, Michael |
  13. Mofid, Hamid |
  14. Lárusson, Hannes |
  15. Daniels, Thies |
  16. Isbert, Christoph |
  17. Coerper, Stephan |
  18. Ditterich, Daniel |
  19. Rupprecht, Holger |
  20. Goetz, Albert |
  21. Fraune, Christoph |
  22. Möller, Katharina |
  23. Menz, Anne |
  24. Bernreuther, Christian |
  25. Clauditz, Till S. |
  26. Sauter, Guido |
  27. Uhlig, Ria |
  28. Wilczak, Waldemar |
  29. Simon, Ronald |
  30. Steurer, Stefan |
  31. Lebok, Patrick |
  32. Burandt, Eike |
  33. Krech, Till |
  34. Marx, Andreas H. |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-12-29
1000 Erschienen in
1000 Quellenangabe
  • 54(2):156-165
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00795-020-00274-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139930/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Mucin 5AC (MUC5AC) is a secreted gel-forming mucin expressed by several epithelia. In the colon, MUC5AC is expressed in scattered normal epithelial cells but can be abundant in colorectal cancers. To clarify the relationship of MUC5AC expression with parameters of tumor aggressiveness and mismatch repair deficiency (dMMR) in colorectal cancer, a tissue microarray containing 1812 colorectal cancers was analyzed by immunohistochemistry. MUC5AC expression was found in 261 (15.7%) of 1,667 analyzable colorectal cancers. MUC5AC expression strongly depended on the tumor location and gradually decreased from proximal (27.4% of cecum cancers) to distal (10.6% of rectal cancers; p < 0.0001). MUC5AC expression was also strongly linked to dMMR. dMMR was found in 21.3% of 169 cancers with MUC5AC positivity but in only 4.6% of 1051 cancers without detectable MUC5AC expression (p < 0.0001). A multivariate analysis showed that dMMR status and tumor localization predicted MUC5AC expression independently (p < 0.0001 each). MUC5AC expression was unrelated to pT and pN status. This also applied to the subgroups of 1136 proficient MMR (pMMR) and of 84 dMMR cancers. The results of our study show a strong association of MUC5AC expression with proximal and dMMR colorectal cancers. However, MUC5AC expression is unrelated to colon cancer aggressiveness.
1000 Sacherschließung
lokal Gene Expression Regulation, Neoplastic [MeSH]
lokal Disease Progression [MeSH]
lokal Aged [MeSH]
lokal Humans [MeSH]
lokal MUC5AC
lokal Progression
lokal Tissue microarray
lokal Colorectal Neoplasms/metabolism [MeSH]
lokal Immunohistochemistry [MeSH]
lokal Mismatch repair deficiency
lokal Colorectal Neoplasms/pathology [MeSH]
lokal DNA Mismatch Repair [MeSH]
lokal Original Paper
lokal Colorectal Neoplasms/genetics [MeSH]
lokal Mucin 5AC/genetics [MeSH]
lokal Colon cancer
1000 Liste der Beteiligten
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1000 Erstellt am 2023-11-17T13:41:38.019+0100
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